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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 9

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TonyTonyChopper said:
bro plz quit weed fully. Yes you recovered but psychosis has a really high chance of coming back now that you have alot of dopamine in your brain. Just letting you know if you go psychotic again it will mean court ordered treatment for God knows how long and you might not recover this time. It's just not worth the psychosis risk .
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I have improved a lot but I am not 100% recovered yet
 
TonyTonyChopper said:
bro plz quit weed fully. Yes you recovered but psychosis has a really high chance of coming back now that you have alot of dopamine in your brain. Just letting you know if you go psychotic again it will mean court ordered treatment for God knows how long and you might not recover this time. It's just not worth the psychosis risk .
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Too afraid of being paranoid I haven't started drinking again brother it's shit
 
it's true that today's shit and weed have nothing to do with the 90s/2000s, it's deadly dangerous, all the people in psychiatry that I saw shocked me
 
okthen said:
It's scary stuff ain't it? I lost the ability to talk after the 2nd shot so couldn't complain, which led to me getting a few more before being able to voice my concerns
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Yeah same. That’s what scared me the most. It’s unexplainable losing the ability to talk. Trapped in your head. It’s horrible.
When I did start talking I talk like a retard struggling to get the words out.
okthen said:
Yeah sleep never felt normal since for me. Hard to explain. Instead of slowly falling asleep it's more of a lying there till I black out type of feeling
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Yeah that’s what it is. You lose the progression into sleep. And even now I find I’m always awake even when sleeping I don’t know how to describe.
 
maryjaneforever said:
Yeah same. That’s what scared me the most. It’s unexplainable losing the ability to talk. Trapped in your head. It’s horrible.
When I did start talking I talk like a retard struggling to get the words out.

Yeah that’s what it is. You lose the progression into sleep. And even now I find I’m always awake even when sleeping I don’t know how to describe.
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I had become the same I had no discussions there I found my discussions I am much more sociable
 
fenec said:
it's true that today's shit and weed have nothing to do with the 90s/2000s, it's deadly dangerous, all the people in psychiatry that I saw shocked me
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Apparently he cuts cannabis with medication, the brothers
 
maryjaneforever said:
But you had haldol, not invega?
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I had four aldol injections for 4 months and apparently haldol is even worse than invega beginning withdrawal joint pain tremor I stare at the wall all day for 7 8 months and I felt better and better it it was torture I thought about committing suicide every day
 
I’m pissed I lost my adrenaline receptors. Now I’m scared of death in a weird way.
I died last year and I’m not meant to be here but something kept me here. What if the same thing happens again. I won’t have any adrenaline to kick in as god intended in my brain
 
maryjaneforever said:
I’m pissed I lost my adrenaline receptors. Now I’m scared of death in a weird way.
I died last year and I’m not meant to be here but something kept me here. What if the same thing happens again. I won’t have any adrenaline to kick in as god intended in my brain
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It's the same I no longer have adrenaline the only thing I feel sometimes is stress and fear when I get stopped by the cops
 
Yup, that no talking/yes no answers phase lasted about a month and a half for me. Kept thinking they would see how sick I was and stop the medication, but no one seemed to care, even family. "Why are you always just lying down with eyes closed" they would say. Ohh, I don't know it started with the medication, maybe it's that, huh? The doctor just kept saying "medication takes time to work/adjust".

I was convinced I was a pedophile or murderer at some points, because was only things I could imagine being treated so badly. Thought place was some sort of off the record torture facility for serious offenders.
 
fenec said:
It's the same I no longer have adrenaline the only thing I feel sometimes is stress and fear when I get stopped by the cops
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You have some adrenaline. Haldol is a agonist for a2, whereas invega is not.
You also have inverse agonist at d2 d3 d4
You also get an agonist at 5HT1a which is a bonus.


Invega is a antagonist of
5-HT1A617
5-HT2A1.1
5-HT2C48
5-HT5A278
5-HT62414
5-HT72.7
α1A2.5
α2A3.9
α2C2.7
D141
D21.6
D33.5
D454[29]
D529
H119
H2121
mACh>10,000
Values are Ki (nM). The smaller the value, the




Haloperidol binding profile
ReceptorActionKi (nM)
D1silent antagonistUnknown efficiency [citation needed]
D5silent antagonistUnknown efficiency[citation needed]
D2inverse agonist0.7[60]
D3inverse agonist0.2[61]
D4inverse agonist5–9[62]
σ1(irreversible inactivation by haloperidol metabolites)3[63]
σ2agonist54[64]
5-HT1Aagonist1,927[65]
5-HT2Asilent antagonist53[65]
5-HT2Csilent antagonist10,000[65]
5-HT6silent antagonist3,666[65]
5-HT7irreversible silent antagonist377.2[65]
H1silent antagonist1,800[65]
M1silent antagonist10,000[65]
α1Asilent antagonist12[65]
α2AAgonist1,130[65]
α2BAgonist480[65]
α2CAgonist550[65]
NR1/NR2B subunit containing NMDA receptorantagonist; ifenprodil siteIC50 – 2,000[66]
 
okthen said:
How long to feel anything from weed?
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I never really lost it, but it went way down after I got PSSD and it took a year and a half to get back to old sensitivity to it. I'm just missing some euphoria, but I do feel euphoria from it, but just in the beginning.
 
maryjaneforever said:
You have some adrenaline. Haldol is a agonist for a2, whereas invega is not.
You also have inverse agonist at d2 d3 d4
You also get an agonist at 5HT1a which is a bonus.


Invega is a antagonist of
5-HT1A617
5-HT2A1.1
5-HT2C48
5-HT5A278
5-HT62414
5-HT72.7
α1A2.5
α2A3.9
α2C2.7
D141
D21.6
D33.5
D454[29]
D529
H119
H2121
mACh>10,000
Values are Ki (nM). The smaller the value, the



Haloperidol binding profile
ReceptorActionKi (nM)
D1silent antagonistUnknown efficiency [citation needed]
D5silent antagonistUnknown efficiency[citation needed]
D2inverse agonist0.7[60]
D3inverse agonist0.2[61]
D4inverse agonist5–9[62]
σ1(irreversible inactivation by haloperidol metabolites)3[63]
σ2agonist54[64]
5-HT1Aagonist1,927[65]
5-HT2Asilent antagonist53[65]
5-HT2Csilent antagonist10,000[65]
5-HT6silent antagonist3,666[65]
5-HT7irreversible silent antagonist377.2[65]
H1silent antagonist1,800[65]
M1silent antagonist10,000[65]
α1Asilent antagonist12[65]
α2AAgonist1,130[65]
α2BAgonist480[65]
α2CAgonist550[65]
NR1/NR2B subunit containing NMDA receptorantagonist; ifenprodil siteIC50 – 2,000[66]
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No I don't have adrenaline I'm speaking to you knowingly to drive at full speed with my car at full speed and I don't have adrenaline he says that it blocks dopamine serotonin but in my opinion what happens must do more that blocking simply blocks dopamine etc. it must go throughout the brain and do a lot of damage we are simply lobotomized
 
fenec said:
No I don't have adrenaline I'm speaking to you knowingly to drive at full speed with my car at full speed and I don't have adrenaline he says that it blocks dopamine serotonin but in my opinion what happens must do more that blocking simply blocks dopamine etc. it must go throughout the brain and do a lot of damage we are simply lobotomized
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I have the same side effect as you I'm not hungry I'm not thirsty I don't feel I'm tired I have exactly the same side effects as you libido problem everything
 
It’s like comparing olanzapine.
They get a full agonist at 5HT5A.

I just showed you that you get an agonist at a2 and 5HT1A.

Any serotonin is a bonus.
Dopamine is what we all need. Everything blocks dopamine.

I’d be happy for an agonist of anything at this point.

Olanzapine[72]
SiteKi (nM)ActionRef
SERTTooltip Serotonin transporter≥3,676ND[72][73]
NETTooltip Norepinephrine transporter>10,000ND[72]
DATTooltip Dopamine transporter>10,000ND[72]
5-HT1A2,063–2,720Antagonist[74][75]
5-HT1B509–660ND[72][75]
5-HT1D540–1,582ND[72][75]
5-HT1E2,010–2,408ND[72][75]
5-HT1F310ND[75]
5-HT2A1.32–24.2Inverse agonist[76][77]
5-HT2B11.8–12.0Inverse agonist[78][79]
5-HT2C6.4–29Inverse agonist[77][79]
5-HT3202Antagonist[72]
5-HT5A1,212Full Agonist[72]
5-HT66.0–42Antagonist[72][80]
5-HT7105–365Antagonist[72][81]
α1A109–115Antagonist[72][74]
α1B263Antagonist[72]
α2A192–470Antagonist[75][81]
α2B82–180Antagonist[74][75]
α2C29–210Antagonist[74][75]
β1>10,000ND[72][75]
β2>10,000ND[72][75]
D135–118Antagonist[77][81]
D23.00–106Antagonist[82][83]
D2L31–38Antagonist[75][77]
D2S21–52Antagonist[75][84]
D37.8–91Antagonist[82][83]
D41.6–50Antagonist[82][73]
D4.217–102Antagonist[85][86]
D4.421–60Antagonist[84]
D574–90Antagonist[72][77]
H10.65–4.9Inverse agonist[72][75]
H244Antagonist[72]
H33,713Antagonist[72]
H4>10,000Antagonist[72]
M12.5–73Antagonist[87][88]
M248–622Antagonist[80]
M313–126Antagonist[79][80]
M410–350Antagonist[80][87]
M56.0–82Antagonist[80][87]
σ1>5,000ND[75]
σ2NDNDND
Opioid>10,000ND[75]
nAChTooltip Nicotinic acetylcholine receptor>10,000ND[72]
NMDA
(PCP)		>10,000ND[72]
VDCCTooltip Voltage-dependent calcium channel>10,000ND[72][75]
VGSCTooltip Voltage-gated sodium channel>5,000ND[75]
hERGTooltip Human Ether-à-go-go-Related Gene6,013Blocker
 
Does anyone have any positive things to say that they are seeing in their recovery? I really want to know I’ll get better. Only one month out of recovery, losing my patience already.
 
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Ayden said:
Thx. Would taking adderall pretty high dose (60mg) a few times have done anything to my recovery? Didn't feel anything from it unless I took 60mg
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If you can feel it at all that’s a good sign bro don’t take it anymore tho you’ll take a few more months to heal from haldol then invega
 
jrsteez said:
Does anyone have any positive things to say that they are seeing in their recovery? I really want to know I’ll get better. Only one month out of recovery, losing my patience already.
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Yep! I felt like a blank sheet of paper/TV static for months on end. Total anhedonia. I couldn't feel my orgasms. I couldn't feel anything at all. Aphantasia. I couldn't think. I just felt like I was locked inside of a mind prison, deprived of senses. I had no personality. Almost any symptom of invega and PSSD you can think of.

Almost all of it is gone now. I just have some loss of erogenous sensation, low libido, some erectile tissue problems, and a little emotional blunting but I do have feelings. Everything else is nearly back to normal after 1 year and 5 months. I'm sure I would be completely normal by now if I didn't try Prozac.
 
InvegaAnon said:
Yep! I felt like a blank sheet of paper/TV static for months on end. Total anhedonia. I couldn't feel my orgasms. I couldn't feel anything at all. Aphantasia. I couldn't think. I just felt like I was locked inside of a mind prison, deprived of senses. I had no personality. Almost any symptom of invega and PSSD you can think of.

Almost all of it is gone now. I just have some loss of erogenous sensation, low libido, some erectile tissue problems, and a little emotional blunting but I do have feelings. Everything else is nearly back to normal after 1 year and 5 months. I'm sure I would be completely normal by now if I didn't try Prozac.
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Wow it really takes so long to recover. I had 5 shots I’m hoping to see some improvements at least by the end of this year. I believe I’m going to start St. John’s Wort soon to help out.
 
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