Mental Health Coming off Invega/Xeplion (paliperidone) injections v 8.0

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End of Month 5 Update:

I wish I had better news, but it could be worse I guess. I feel like I fucked up my recovery by trying Prozac and then taking lion's mane immediately afterward. I hope I don't have PSSD, but the symptoms of bad reactions lion's mane and Prozac withdrawl and PSSD all overlap. I'm dealing with very muddy water here. I chose Prozac because I thought it wouldn't cause as many sexual side effects and there were posts that were like "Oh yeah, if you're only on 10mg you can still smoke weed, it's fine." Turns out people with ADHD don't process Prozac well, and I also have mild NAFLD. It was very much the wrong drug for me and I wish I had spoken to a smarter psychiatrist. On top of that I was smoking weed and was only a few months off of mania from Straterra. What a mistake.

Sensation and sex drive came back 10 days after I quit Prozac, then my sex drive was cut down again by one 5mg of Abilify and two 10mg of Zyprexia. I'm not currently taking those. Drive came back again when Abilify left my system, but weaker. I was over a week into taking lion's mane at the time, I thought things were going fine.
I was taking 1000mg of extract, which may have been too much for me. I was sleeping better and I had a clear head. I was attempting to be creative. My memory had improved.

That all changed in the third week. I had all of the bad effects of lion's mane, but I had no idea what was happening because there isn't a lot of awareness about that sort of thing. I had a lot of brain fog and I couldn't follow anything. I thought symptoms from invega were acting up again! Then I thought "Oh, is this the Prozac withdrawl finally hitting me?" I continued to take it.
My body temperature spiked, I started to disassociate, I felt physically numb. I lost sensation in my genitals, but then I was fine the next day. I thought "That was weird." and kept taking it because I felt like I had to in order to prevent dementia that could be caused by invega. The next night was even worse, my life didn't feel like my life. I felt like my personality and emotions were gone again. My genitals went completely numb exactly like after my injections. Then I searched "lion's mane genital numbness" and I found a post on Reddit warning about the effects of lion's mane. It's a very rare side effect, but it can happen.

These days were followed by extreme anxiety, insomnia, and a sense of impending doom. I wanted to give up on my career and I somehow managed to apply for a job because I decided to give up on art. I was very suicidal. I was also completely anhedonic and swimming, going for walks, taking baths and playing video games all made me horribly anxious. I couldn't do anything but panic constantly. The post I read gave me the impression this would be permanent or long-term, but thankfully most of these horrible feelings and anhedonia have passed.

CW suicidal behavior-

<edited out method info - SMod> , but it wasn't an actual attempt. Just a "Let's see if I could do it." I couldn't feel any attachment to my friends and family and I didn't care if I died. Now I get emotional again when I think about how they would react if I killed myself and it frightens me that I couldn't feel that. I'm no longer suicidal.

- End of discussion of suicidal behavior.

I'm getting emotional as I write this and I'm taking that as a sign my emotions are coming back again. I can think more clearly. I'm obsessively googling and checking my genitals all day though.

My sensation is at 80%, my libido is at 10% two and a half weeks later. The timeframe for this recovery makes more sense for lion's mane sexual dysfunction rather than PSSD, so I would rather think it's that for now. I don't need anyone telling me "well actually it sounds like you have PSSD now" so please back off on diagnosing me. I had an acceptable masturbation session after drinking some coffee, but coffee seems to have only worked well once.

My clitoral erections are getting stronger/longer (although today I'm pretty squishy, I did waaay too much checking yesterday) and my orgasms have ups and downs. I had clit shrinkage and vagina slackening, but most of that is gone now. My emotions and anhedonia are also improving quickly. I was having good orgasms just before lion's mane turned on me. I hope it's not PSSD and just a bad reaction to lion's mane. PSSD onset doesn't include full body numbness and extreme suicidality so I think it's the lion's mane. But like I said, it's really unclear right now and I would appreciate it if no one made a comment on weather or not it's PSSD.

It's also hard to say where my recovery is in general because of all this shit. I should have a clearer picture by the October update. I will say my tremor has gone away and my coordination has returned. I remember how to draw again.

I think lion's mane messed with my hormones a lot. I had a hormonal panel done only 10 days in and my progesterone was at 0.2. It was at 0.7 when I had it tested again exactly a month later. It must have hit rock bottom. Low progesterone with estrogen dominance can cause genital numbness. It typically happens to menopausal people.

It also hit my thyroid hormone, which had been bad before but it had been stable for a year now. I had tests run because I thought mercury poisoning was possible.

My testasterone was in normal AFAB range, which is really surprising to me considering how hairy I am among other signs of naturally high testasterone. So I think it made my testasterone go down as well. It seems to impact the hormones of people who have anemia and whoops, I just got my yearly ulcerative colitis labs done too and I'm anemic again! I probably also still have slightly high prolactin. It also made my white blood cell count go up and I got a bruise when I injected my Humeria and got blood drawn. I've since injected my medication and had blood drawn with no bruising.

I have quit smoking weed for now because I'm afraid it's going to hurt my sex drive and it made me disassociate a lot after lion's mane.

I think lion's mane can help some people, but please be cautious if you decide to take it.

Don't take lion's mane if:

Your hormones are still imbalanced from invega
You're anemic or have a history of anemia
You have an autoimmune disease
You have NAFLD or other liver issues. (I think it built up in my system too much, my breath and pee smelled like mushrooms for weeks)
You have depersonalization/derealization disorder
You are taking a medication that raises norepinephrine levels (I think my norepinephrine got waaaay too high since guanfacine raises it, so does lion's mane)

Lion's mane side effects I got:

Physical numbness
Emotional numbness
Disassociation
Extreme anxiety
Insomnia
Sexual dysfunction
Genital numbness
Anhedonia accompanied by panic when doing things I liked doing
Loss of coordination

All of this is going away. I've been playing No Man's Sky and watching Star Trek again and enjoying it. I can pay attention again. The newer emotional blunting caused by prozac and lion's mane is improving and my life feels like it belongs to me again.

Wish me luck in bouncing back. I think that's all I have to say this month. If the universe is a simulation, whoever is running my personal simulation is probably like "They keep getting poison damage! Aaahh!"

Like last month, I leave you with a song that is helping me get through all of this.

 
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Guys I’m so scared I won’t recover my 0 sex drive, it seems like not many people have gotten this symptom. Most people have a tiny one. I’m so suicidal and I literally cry what I can. Please send help
 
Guys I’m so scared I won’t recover my 0 sex drive, it seems like not many people have gotten this symptom. Most people have a tiny one. I’m so suicidal and I literally cry what I can. Please send help
*sigh* I had no sex drive, but it was one of the first things to start to recover for me. I just ruined it with other medication and lion's mane, hopefully temporarily.

Actually, I think most people don't have any sex drive on this stuff. People just don't talk about it as much.
 
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*sigh* I had no sex drive, but it was one of the first things to start to recover for me. I just ruined it with other medication and lion's mane, hopefully temporarily.

Actually, I think most people don't have any sex drive on this stuff. People just don't talk about it as much.
Up until when did you have 0 sex drive
 
Guys I’m so scared I won’t recover my 0 sex drive, it seems like not many people have gotten this symptom. Most people have a tiny one. I’m so suicidal and I literally cry what I can. Please send help

Can you become arroused at all, in terms of having an errection ?
 
My symptoms are in and out at this point , I experience windows and feel strongest in the morning and at night. Mid day is tough
 
What are the major signs of recovery ? Can we address key points? Is it feeling substances and ahedonia going away with positive emotions ?
 
What are the major signs of recovery ? Can we address key points? Is it feeling substances and ahedonia going away with positive emotions ?

I don't really know how to describe it aside from just starting to feel like myself again. I'm still kind of low energy but that might be a result of the trauma as opposed to the medication itself.
 
I'm tapering off of guanfacine to deal with the emotional blunting and loss of libido from lion's mane. I'm going to go back on it when stuff goes back to normal since it seems to make both of these things worse.

I'm getting a familiar ache in my ovary and I hope that means I'll have a period. I hate having periods because of gender dysphoria, but at least it means my hormones are going back to normal. If not this month, then maybe next month.
 
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I got the 2 initiation doses off Invega Sustenna. Been 2 months since the horrid side effects and td symptoms and drooling. Luckily my libido is slowly returning, I can feel that emotional numbness caused by the drug slightly weaken. But it's been so long since I've felt any dopamine other than marijuana. How much longer do I have to wait before this drug wears out my system?
Also the td symptoms, drooling, and visual effects are completely gone but I still have some slight anhedonia probably because the drug is still in my system. Any idea when this drug completely exits the system, it's already been 9 weeks roughly.
 
Nothing feels good to me. Even sleeping is not as pleasurable as before. I'm still sexually disfunctional. I wonder if i will ever go back to normal. :(

Is it possible to heal? Cause the way it feels this thing seems permanent. I haven't felt any improvements ever since i got off the drugs.
 
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I’m feeling very suicidal I can’t get over the fact that I am just an empty shell what I used to be. No drive no motivation lack of strength my personality everything gone. It’s been 7 months and by now I should be almost healed but I’ve just made some gradual progress. What’s the point of living life if you have been lobotomised
Please hang in there. Please just give yourself time to heal ❤

The anhedonia is definitely fading for me on month 4. Only initial shot. There is progress. Running every day , 10,000 plus steps , going to apply for an easy job
This is excellent to hear! Keep doing what you're doing 🙂

Has anybody recovered from 0 sex drive
Guys I’m so scared I won’t recover my 0 sex drive, it seems like not many people have gotten this symptom. Most people have a tiny one. I’m so suicidal and I literally cry what I can. Please send help
Almost everyone I've read experiences from on here gets the sexual dysfunction side effect. You are definitely not alone. And from what I have read, it does recover, it just takes time.

I got the 2 initiation doses off Invega Sustenna. Been 2 months since the horrid side effects and td symptoms and drooling. Luckily my libido is slowly returning, I can feel that emotional numbness caused by the drug slightly weaken. But it's been so long since I've felt any dopamine other than marijuana. How much longer do I have to wait before this drug wears out my system?
Also the td symptoms, drooling, and visual effects are completely gone but I still have some slight anhedonia probably because the drug is still in my system. Any idea when this drug completely exits the system, it's already been 9 weeks roughly.
From everything I have read, 9 weeks is still early days in terms of recovery from 2 shots of Invega. Everyone seems to recover in different time frames so just take it each day at a time and you will eventually start to notice the side effects going away even more.

Nothing feels good to me. Even sleeping is not as pleasurable as before. I'm still sexually disfunctional. I wonder if i will ever go back to normal. :(

Is it possible to heal? Cause the way it feels this thing seems permanent. I haven't felt any improvements ever since i got off the drugs.
Almost every single person in these threads has recovered. I know right now it feels like it's going to be permanent, but it won't be. Give it time, eat healthy, drink plenty of water, try to exercise a little bit every day, socialise if you feel comfortable and safe doing so, and you will start to recover. How long have you been off Invega now?
 
Do you guys think adding Zoloft could be causing a head tick because the dopamine from the Zoloft is blocked ?
 
What are the major signs of recovery ? Can we address key points? Is it feeling substances and ahedonia going away with positive emotions ?

For me i had no problem feeling weed on invega or clonazepam that time my mom gave me some of hers in the psych ward.

Anhedonia was the first thing to start to go away for me when i finally got off the abilify injections that where just as bad as invega for me. My sex drive was about the first thing to come back which took about 3 or 4 months i think. Then i slowly started feeling better and getting more energy. However my full recovery was delayed quite abit because i was on latuda and got horrible akathesia and znxiety from it so i eventually switched to zyprexa and am doing great. I now feel normal shit like abit tired during the day and i have not only kept the weight off but have packed on 20lbs of muscle from lifting weights.
 
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