Recent studies from recent years (such as long-term neuroimaging follow-up studies published in JAMA Psychiatry and Molecular Psychiatry) indicate that prolonged use of antipsychotic medications, especially at high doses, may be associated with a slight reduction in brain volume (primarily in gray matter).
Key Sources and Literature
Below are evidence-based sources from the medical literature for further reading:
Longitudinal & Imaging Studies (JAMA Psychiatry / Archives of General Psychiatry):
Ho et al. (2011) – "Progressive Brain Volume Changes During the Early Course of Schizophrenia" (published in Archives of General Psychiatry). A long-term follow-up study showing a correlation between cumulative antipsychotic dose and changes in gray and white matter volume.
Meta-Analyses & Review Studies (Molecular Psychiatry / Schizophrenia Bulletin):
Radua et al. (2015) – "Voxel-based meta-analysis of grey matter changes in first-episode schizophrenia" (published in Schizophrenia Bulletin). Examines brain volume changes in first-episode psychosis patients compared to the effect of treatment.
Fusar-Poli et al. (2013) – "Progressive brain changes in schizophrenia: a meta-analysis of structural MRI studies" (published in Neuroscience & Biobehavioral Reviews). Analyzes structural brain change progression and evaluates medication effect versus disease effect.
He know AP’s shrink the brain, cause severe mental and physical effects and it cause functional brain damage, his job as a moderator inside this thread is to keep people respecting rules and maybe also keep them alive by giving some hope.
As you can see every moderator here is still on AP’s or heavy street drugs, there are very few people who din’t had psychosis but got injected anyways, as far as i remember right me, matthew and someone else who i can’t remember the name due to the severe cognitive fog/deficit due to the injections.
I was at your place at 13 months, it was september of 2025, i joined this thread and they keept telling me “you will recover, it take times, stay busy, we alll heal in different timelines”.
You have post neuroleptic syndrome or NIDS (Neuroleptic Induced Deficit Syndrome), actually NIDS only refer to cognitive issue but the reality is that NIDS have impact on almost everything, someone can only have cognitive deficits, someone else can have cognitive deficits with vision issues with tinnitus with no strenght to even brush his how teeth and a complete loss of basic function..
NIDS it’s a sweet way to call the brain damage, because saying “functional brain damage due to AP’s injections” don’t sound good at all.
Everyone Who have persistent sympthoms 2-3 months after the injections has the NIDS, not every NIDS is the same, some are softer, other are harder and more complex.