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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 10

Matthew01 said:
Are you sure wellbutrin would work? The injection they gave you sounds like it has a very high affinity level. Don't you need something with a high affinity level so that it would compete and replace it? It sounds like those drugs would do nothing to help.What do you think about this?
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bro i have no idea what ur talking about, whatever u learned from receptors or the brain are just theories, the brain could very well work very differently.
 
IOSIP said:
Your mad if you take abilify for anhedonia. But what would i know its not my life. But crazzzzzy idea my man.
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Bro but i read like 4 or 5 studies where ppl said it helped them, idk i havent fully decided but if i do it will be a very low dose less than 5mg , anything above 10 will be just like invega
 
TonyTonyChopper said:
bro i have no idea what ur talking about, whatever u learned from receptors or the brain are just theories, the brain could very well work very differently.
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Let me explain it so you could understand. Affinity is how much strong a dopamine agonist binds to a dopamine receptor. The injections you took probably binded to a dopamine receptor really strongly and it may diminished or make the effect of the wellbrutin worthless because it is blocked by a dopamine antagonist. Don't you think you need something of a stronger affinity so it would at least have an effect? That is what I'm asking. You want that works immediately, right?
 
So it’s been a little over 6 months since my last shot. My anhedonia is still bad I can’t watch TV for more than 2 minutes without checking my phone or something. My dissociation is still extremely extremely bad. It feels like this drug gave me schizophrenia because I feel so disconnected from reality.

My muscle stiffness and twitches have gotten a little bit better, but the progress is so slow that it almost doesn’t seem worth it.

I think I will end up dying soon. And it sucks.
 
TonyTonyChopper said:
Bro but i read like 4 or 5 studies where ppl said it helped them, idk i havent fully decided but if i do it will be a very low dose less than 5mg , anything above 10 will be just like invega
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Pay attention to the study, it may be a psychiatrist's collaborator, so it's still an antipsychotic and therefore money for their pocket.
 
rawbanana said:
So it’s been a little over 6 months since my last shot. My anhedonia is still bad I can’t watch TV for more than 2 minutes without checking my phone or something. My dissociation is still extremely extremely bad. It feels like this drug gave me schizophrenia because I feel so disconnected from reality.

My muscle stiffness and twitches have gotten a little bit better, but the progress is so slow that it almost doesn’t seem worth it.

I think I will end up dying soon. And it sucks.
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I haven't seen any clear improvement after 1 year, but I assure you that it's going in the right direction everything's coming back physical libido sperm white orgasm everything's coming back in everything I feel 80% 90% cured after 22 months of stopping I received 4 haldol injections especially if you're young the brain repairs itself much faster
 
Update on me taking St John's Wort daily: I developed a pulsing feeling on the joints on my back in two places. I stopped taking it, and they went away. I did feel like mentally I was doing better, but I don't want to get Tardrive whatever so I'll stop.
 
fenec said:
I haven't seen any clear improvement after 1 year, but I assure you that it's going in the right direction everything's coming back physical libido sperm white orgasm everything's coming back in everything I feel 80% 90% cured after 22 months of stopping I received 4 haldol injections especially if you're young the brain repairs itself much faster
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Yeah. I just hate sitting and waiting. It’s hard going through life when everything feels totally meaningless. Life was hard enough as it was. This on top of it all is just torture. Pure torture.
 
Matthew01 said:
Let me explain it so you could understand. Affinity is how much strong a dopamine agonist binds to a dopamine receptor. The injections you took probably binded to a dopamine receptor really strongly and it may diminished or make the effect of the wellbrutin worthless because it is blocked by a dopamine antagonist. Don't you think you need something of a stronger affinity so it would at least have an effect? That is what I'm asking. You want that works immediately, right?
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Hey, so you still think you need something of stronger affinity so it wouldn't have an effect and not be blocked out? Also I going to the doctor tomorrow, can you advice me on what to say? I'm planning to suggest him apomorphine and cabergoline for me. I've already researched the interaction and it says apomorphine reduces the thereupitic efficacy of clopixol so it might help me I think. Can anyone give me advice? Are there any kind of drugs that may help?
 
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