• The Dark Side 💕 Welcome Guest 💕
    Posting Rules Bluelight Rules
    Notable Threads Urgent Hotlines
    Bereavement Mindfulness
    Suicide Support Anger Management
  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Mental Health Coming Off Invega Sustenna (Paliperidone) v4

Status
Not open for further replies.
Afernandes1 said:
It’s actually good that you pee a lot. Invega is excreted from the system via urination. So the more you pee, the quicker it leaves your system.
Click to expand...
It might be excreted a little but only acutely. The injection is just sitting in your muscle (where it was injected) and the drug is slowly being released to the bloodstream over the course of couple months (or however long it might be). There's nothing you can do to get it out you faster.
 
LivingOnValium said:
It might be excreted a little but only acutely. The injection is just sitting in your muscle (where it was injected) and the drug is slowly being released to the bloodstream over the course of couple months (or however long it might be). There's nothing you can do to get it out you faster.
Click to expand...
This is from www.medicinenet.com
  • Invega Trinza is metabolized by liver enzymes. Drugs that increase the action of these enzymes such as carbamazepine, phenytoin, rifampin, and St. John's wort will decrease blood levels of Invega Trinza thereby decreasing its effect.
  • Invega Trinza blocks the effect of dopamine in the brain while dopamine agonists such as levodopa increase the levels of dopamine in the brain.
  • Combining these agents is not recommended since the effect of both drugs will be reduced.
 
1NV3GA1STH3D3V1L said:
This is from www.medicinenet.com
  • Invega Trinza is metabolized by liver enzymes. Drugs that increase the action of these enzymes such as carbamazepine, phenytoin, rifampin, and St. John's wort will decrease blood levels of Invega Trinza thereby decreasing its effect.
  • Invega Trinza blocks the effect of dopamine in the brain while dopamine agonists such as levodopa increase the levels of dopamine in the brain.
  • Combining these agents is not recommended since the effect of both drugs will be reduced.
Click to expand...
That's Invega Trinza dude. You're talking about Paliperidone hydrochloride, which is what is in the tablets. This thread is about INVEGA SUSTENNA which the injectable form (Paliperidone palmitate).

This from the manufacturer's website:
  • After a single IM injection of PP1M, plasma concentrations of paliperidone gradually rise to reach observed maximum plasma concentration (Cmax) at a median time to reach the maximum plasma concentration (tmax) of 13 days.1 Release of paliperidone starts as early as one day after the injection and lasts for as long as 126 days.1 The median plasma elimination half-life (t½) of paliperidone following PP1M administration over the dose range of 39-234 mg is 25-49 days.

Pharmacokinetics of INVEGA SUSTENNA

A summary of pharmacokinetics of INVEGA SUSTENNA® (paliperidone palmitate 1-month).
www.janssenmd.com www.janssenmd.com
 
LivingOnValium said:
That's Invega Trinza dude. You're talking about Paliperidone hydrochloride, which is what is in the tablets. This thread is about INVEGA SUSTENNA which the injectable form (Paliperidone palmitate).

This from the manufacturer's website:
  • After a single IM injection of PP1M, plasma concentrations of paliperidone gradually rise to reach observed maximum plasma concentration (Cmax) at a median time to reach the maximum plasma concentration (tmax) of 13 days.1 Release of paliperidone starts as early as one day after the injection and lasts for as long as 126 days.1 The median plasma elimination half-life (t½) of paliperidone following PP1M administration over the dose range of 39-234 mg is 25-49 days.

Pharmacokinetics of INVEGA SUSTENNA

A summary of pharmacokinetics of INVEGA SUSTENNA® (paliperidone palmitate 1-month).
www.janssenmd.com www.janssenmd.com
Click to expand...
No, you're incorrect, once again. I am talking about Invega Trinza (paliperidone palmitate) the 3 month injection which is way more potent than Invega Sustenna. Try a 3 month 819mg LAI versus a 1 month 156mg or 234 mg LAI. Which one do you think is worse?

Again, from www.medicinenet.com, the title of the article "Side Effects of Invega Trinza (paliperidone palmitate)" I am not talking about Invega pills.

And again:
  • Invega Trinza is metabolized by liver enzymes. Drugs that increase the action of these enzymes such as carbamazepine, phenytoin, rifampin, and St. John's wort will decrease blood levels of Invega Trinza thereby decreasing its effect.
 
1NV3GA1STH3D3V1L said:
No, you're incorrect, once again. I am talking about Invega Trinza (paliperidone palmitate) the 3 month injection which is way more potent than Invega Sustenna. Try a 3 month 819mg LAI versus a 1 month 156mg or 234 mg LAI. Which one do you think is worse?

Again, from www.medicinenet.com, the title of the article "Side Effects of Invega Trinza (paliperidone palmitate)" I am not talking about Invega pills.

And again:
  • Invega Trinza is metabolized by liver enzymes. Drugs that increase the action of these enzymes such as carbamazepine, phenytoin, rifampin, and St. John's wort will decrease blood levels of Invega Trinza thereby decreasing its effect.
Click to expand...
Ok, so we are talking about the same thing after all. I was wrong about that but it doesn't matter because it wasn't my point. I actually assumed that you had read what i said in the first post you quoted. That's why i thought you must be talking about a different product. Apparently this is not the case so let's do some revision. I'll try to be a bit more clear this time.

What you fail to understand is that the injection is in the muscle (where it's injected) for months. It will be slowly released in the bloodstream during that time. It cannot be metabolized by those enzymes (or anything at all) you are citing. You can acutely lower the amount of paliperidone in your system by those enzyme inducers you cite (it's not even remarkable anyway). Once those things are out of your system (carbamazepine, phenytoin, rifampin, and St. John's wort etc.) more paliperidone will be released from your muscle (where it was injected) at the same rate as before. There's nothing you can do about it.
 
Last edited:
LivingOnValium said:
Ok, so we are talking about the same thing after all. I was wrong about that but it doesn't matter because it wasn't my point. I actually assumed that you had read what i said in the first post you quoted. That's why i thought you must be talking about a different product. Apparently this is not the case so let's do some revision. I'll try to be a bit more clear this time.

What you fail to understand is that the injection is in the muscle (where it's injected) for months. It will be slowly released in the bloodstream during that time. It cannot be metabolized by those enzymes (or anything at all) you are citing. You can acutely lower the amount of paliperidone in your system by those enzyme inducers you cite (it's not even remarkable anyway). Once those things are out of your system (carbamazepine, phenytoin, rifampin, and St. John's wort etc.) more paliperidone will be released from your muscle (where it was injected) at the same rate as before. There's nothing you can do about it.
Click to expand...
Sir, I’m not failing to understand anything you’re saying. You confirmed my point, which is concerning the reduction of Invega in the bloodstream. And I can tell you from experience, I do not feel the Invega working as strongly as before I took St. John’s Wort. You say it’s not a remarkable change, write an article in a medical journal then.

To everyone else who is not into the whole “let me try to find ways to take away hope and optimism from people,” read this.

http://www.scielo.org.co/pdf/rcp/v49n2/0034-7450-rcp-49-02-84.pdf
 
1NV3GA1STH3D3V1L said:
Sir, I’m not failing to understand anything your saying. You confirmed my point, which is concerning the reduction of Invega in the bloodstream. And I can tell you from experience, I do not feel the Invega working as strongly as before I took St. John’s Wort. You say it’s not a remarkable change, write an article in a medical journal then.

To everyone else who is not into the whole “let me try to find ways to take away hope and optimism from people,” read this.

Click to expand...
Dude you're giving people false hope, not cool. This a quote from the study you just linked here:

In the last 20 years of clinical practice, the senior author has identified these 2 rare cases in which the patients needed extremely high doses of drugs metabolized by CYP3A4 to reach and maintain serum therapeutic concentrations.
Click to expand...

You're now talking about a case study of two rare cases in the last 20 years. Even if you were an anomaly like one of them (that is R-A-R-E) how many other's like that do you think there are going through this thread? I know that it sucks but it's the truth. And I believe it is what people need to hear even though it's not what they want to hear.

And even then it doesn't change the fact that the paliperidone is released from the muscle at a constant rate even if you take St. John's Wort. Even if you can accelerate the elimination of the drug from the bloodstream you cannot do a thing to more of a drug that is constantly coming off from the muscle depot.
 
guys still don't understand that S. Jhon worth (ipericum perforatum) is practically an antidepressant? ? works on the reuptake of serotonin in fact in Italy it is sold as a natural antidepressant, it is obvious that you feel better if you take it in the time you recover from the shots but it is not true that it decreases the blood flow simply you feel it less because you have more serotonin , but in practice it is like taking zoloft, I do not take St. John's wort for this reason because it is like taking an antidepressant, it makes life easier but still creates a brain imbalance and a habit
 
I also believe that the shots are stored in the tissues, in fact the injections on the arm are the injections from which you heal first because by exercising you can eliminate them first, the worst in my opinion are those on the buttock
 
SkavrsXeplion said:
I also believe that the shots are stored in the tissues, in fact the injections on the arm are the injections from which you heal first because by exercising you can eliminate them first, the worst in my opinion are those on the buttock
Click to expand...
They are stored in the tissues. That's what whole mechanism of action is based on. Exercise actually makes a lot more sense than cramming cyp3a4 inducers in your system. When you've received your last shot exercising will help to eliminate the stored drug. However if you will be injected regularly it's a different story.
 
The doctor in this videos says it best. “Drugs taken in conjunction with St. John’s Wort are metabolized more readily. St. John’s Wort renders most medications less effective, sometimes completely ineffective.” Does that sound like a rare case limited to two people?

So which pessimist cares how long Invega is your muscle, if the Invega that is in your bloodstream (the kind that actually contributes to how a person feels) is rendered less effective?

 
SkavrsXeplion said:
guys still don't understand that S. Jhon worth (ipericum perforatum) is practically an antidepressant? ? works on the reuptake of serotonin in fact in Italy it is sold as a natural antidepressant, it is obvious that you feel better if you take it in the time you recover from the shots but it is not true that it decreases the blood flow simply you feel it less because you have more serotonin , but in practice it is like taking zoloft, I do not take St. John's wort for this reason because it is like taking an antidepressant, it makes life easier but still creates a brain imbalance and a habit
Click to expand...
I know that it's at least been assumed that it is an SSRI in the medical community. It's not likely going to be researched further because big pharma can't make profit out of it. It's been proved to be an effective antidepressant though.
 
stormyroom6 said:
guys i was forced to take the shot after a trip to the hospital, my mom forced me to take another one, so ive had to so far. my last injection was about 13 days ago. im moving regions so i can get away from the mental health act under which they force me to take medications, so i won't have to take anymore, i really wish i didnt let my mom force me into getting the second one even when i knew i could move and escape the court order, i regret it as it will be harmful for my recovery progress.

anyways the symptoms im experiencing now are maximum 5-6 hours of sleep per night, if even, maybe less, i can only sleep during the daytime, i fall asleep at 4-8pm and wake up at 12pm and absolutely can not fall asleep again no matter how hard i try. i wake up every 2-3 hours of sleep, multiple times a night. i cannot take naps. i have twitches which i developed after the shot. ocd type. sexual dysfucntion, boners are not as strong and dont come as easily. erections dont get maximum blood flow, feel like penis size has shrunk. overall anhedonia, lack of pleasure, lack of euphoria. i cant feel a buzz from nicotine, i tried cigarettes and they did nothing, absolutely nothing. im guessing its gonna be the same for booze and whatever else.

i have more issues which i haven't listed but i'll get to it. my most distressing symptom is the sleep part, it affects my mood and my psyche greatly i just wanna be able to sleep properly and nap. i've heard this symptom doesn't go away for a long time. does anyone have experiences with this? have u recovered from the sleep symptoms? how long does it take? please let me know as it is very important to me.

how long will it take until i can feel cigarettes again? and booze? i dont smoke weed but im guessing thats a no go too. is the damage to the receptors permanent. does invega do any sort of permanent damage at all or is it all recoverable? i havent been able to rest easy for a month now since i got the shot, longer than a month now, i have anxiety and depression all day long and can't be happy. ive been in distress since i got the shot. my life is ruined, invega ruined my life, i think about it everyday, i cant sleep, i can be happy. all i think about is the shot. i was perfectly happy and normal before the shot, my symptoms were under control. i had no side effects from the oral mediaction. then i was hospitalized for an issue unrelated to schizophrenia and they took that opportunity to section me and keep me there for 2 weeks and told me i cant leave unless i take the injection, i told the doctor i didn't want it and he came back and said its a discharge condition now. i truly feel like they ruined my life

on another note, they are forcing me to take the shots under court order now but if i leave the province then the act that makes me have to take the injections no longer applies to me anymore so im leaving the province in a week. after i leave and escape the injection, im gonna find a lawyer and try to sue the doctors who made me take this drug even though my symptoms were under control with my previous medication and i had no relapse, and was hospitalized unrelated to schizophrenia. they had to just cause to give me this injection whatsoever. i truly feel like they ruined my life. would a lawyer be able to help me? can i sue?

im just now starting my recovery journey and am still under the effects from my last shot, so i will stick around this thread for a long long time, throughout my recovery journey, ill be active here, this is my first post and its a new thread how coincidental. anyways i would be very very happy if you guys could answer my questions, ive been under alot of stress this past month and am lost and feeling hopeless. is there a way out?
Click to expand...
I just had my second shot yesterday and after reading everything people are saying I realized this was what is causing me a lot of side effects, im super scared of what it’s doing to me I have tremors on my body when talking to people, have twitches and my sex drive and boners are so ruined right now . How long before I feel normal again? I heard it blocks dopamine receptors so how can I know if it’s doing more stuff to me? I’m super unexcited for a lot of stuff and all I want to do is lay in bed, but even ruined my sleep because I feel as if I were awake the entire time I try and go to sleep, and actually am awake moving around to the sides during my Time in bed. I have to take viagra to have at least some of the sex back with my girlfriend but still feel as if something is off. It was a 100mg shot i really feel betrayed by my psychiatrist . I was on ketamine and had a unconscious state that my parents noticed so I had to go to rehab, and one of the things they prescribed for me was this evil shit for this (according to the psychiatrist that i think has no idea what he is done to me ) ¨condition¨ and have been treated for “bipolar” disorder ever since. I’m also taking Wellbutrin and lamotrigine (update I stopped taking it and taking pregabalin low dose)for his therapy, I feel as if I want to be in bed all the time. I aso want to know what to do because I just got it and they have told me it doesnt go away in one month either. No drugs so far have any effect on me, barely benzos.And they were the only thing calming me down from the idea of having the invega iin my system. I want to take higher doses of pregabalin to see how it workss. I am very distressed about this invega situation overall and I would love feedback from people taking it
 
not sure why you people are fighting but i took st john wort's on invega sustenna (monthly injections) and invega trinza (3 months injection) and it is well worth it. st john wort worked for me and it still does with abilify to some extent.

fuck anyone who supports APs. it is a crime.
 
Attention all: I have had to delete multiple comments in this thread that were rude and disrespectful, and were getting off-topic.
This thread is for people to discuss their experiences with the Invega shot, to talk about their grievances and side effects, to share success stories from people who have recovered from the shot, and to support each other.
Please keep any rude comments to yourself, and please do not get in to debates over scientific data. It's fine to share information from studies but please be respectful to others in all conversation exchanges. Anyone who does not show respect to others will receive an official warning.
Peace <3
 
n3ophy7e said:
Attention all: I have had to delete multiple comments in this thread that were rude and disrespectful, and were getting off-topic.
This thread is for people to discuss their experiences with the Invega shot, to talk about their grievances and side effects, to share success stories from people who have recovered from the shot, and to support each other.
Please keep any rude comments to yourself, and please do not get in to debates over scientific data. It's fine to share information from studies but please be respectful to others in all conversation exchanges. Anyone who does not show respect to others will receive an official warning.
Peace <3
Click to expand...
I would say that I missed something reading all these
 
n3ophy7e said:
I believe he chose to go back on it. (Correct me if I'm wrong @Ghost fart ). I guess it works well and is a good option for some people.
Click to expand...
Yeah you got it right. Nothing to correct.

I was 6 months off invega. Started to wander around the city, a bottle or a can always in my hand, shouting stupid shit at everyone.

Cops showed up. Called the paramedics. ER psychiatric evaluation. Talked myself the fuck away but it was difficult.

Invega is literally poison. But it helps me to do shit that most of you do by design. Like buy food, cook it and eat it. Do the laundry. Take showers. Sleep.
 
Status
Not open for further replies.
Top