I have an update and a couple of links to articles I found interesting. It's been a little over 7 months since my two shots of invega. My emotions are coming back, I'm starting to feel pretty human, after losing 15 of the 20 pounds I gained, my weight has stayed pretty stable. In fact, I've been pretty moody ever since I got on birth control, and at this moment I'm feeling kind of angry for no reason (I stopped taking it, but you know). I am in school, nearing the end of the semester in 18 days. I have awesome grades right now, around a 95%, a 97%, a 98%, a 96% and a 90%. However, I am feeling pretty stupid still. I am able to be much more disciplined, but I don't have much creativity, I think very slowly, and I don't often have flashes of insight like I used to. It was really frustrating that I got a 100% on the first test in a class and then got a 75% on the second one, and all my guy friends tried to rub it in my face that they did slightly better. I'm like, great! You did better than a poisoned female schizophrenic! Stick it to the man! My brain was just not working during that exam, and some of my cognitive weaknesses were exposed on one of the questions. I've just started exercising regularly, and I wonder if maybe some of the invega has been releasing into my bloodstream.
I've recently started reading the conflicts of interests at the bottom of studies about drugs. It is EXTREMELY difficult to find studies on antipsychotics where the authors have no financial ties to drug companies, and I have not found even one on paliperidone palmitate that was not funded by Janssen.
There's this whole spate of studies funded by drug companies that you'll see any time you search terms related to the effects of drugs, and if you are not checking the conflicts of interest and financial ties, they can seem like perfectly benign and legitimate studies. I think that a lot of nurses and doctors are fooled by the absolute DELUGE of drug company funded studies, because they just don't think to check where the funding came from every single time. There is also evidence that receiving gifts from drug companies influences doctor's approval of a medication subconsciously, whether they admit it or not. I was looking for a study on discontinuation of antipsychotics that had no conflicts of interest, and this was the one that I found:
https://academic.oup.com/schizophreniabulletin/article/39/5/962/1926273 . Apparently, discontinuing APs can cause an increase in relapses during the first 6-10 months, but that over the long-term, the outcomes were better for those who discontinued. They even explained how the increase in relapses could be due to an over-sensitization of dopamine receptors when someone is being treated with APs. The relapse risk after discontinuation is greater the longer someone has been on APs. This probably isn't surprising to most of you, but I thought it was interesting that not a single study that I found demonstrating the net benefits of maintenance treatment was free of conflicts of interests.
I also thought this article was interesting.
https://www.mentalhealthexcellence....ics-a-case-study-of-institutional-corruption/ The author, Robert Whitaker, examines the evidence provided in a literature review claiming to debunk concerns about the safety and efficacy of antipsychotics. There are a number of glaring issues in the study, which Whitaker summarizes and provides sources for. There is some pretty validating info in some of those sources... like how people use sources which ten years later have been followed up with and shown to be altered in an extremely misleading way.