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Mental Health Coming off Invega (Paliperidone, Xeplion) injections v. 7.0

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The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we report the results of a genomewide scan of schizophrenia families in Iceland; these results support previous work, done in five populations, showing that schizophrenia maps to chromosome 8p. Extensive fine-mapping of the 8p locus and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. NRG1 is expressed at central nervous system synapses and has a clear role in the expression and activation of neurotransmitter receptors, including glutamate receptors. Mutant mice heterozygous for either NRG1 or its receptor, ErbB4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. Furthermore, NRG1 hypomorphs have fewer functional NMDA receptors than wild-type mice. We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia.
 
apsucks said:
The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we report the results of a genomewide scan of schizophrenia families in Iceland; these results support previous work, done in five populations, showing that schizophrenia maps to chromosome 8p. Extensive fine-mapping of the 8p locus and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. NRG1 is expressed at central nervous system synapses and has a clear role in the expression and activation of neurotransmitter receptors, including glutamate receptors. Mutant mice heterozygous for either NRG1 or its receptor, ErbB4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. Furthermore, NRG1 hypomorphs have fewer functional NMDA receptors than wild-type mice. We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia.
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NMDA receptors are what the drug PCP acts on, which PCP is known to mimic intense schizophrenia and psychosis which is interesting cause I don’t think PCP acts on dopamine at all although it may act on glutamate I believe it does if I remember correctly.
 
Merek said:
Ah yes I believe ketamine is what blocks glutamate while also acting on the NDMA receptors, glutamate plays a strong role in how you perceive consciousness so therefore when ketamine blocks it that’s why you feel that dissociative out of body ego death type sensation.
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do you have a learning disablitiy
i took a test showed i have trouble reading a focusing
 
Do you all use other forums and groups like this to talk about your experiences with other people besides here? Just wondering?

<3

<edit - please do not use font styles that may be difficult to read for some members that are already struggling with reading and vision. Thank you - SMod>
 
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If you’re feeling down and want creativity back without drugs/supplements-look 4 tips below the line-
________________________________________

-go to a shopping outlet with anyone (friend, family member, social worker) and buy yourself a new shirt in a bright color. A pop in color or a brand new style will sure to get those creative juices flowing.
  • go on a sidewalk or grass or park and start walking backwards! It’s good ways to use muscles in a different way and it expands creative energy
  • watch a YouTube video of a streamer you’ve never heard of before. A change can bring on a new wave of perception
  • Release emotions through a healing talk with a loved one. Releasing a burden can temporarily allow you feel calm , thus feeling creative with how to turn a negative to positive
 
RecoveryInProgress said:
Do you all use other forums and groups like this to talk about your experiences with other people besides here? Just wondering?

<3
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Tried schizophrenia forums but those guys are completely clueless about antipsychotics and psychiatry...reddit in general is a good forum especially r/antipsychiatry
 
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Serhat96 said:
For those saying AP's don't work; well if illegal drugs increase dopamine & AP's reduce dopamine then it would only make sense that it does work on reducing psychosis, since excessive dopamine is linked to psychosis. Idk why people are shitting on AP's there are alot of people who got benefit out of them yeah I know the side effects sucks of AP's but these neuro scientists, doctors havent worked all their lifes and countless amount of research for a drug that doesn't work or has placebo effects.
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Phaa companies are constantly
pullimg drugs that don't work or kill eple


Those drugs were tested for a decade and still.tirmed out to be bad


Benzos fix psychosis as well as APs do.
APs benefit no one, everyone who tool them would be better off without them
 
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InvegaIsdeath said:
Phaa companies are constantly
pullimg drugs that don't work or kill eple


Those drugs were tested for a decade and still.tirmed out to be bad


Benzos fix psychosis as well as APs do.
APs benefit no one, everyone who tool them would be better off without them
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I disagree with this yes the AP injections are bad but some people do benefit from taking the pills and are better off with them then without them.
apsucks said:
<snip - SMod>
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I watch pretty deviant videos as well when I’m frustrated/sad, I’m not into content about animals but it’s some insane shit just know you’re not alone with that, those videos wouldn’t be out there if people didn’t enjoy watching them it’s normal millions of people view that but are too embarrassed to admit it & trust me there’s people out there who watch way worse stuff then you do millions of them so don’t let your mind tell you you’re a shitty person for viewing that if it ever does.
 
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Hey everyone. I am now 8 months off. I’ve improved drastically since last month. I have my thoughts back to almost normal, I’m making more eye contact, my anhedonia is lifting. I’m almost a functional human being again. The only thing still affected is when I am in a group setting. Can’t think of much to say and I still get anxiety. I can now go to the gym and go for a jog. Working on regaining my strength the where it was. I am telling you it does get better. I can finally see the light at the end of the tunnel. Figuring with how I am healing I see myself recovering at 11-12 months. Feel free to ask me any questions.
 
Invegaishell said:
Hey everyone. I am now 8 months off. I’ve improved drastically since last month. I have my thoughts back to almost normal, I’m making more eye contact, my anhedonia is lifting. I’m almost a functional human being again. The only thing still affected is when I am in a group setting. Can’t think of much to say and I still get anxiety. I can now go to the gym and go for a jog. Working on regaining my strength the where it was. I am telling you it does get better. I can finally see the light at the end of the tunnel. Figuring with how I am healing I see myself recovering at 11-12 months. Feel free to ask me any questions.
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Have you recovered your emotions
 
Invegaishell said:
Hey everyone. I am now 8 months off. I’ve improved drastically since last month. I have my thoughts back to almost normal, I’m making more eye contact, my anhedonia is lifting. I’m almost a functional human being again. The only thing still affected is when I am in a group setting. Can’t think of much to say and I still get anxiety. I can now go to the gym and go for a jog. Working on regaining my strength the where it was. I am telling you it does get better. I can finally see the light at the end of the tunnel. Figuring with how I am healing I see myself recovering at 11-12 months. Feel free to ask me any questions.
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Invegaishell said:
For the most part. I am capable of crying. I can get happy and laugh like before. Not attracted to girls like before however.
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do you think you will recover the not being attracted to being really attracted at soon
 
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