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Mental Health Coming off Invega (paliperidone) injections, v 5.0

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1-MONTH EXTENDED-RELEASE INJECTABLE SUSPENSION: The most commonly reported side effects included akathisia, parkinsonism, insomnia, and headache.

3-MONTH EXTENDED-RELEASE INJECTABLE SUSPENSION: The most commonly reported side effects included increased weight, insomnia, and use of anticholinergic medications (for extrapyramidal symptoms).


AND they are saying it does not cause insomnia, and to find this I searched a lot becauee IT'S hidden. Even more hidden information is that it causes ALL the negative symptoms and it can cause actual psyhosis in healthy individuals who never had it before.
 
pikachu_69 said:
H

Hey Micah, can you tell us if you had invega shots or risperdal shots? If its invega shots how many invega shots did you get? Thanks!
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Risperdal Consta only takes about 10 weeks to clear, given the half life is about 6 days.

Something interesting to note: I always found it interesting that Risperdal Consta has to be kept refrigerated and yet Invega can practically sit out in the hot sun.
 
Wer said:
It is interesting that insomnia caused by invega sus-tena kicked in hardest from 1-2 months off but then it went down to mild-moderate severity range. From 5-6 month it is back to moderate-high severity range, and again it's at high severity at 9 months off. Brain is doing something, question is wtf is actualy happening. Is somebody having similar experience?
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I'm going to start thinking that my psychiatrist is a little right when he told me that there are people who did not feel tired in invega because in my case it has been 5 months sleeping almost 12 hours a day.

Now that I have not taken invega for a month I have started exercising at low intensity at least. On the other hand, since I am in Vraylar, I no longer know what effects are on everything to tell the truth. Anyway it seems that I am much better with Vraylar.
 
kicki said:
I'm going to start thinking that my psychiatrist is a little right when he told me that there are people who did not feel tired in invega because in my case it has been 5 months sleeping almost 12 hours a day.

Now that I have not taken invega for a month I have started exercising at low intensity at least. On the other hand, since I am in Vraylar, I no longer know what effects are on everything to tell the truth. Anyway it seems that I am much better with Vraylar.
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Some info about paliperidone..


Paliperidone(antipsyhotic drug) is sell under brand names: Invega Sustenna/Invega/Xeplion

Paliperidone is a remade of heroin but with opposite and LONG acting effects because of adding F(Fluorine) which makes it long acting antagonist, I will clearify what is antagonist later (this one acts on pre and post synapses).

Molecular structures comparison:

C23H27FN4O3 : Paliperidone
C23H27FN4O2 : Risperidone
C21H23 N1O5 : Heroin

www.drugs.com

Invega Side Effects: Common, Severe, Long Term

Learn about the side effects of Invega (paliperidone), from common to rare, for consumers and healthcare professionals.
www.drugs.com www.drugs.com

1225-Chemical-Synapse.jpg
Receptors explained:
Receptors are recievers on post-synaptic termal which is part of recieving neuron which will produce impulse.

Antagonism is simply put, preventing receptors from working so they can't make neuron to send impulses which we can feel. In case of dopamine neurons, when they trigger, we fell: enjoyment/mood/peace/pleasure/aliveness/feelings.
I'm going to use dopamine system for example, but it works same for all systems.
Humans normally feel enjoyment/mood/peace/pleasure/aliveness/feelings when dopamine chemical binds to a receptors. Dopamine receptors blocked by Invega are not bindable by dopamine. Because dopamine is agonist - when it binds then it goes away from receptors BUT antagonists don't go instantly away from receptor after binding, it stucks for some time, in paliperidone case it's weeks but depends on people. Normaly when dopamine binds, neuron detects it and triggers impulse that we feel as enjoyment/mood/and other stuff what I mentioned. BUT when up to 90% receptors are blocked 24/7 due just one 100mg papliperidone injection, then we get severe depression, anhedonia, lack of enjoyment, restlessness, etc due dopamine neurons not triggering enough because they can't.

Vesicles explained:
Vesicles are like bags for storing specific hormone and they are released when other neuron sends impulse to pre-synapse which then moves the bag to bottom of pre-synapse to release it.

Other neurons decide when to release dopamine from vesicles, invega stucks in vesicles making vesicle have less capacity for dopamine or other blocked hormone.

Dopamine is also used for regulation of muscles and organs( heart, spleen, bowel and pancreas, and some others).

* red circles under spoiler below symbolise big invega molecules doing antagonism on post synapses - receptors and antagonism on pre synapses - vesicles.

20220404-131052.jpg

Here are chemical actions of Risperdal and Paliperidone from pharmacy sources:
Dopamine D1 antagonist
Dopamine D2 antagonist
Dopamine D2L antagonist

Serotonine 5HT2A antagonist
Serotonine 5HT2C antagonist
Serotonine 5HT1D antagonist
Serotonine 5HT1A antagonist
Serotonine 5HT7 antagonist

Adrenergic Alpha-1B antagonist
Adrenergic Alpha-2B antagonist
Adrenergic Alpha-1A antagonist
Adrenergic Alpha-2C antagonist

Histamine H1 antagonist
Dopamine D1 antagonist
Dopamine D2 antagonist
Dopamine D3 antagonist
Dopamine D4 antagonist

Serotonine 5HT2A antagonist
Serotonine 5HT2C antagonist
Serotonine 5HT1D antagonist
Serotonine 5HT1A antagonist
Serotonine 5HT7 antagonist

Adrenergic Alpha-1A antagonist
Adrenergic Alpha-1B antagonist
Adrenergic Alpha-2A antagonist
Adrenergic Alpha-2B antagonist
Adrenergic Alpha-2C agonist

Histamine H1 antagonist
Dopamine D1 : regulates learning, growth of neurons, important part in reward system, regulates memory, attention, impulse control, regulation of renal function, locomotion

Dopamine D1 and D5 : important part of reward system, motor activity, memory, and learning.

Dopamine D2 and D2L: locomotion, attention, sleep, memory, learning, important part of reward system

Dopamine D3: crictical role in cellular and synaptic plasticity throughout brain development, part of feelings system.

Dopamine D4: regulates emotion and complex behavior

Serotonine 5HT2A: visualisation, learning and cognition

Serotonine 5HT2C: mood, feeding, and reproductive behavior.

Serotonine 5HT1D: has effect on CNS, mood.

Serotonine 5HT1A: mood.

Serotonine 5HT7: regulation of sleep, circadian rhythms and mood.

Adrenergic Alpha-1A:
Smooth muscle movement, regulates apetite, stimulates serotonine neurons, regulates saliva secretion.

Adrenergic Alpha-1B:
regulate heart rate and myocardial contractility.

Adrenergic Alpha-2A:
plays a central role in the regulation of systemic sympathetic activity and hence cardiovascular responses such as heart rate and blood pressure. Regulates blood preassure and attention.

Adrenergic Alpha-2B:
Regulates muscles responsible for breathing

Adrenergic Alpha-2C:
Regulates sedation, analgesia, and sympatholytic effects
www.cchrflorida.org

Risperdal: Another Psychiatric Drug Ruining Lives – Citizens Commission On Human Rights, CCHR

Risperdal: Another Psychiatric Drug Ruining Lives
www.cchrflorida.org www.cchrflorida.org
 
Recovery month 9 after 2 shots; I feel ok. Symptoms lessened to a mild state I can manage, I’m not sure how much longer until complete desolation of the substance.
 
Monty! said:
Recovery month 9 after 2 shots; I feel ok. Symptoms lessened to a mild state I can manage, I’m not sure how much longer until complete desolation of the substance.
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Same...month 9 symptoms a bit lessened ,well i feel mostly okay but its not enough for me ...i lost my joy and happiness but not total of it... like i said its beareble i feel okay i think my condition will improve at 1 year mark.i really dunno.
 
Risingson8 said:
Same...month 9 symptoms a bit lessened ,well i feel mostly okay but its not enough for me ...i lost my joy and happiness but not total of it... like i said its beareble i feel okay i think my condition will improve at 1 year mark.i really dunno.
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keep us posted, don't leave the thread
 
Risingson8 said:
Same...month 9 symptoms a bit lessened ,well i feel mostly okay but its not enough for me ...i lost my joy and happiness but not total of it... like i said its beareble i feel okay i think my condition will improve at 1 year mark.i really dunno.
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9 months off and I have no joy, severe depression, severe anhedonia. It is not bearable but I'm surviving. I'm hoping for fast improvements in next 2 years or I'm going to euthanasia with a smile on my face because I can't bear it. Fuc* Earth, probably worst place in whole universe. Suffering like this for years, is simply not worth it.
 
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Fanzy said:
thank you, your progress brings hope. someone like me for example is on the verge of suicide
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Yeah ikr...i was suicidal too like 3 months ago or 2 i couldnt remember...hang in there it will pass...just regular boredom remains instead.And its beareble...
 
I'm being switched to abilify to try and fix my sexual dysfunction. Does anyone here have any experience on abilify?
 
Micah444 said:
Just an update on my progress parkinsonism mostly gone, I’m able to go hard on the rowing machine…cognitive abilities are much improved and I just hit the 14th month without injections. Recovery is definitely possible and I strongly recommend the gym or whatever type of exercise you can handle to help the brain with neurogenesis. My motivation has come back too with me rowing 7 days a week with the goal of losing 8 lbs of fat in 2 months and nothing will stop me. I’m currently prescribed dexedrine so that is helping a lot too. Hang in there guys the hopeless feelings are mostly gone now too. I know what its like in the thick of it fearing it will never end but it does and will. Sending you all positive healing vibes.
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This is so true Invega does cause parkinsonism and it’s definitely 100% drug induced it’s so bad. I remember not been able to stand up in the shower for at least 1 year well. 100% I agree I take Ritalin (50mg) now for my adhd. Funny enough I seen a new psychiatrist last year because I wented to see if adhd was playing a role in my recovery from invega and I told the psychiatrist about my story of been on invega and he was shocked and said I went to hell and back and that I should of never been put on antipsychotics in the first place funny that hey! I was off invega years and years with little to no improvement and stimulates is what improved me a fair bit after having no improvements for so long. The worse part I remember is that early on in the withdrawal of invega is the boredom and the feeling Suicidal all the time for ages and ages but it did go after maybe 3 or 4 months it’s insane this drug is effecting me nearly 5 years on this next month (May) will I fully recover doubtful in my eyes but you never know. :)
 
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