Combining l-deprenyl with ephedrine?

[ebola?]

Individual tolerance varies. During this period, 20 mg of d-amphetamine was spot on for a great time. Curiously, I experienced a reduced ratio of peripheral to adrenergic fx with amps.

I have zero experience with propylhexedrine but from what i have read from erowid it is a direct vasoconstrictor and more potent than adrenaline when it comes to blood pressure and heart rate. I can only imagine the unpleasant feeling of 125mg on 5mg ED deprenyl

The thing is, 125 mg was not outlandish for me, as a prior trial combining deprenyl and ~70 mg propylhexedrine yielded muted effects. For this reason, I consider agents with direct adrenergic activity that are catabolized by maob to simply lack sufficient safety to combine with deprenyl.

The thing about mao-b(and a) inhibition is that sensetivity is exponential to dosage. Say 50% inhibited enzymes does not mean that you can cut synergistic substances in half. This is because there is a large proportion of enzymes that are required for your brain to function normally, so any excess stimulation would cause a huge overrun.

Actually, I'd say that the relationship between maob inhibition and stimulant potentiation varies idiosyncratically by individual, hence the importance of personal titration for any combination being pursued. 3x potentiation is normal, but 10x is not unheard of.

A chart showing how much deprenyl on an empty stomach causes how much inhibition would be nice

This varies too much from trial to trial, let alone between individuals, so no such chart could be constructed.

ebola

 

[nidhogg]

Great stuff.

Individual tolerance is of course the greatest factor when it comes to effective dose. The thing about deprenyl though is that its got a very varying bioavailability. For example being a fat soluable substance bioavailability can increase if taken with fatty food. Then there is the variation of naturally occuring mao-b enzymes in individuals. Despite all there should be enough material to calculate an approximate inhibition and sensitivity increase per stabilized dosage(over a week).

I dont have any deep knowledge about the general metabolism and life of substances. But the way i understood it, mao inhibition should decrease the threshold dosage of affected drugs. As we all know drugs dont work with all dosages instead we have to come over a certain threshold to feel an effect. If this is wrong then i completely understand why mixing deprenyl with adrenergics would be impossible/hazardous

 

[ebola?]

Individual tolerance is of course the greatest factor when it comes to effective dose. The thing about deprenyl though is that its got a very varying bioavailability. For example being a fat soluable substance bioavailability can increase if taken with fatty food. Then there is the variation of naturally occuring mao-b enzymes in individuals. Despite all there should be enough material to calculate an approximate inhibition and sensitivity increase per stabilized dosage(over a week).

Right. This is why I broke my 5 mg / day (with 3 initial 'attack doses' of 10 mg / day) into 2.5 mg allotments, taken sublingually, twice a day, on a full stomach with a fatty meal, and waited a week before beginning titration of stimulants, to ensure full, stable inhibition of maob.

I dont have any deep knowledge about the general metabolism and life of substances. But the way i understood it, mao inhibition should decrease the threshold dosage of affected drugs. As we all know drugs dont work with all dosages instead we have to come over a certain threshold to feel an effect. If this is wrong then i completely understand why mixing deprenyl with adrenergics would be impossible/hazardous

This sounds right. However, with primarily or even simply highly adrenergic agents, there's a lot of danger of pressing into too high of dosages in terms of adrenergic effects, in search of desirable effects that simply aren't there, or are too muted. My mistake could have been stepping up the propylhexedrine too quickly, but who can know a priori?

ebola