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Combining l-deprenyl with ephedrine?

N

nidhogg

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Oct 14, 2010
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I was planning to take selegiline 5mg ED but i just received a bunch of ephedrine pills. Im wondering if anyone has any experience with this certain combination or with PEA perhaps.

I was considering lowering selegiline dosage to 5mg EOD or E3D to keep a couple of enzymes alive and go with a low dosage of ephedrine for energy.

Would 5mg of eph be a sufficient dose? Will it produce the same effects as a normal non-synergistic(without deprenyl) dose?
 
absolutely do not take any ephedrine.

a bit of PEA is fairly safe. ephedrine is far too adrenergic to risk it.
 
Ephedrine is no good anyway IMO.

At some point I tried it, and also synephrine. I liked the latter better because it was somewhat milder but generally I think the more adrenergic or 5HT2B agonistic (correct?) the more yuck.
 
I will just skip it then although i read someone had great experience with this mix. But better safe than sorry. I have actually never tried ephedrine so i may be overestimating it.

I took my first dose today of 5mg deprenyl and 0.18mg pramipexole. I have only experienced i slight mood boost which might aswell be placebo. Nothing significant. I thought ephedrine might spice things up
 
Mixing selegiline with adrenergic agents is highly risky. Insofar as selegiline 'spices things up', it will be unpleasant and physiologically dangerous.

ebola
 
selegiline + other stimulants = bad news

selegiline's MAOI effects & the fact that its metabolized into l-methamphetamine and l-amphetamine(causes PNS side effects like vasoconstriction, etc,) make it a bad choice to combine with stimulants.
 
Not exactly--if properly titrated, selegiline can selectively inhibit MAOB. Also, because of the usual dosage range, it's very unlikely that catabolism of selegiline produces behaviorally relevant amounts of amp or meth.

ebola
 
Not exactly--if properly titrated, selegiline can selectively inhibit MAOB. Also, because of the usual dosage range, it's very unlikely that catabolism of selegiline produces behaviorally relevant amounts of amp or meth.

ebola
 
ebola? said:
Not exactly--if properly titrated, selegiline can selectively inhibit MAOB. Also, because of the usual dosage range, it's very unlikely that catabolism of selegiline produces behaviorally relevant amounts of amp or meth.

ebola
Click to expand...

even so, its still not a safe combo with ephedrine.
 
it definitely doesn't produce enough l-meth to be an issue at the doses we're talking about.
 
Half of you guys dont seem to know what you are talking about. I thought this was the Advanced Drug Discussion. one liners? come on.
The only reason why combining these is dangerous is because if mao-b is near fully inhibited then you would end up being overrun by epinephrine and norepinephrine. This would cause an unpleasent increase in blood pressure and heart rate, and in some cases even death.

This is why i posted a dose schedule of selegiline, by not going over 10mg/week and with enough mao-b enzymes in my blood stream this would be a matter of dosage.

For example, having 1/4 of your mao-b enzymes inhibited, a dosage of 10mg eph would not differ from having 20mg eph without any inhibition.
 
I suspect that I know what I'm talking about:
http://www.bluelight.ru/vb/showpost.php?p=7659100&postcount=5

I've tried reasonably adrenergic dopaminergic stimulants in combination with selegiline at maob-selective doses, and the potentiation of adrenergic effects from reduced breakdown of the parent chemical was alarming and enduring. I was lucky: I should not have attempted such combinations in the first place.

ebola
 
I was not questioning your expertise ebola?. I was referring to the people who posted before you stating general information that anyone with half a brain already knows. This is after all the 'advanced' drug discussion so oneliners like "lol dis bad stuff" is kind of inappropriate.

Do you mind sharing your deprenyl and adrenergic dosing experience so i can get a little better understanding? Staying in mao-b selective dose doesnt tell much, that just means that you kept your dosage to less than/or 10mg/ED. Then there is the question of in which scale the enzymes have been degraded. There is a huge difference in sensitivity between 5mg/ed and 10mg/EW.
Also which adrenergics did you try? did you try ephedrine specifically? and in which dosage?
 
Hahaha...I was just making a somewhat cheeky joke. Also, I tend to talk in pathologically multi-clause monstrosities, so I've dropped some one-liners in my time. ;)

My regimen was 5 mg selegiline / day (well stablized mao inhibition at that point).
The agent was propylhexedrine, with dosage scaled downward to adjust for potency (125 mg from a usual 250, with moderate stimulant tolerance). The result was increased intensity and doubled duration of adrenergic effects, which felt highly toxic. It was reckless. Never again.

ebola
 
ebola? said:
Not exactly--if properly titrated, selegiline can selectively inhibit MAOB. Also, because of the usual dosage range, it's very unlikely that catabolism of selegiline produces behaviorally relevant amounts of amp or meth.

ebola
Click to expand...

You referring to me? I was merely saying it's a really really stupid idea, not saying that selegiline will mess with his MAO-A.
 
What I meant is that with extremely rigorous procedure, selegiline can be judiciously combined with some stimulants (I have not seen anyone employ sufficiently safe procedure before though, including myself :/). This is not possible with P. Harmala.

ebola
 
ebola? said:
Hahaha...I was just making a somewhat cheeky joke. Also, I tend to talk in pathologically multi-clause monstrosities, so I've dropped some one-liners in my time. ;)

My regimen was 5 mg selegiline / day (well stablized mao inhibition at that point).
The agent was propylhexedrine, with dosage scaled downward to adjust for potency (125 mg from a usual 250, with moderate stimulant tolerance). The result was increased intensity and doubled duration of adrenergic effects, which felt highly toxic. It was reckless. Never again.

ebola
Click to expand...

8o
No wonder why you avoid adrenergics haha
With a stable inhibition of 5mg/ED (which btw is considered overkill by a nootropic fanatic friend of mine) which would cause a huge deplation of mao-b enzymes, a more appropriate dose would be 35mg of propylhexedrine.
The thing about mao-b(and a) inhibition is that sensetivity is exponential to dosage. Say 50% inhibited enzymes does not mean that you can cut synergistic substances in half. This is because there is a large proportion of enzymes that are required for your brain to function normally, so any excess stimulation would cause a huge overrun.

I have zero experience with propylhexedrine but from what i have read from erowid it is a direct vasoconstrictor and more potent than adrenaline when it comes to blood pressure and heart rate. I can only imagine the unpleasant feeling of 125mg on 5mg ED deprenyl

A chart showing how much deprenyl on an empty stomach causes how much inhibition would be nice
 
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