• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Coke and Dopamine Replenishment?

R

rollballs

Bluelighter
Joined
Oct 3, 2001
Messages
226
I have searched and frpm what I have found out coke works on Dopamine in your brain making you feel good. My question is do you have to have all of the wait time in between coke to replinish Dopamine like you have to have the wait time in between E drops to replenishment seratonin. My guess is no because people do coke so much nore frequently by wanted to get your opinion..thanks
 
With all drugs, it's best to wait a few days (or more) before getting high again, for two reasons -- 1)it gives your body time to recover and replenish any necessary neurotransmitters and 2)it helps keep tolerance at bay.
Now, MDMA is special becuase it takes a quite a while (approx. 2 weeks) for your serotonin system to return to normal. The dopamine system, on the other hand, is quite sturdy and recovers much more quickly, usually within days. Thus, you don't have to wait as long before doing dopaminergic drugs (like coke, meth). A few days should be plenty.
 
Or you can try some L-Tyrosine. It is to dopamine what 5htp is to seratonin. Works well for me as a postload (just take one a day for a couple of days after you've been on the drugs)
Harry
 
L-tyrosine is not nearly as effective in replenishing dopamine as 5-htp is in replenishing serotonin...I have experimented with pre and postloading with l-tyrosine and found that it does not do much. As I stated in my previous post, your body makes dopamine quickly just fine on its own so there is little need for supplementation...
 
Originally posted by fairnymph:
The dopamine system, on the other hand, is quite sturdy and recovers much more quickly, usually within days. Thus, you don't have to wait as long before doing dopaminergic drugs (like coke, meth).
Would you like to back this up with some references.
L-tyrosine is not nearly as effective in replenishing dopamine as 5-htp is in replenishing serotonin...I have experimented with pre and postloading with l-tyrosine and found that it does not do much. As I stated in my previous post, your body makes dopamine quickly just fine on its own so there is little need for supplementation...
The reason that L-tyrosine is not as effective as 5-HTP is that under normal conditions tyrosine hydroxylase is maximally active, which implies that the rate of synthesis of the catecholamines is not in any way dependent on the dietary precursor tyrosine. Unlike tyrosine hydroxylase, tryptophan hydroxylase is not usually saturated by its substrate.
Click to expand...
Click to expand...
 
Regarding meth + the dopamine system:
Stefanski R, Lee SH, Yasar S, Cadet JL, Goldberg SR. Lack of persistent changes in the dopaminergic system of rats withdrawn from methamphetamine self-administration. Eur J Pharmacol. 2002 Mar 29;439(1-3):59-68.
Regarding cocaine + the dopamine system:
Administration of cocaine (0.5, 2 and 5 mg/kg) resulted in dose-dependent elevation of dopamine level in the striatal extracellular fluid (ECF) at 0.5 h after injection, and returned to the baseline level within 1.5 h post-injection. At 0.5 post-injection, cocaine reduced dopamine synthesis rate and DAT availability in a dose-dependent manner. The reduction of DAT availability by cocaine (2 mg/kg) returned to baseline level at 3 h post-injection and thereafter. Interestingly, dopamine synthesis rate was significantly higher at 3 h than baseline level and returned to baseline level 5.5 h post-injection.
Tsukada H, Harada N, Nishiyama S, Ohba H, Kakiuchi T. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain Res. 2000 Mar 31;860(1-2):141-8.
Click to expand...
 
Fairnymph, due to lack of time I skimmed thru the abstracts of both articles. It seems that both studies looked just for changes in dopaminergic system. They doesn't compare it with serotonergic system, which would tell the difference in the rate of replenishment between these monoaminergic systems.
 
You must log in or register to reply here.
Top