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Coke AFTER rolling. Stupid?

C

CaramelMind

Greenlighter
Joined
Jul 7, 2012
Messages
15
Hey...

A friend asked me if it would be safe to do some coke after rolling. I guess I'm asking Bluelight for self validation also, but the scenario is... Drop some MD at 12am and roll as normal and then after the GOOD effects have worn off, lets say at about 4am, we do some coke. A line or two to keep the party going for longer. Obviously this is not advised because it is quite ridiculous, I'm asking for experiences I suppose. If I'm being an idiot and this is totally stupid then tell me. I stress again, we do not want to hit the coke whilst feeling good on MD, we want to hit it afterwards.

Merci!
 
VERY stupid. let me give you a lil explanation of how the holes in your brain occur with MDMA:
MDMA = 3,4methylendioxymethamphetamine.
the meth in there releases dopamine.
the methyl prefix releases serotonin.

dopamine is resynthed at a faster rate than sert. so you have all your serotonin dumped into the synapse and the vesicles are still wide open trying to pour out more......the dopamine then backflows in and the result is like when you apply hydrogen peroxide to a cut - oxidization of the neuron = down regulation = fried.

coke releases nothing but dopamine......so you would be having a TON of dopaine back flowing and frying the SERT neurons.

you CAN prevent this by taking an SSRI, e.g. prozac, lexapro, zoloft RIGHT when you start to come down. if you do that, then the coke idea is ok. otherwise FUCK IT.
 
homeydontplaythat said:
VERY stupid. let me give you a lil explanation of how the holes in your brain occur with MDMA:
MDMA = 3,4methylendioxymethamphetamine.
the meth in there releases dopamine.
the methyl prefix releases serotonin.

dopamine is resynthed at a faster rate than sert. so you have all your serotonin dumped into the synapse and the vesicles are still wide open trying to pour out more......the dopamine then backflows in and the result is like when you apply hydrogen peroxide to a cut - oxidization of the neuron = down regulation = fried.

coke releases nothing but dopamine......so you would be having a TON of dopaine back flowing and frying the SERT neurons.

you CAN prevent this by taking an SSRI, e.g. prozac, lexapro, zoloft RIGHT when you start to come down. if you do that, then the coke idea is ok. otherwise FUCK IT.
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mdma doesnt put "holes" in your brain, but it can cause brain damage

coke doesnt release anything, it is a triple reuptake inhibitor (serotonin, dopamine, norepinepherine). it just keeps the neurotransmitters from leaving the synapse

coke after mdma wouldnt be that bad of an idea only because it would be safer than redosing the mdma
 
homeydontplaythat said:
VERY stupid. let me give you a lil explanation of how the holes in your brain occur with MDMA:
MDMA = 3,4methylendioxymethamphetamine.
the meth in there releases dopamine.
the methyl prefix releases serotonin.

dopamine is resynthed at a faster rate than sert. so you have all your serotonin dumped into the synapse and the vesicles are still wide open trying to pour out more......the dopamine then backflows in and the result is like when you apply hydrogen peroxide to a cut - oxidization of the neuron = down regulation = fried.

coke releases nothing but dopamine......so you would be having a TON of dopaine back flowing and frying the SERT neurons.

you CAN prevent this by taking an SSRI, e.g. prozac, lexapro, zoloft RIGHT when you start to come down. if you do that, then the coke idea is ok. otherwise FUCK IT.
Click to expand...

That's... kind of a fail.


For one, the meth doesn't do much of anything, it's the amphetamine that causes dopamine release. Second, the methyl prefix does NOT release serotonin, it causes the molecule to enter the Brain Blood Barrier and reach different receptors of the brain.


Secondly, cocaine doesn't release dopamine... in fact it does the exact opposite. Cocaine is a Dopamine Re-uptake Inhibitor... MDMA is a Dopamine Releaser, among other things.

Since the two have opposite actions at the dopamine terminal, if you combine the two drugs, they actually completely cancel each other out and it's a waste of both




I would recommend against it. Try and get some ketamine instead


you CAN prevent this by taking an SSRI, e.g. prozac, lexapro, zoloft RIGHT when you start to come down. if you do that, then the coke idea is ok. otherwise FUCK IT.
Click to expand...

What the fuck? You want him to do cocaine after taking MDMA and a SSRI that's not prescribed to him? No, just.. no.
 
MDMA = 3,4methylendioxymethamphetamine.
the meth in there releases dopamine.
the methyl prefix releases serotonin.
Click to expand...

This is not true. The words are used to describe the build up of the molecule.

Methyl is a methal group. Its chemistry terminology not a pharmacology action. Pharnacology predictions can be made from certain chemical groups but not a guarantee.

Using the word meth is not correct

http://en.wikipedia.org/wiki/Methyl_group

Both descriptions below mean MDMA. You can break up the relevant terms and mix them around if required. It all means the same thing.

3,4-methylenedioxy-N-methylamphetamine

N-Methyl-3,4-methylenedioxy-A

you CAN prevent this by taking an SSRI, e.g. prozac, lexapro, zoloft RIGHT when you start to come down. if you do that, then the coke idea is ok. otherwise FUCK IT.
Click to expand...

There is some evidence to suggest taking an SSRI into a roll can prevent neurotoxity but I personally wouldnt do it.

I also wouldnt recomend mixing coke with MDMA although I must be honest I did it a lot in my younger more irresponsible days.
 
How is that that possible, given that SSRI's take at least a week to kick in and start to work? You don't and can't just pop an SSRI once to feel better. I would say it would be nothing more than a placebo effect.
 
http://en.wikipedia.org/wiki/Effects_of_MDMA_on_the_human_body

Selective serotonin reuptake inhibitors (SSRIs) have been shown to decrease or block MDMA neurotoxicity in rodents, even if they are given several hours after MDMA. Because of this, some MDMA users administer an SSRI while, or shortly after taking MDMA, in an attempt to prevent possible neurotoxicity. These SSRIs are typically antidepressants such as fluoxetine or sertraline. The theory of some scientists [who?] is that SSRIs prevent dopamine or a neurotoxic MDMA metabolite from entering through the serotonin reuptake transporter, where it is theorized that it may contribute to formation of reactive oxygen species, including hydrogen peroxide.
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If that is true, which I have my doubts (nothing against you, but as your post states, it's just a theory) would'nt taking some 5-htp do just as well?
 
If that is true, which I have my doubts (nothing against you, but as your post states, it's just a theory) would'nt taking some 5-htp do just as well?
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Its not my theory that quote is published in the wiki link given.

5HTP is just a precursor to serotonin metabolization so very different to inhibiting serotonin reuptake

Or does 5-htp have no interactions with dopamine?
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As I understand it no only a precursor to serotonin but the body is a very complex thing and it may influence dopamine in some way I dont know for sure? A neurologist would be a better person to consult. This is quite a complex question to answer.
 
laugh said:
Lots of mixed info here...plenty of opinions zero evidence or proof...just saying
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Maybe do your own research then instead of relying on others to hand you everything on a silver plate? Just saying..


There are plenty of threads on this subject already. MDMA and cocaine cancel each other out when used together. You can use it before and after and get effects, but if you try it while rolling you won't feel shit. It's generally recommended to just avoid it all together.
 
I know. That's why I said, nothing against you bro. I just dont believe that theory to be true.
 
^ It's true. 5-HTP is completely different from an SSRI though, so I don't understand this:

If that is true, which I have my doubts (nothing against you, but as your post states, it's just a theory) would'nt taking some 5-htp do just as well?
Click to expand...




I believe has something to do with shutting off the release of serotonin and starting the recovery process faster.. but that's me talking out of my ass. Overall I wouldn't recommend it, but there have been studies proving it to be true.
 
I was reffering to what was said about it being beneficial to take an SSRI while coming down of your roll.
 
Lots of mixed info here...plenty of opinions zero evidence or proof...just saying
Click to expand...

I was reffering to what was said about it being beneficial to take an SSRI while coming down of your roll.
Click to expand...

Some sources suggest it might work. Others suspect it might not as shown below.

Your not going to find outright evidence or proof as its a very complex topic.

To make an informed choice about if you would want to try it further research would be a must.

It is a plausable theory however.

http://dancesafe.org/drug-information/ecstasy-and-neurotoxicity

Does Prozac prevent MDMA neurotoxicity?

SSRIs (prescription anti-depressant drugs, such as Prozac, Paxil and Zoloft) stick to and block the SERTs. Because of this effect, SSRIs can reduce the ability of the chemical that causes MDMA neurotoxicity (whatever it is) to get inside the axon and cause damage.[15] However, in doing so they also reduce MDMA's ability to work. As a result, people who are on daily doses of SSRIs may be safe from neurotoxicity, but they usually don't feel the normal effects of MDMA either. The idea of using SSRIs to prevent neurotoxicity is something of a catch-22: If you take the SSRI after coming down from the MDMA, it's probably too late to do a lot of good. On the other hand, taking an SSRI before-hand tends to reduce the desired effects of MDMA, making it more logical to simply take less MDMA in the first place. All things considered, it's unlikely that taking an SSRI before or after MDMA is a very useful prevention strategy. Since SSRIs have their own side effects and potential risks, the practice should probably be avoided.
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Oh, I see now. You're right though, I would'nt recommend taking an SSRI after rolling either.
 
Folley said:
Maybe do your own research then instead of relying on others to hand you everything on a silver plate? Just saying..


Yeh I agree with doing your own research, good idea! So I've come to this thread for some info to help with hr same as op and...

I'm not sure about your aggressive/antagonistic silver plate comment, where did that come from, what's the matter?
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