Opioids Codeine: The side effects of it's histamine release

[Anon54]

Is it always a good idea to take an anithistamine expecially with high doses of Codeine or does the actuall side effects of histamine really only create the "itchiness" & no other side effects?

Both of these quotes are from explaining what histamine is & what its side effects are:
http://en.wikipedia.org/wiki/Histamine

Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.[1] Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and other proteins, in order to allow them to engage foreign invaders in the infected tissues.[2] It is found in virtually all animal body cells.

Which histamine receptor(s) does Codeine effect of these 4 quoted below?

The four histamine receptors that have been discovered:
Type Location Function

H1 histamine receptor Found on smooth muscle, endothelium, and central nervous system tissue Causes vasodilation, bronchoconstriction, bronchial smooth muscle contraction, separation of endothelial cells (responsible for hives), and pain and itching due to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness; sleep regulation.

H2 histamine receptor Located on parietal cells Primarily stimulate gastric acid secretion

H3 histamine receptor Found on central nervous system and to a lesser extent peripheral nervous system tissue Decreased neurotransmitter release: histamine, acetylcholine, norepinephrine, serotonin

H4 histamine receptor Found primarily in the basophils and in the bone marrow. It is also found on thymus, small intestine, spleen, and colon. Plays a role in chemotaxis.

I don't usually take an antihistamine with codeine but after reading about histamine on Wikipedia, maybe it would eliminate alot of the side effects.
And, as a bonus, many people clain the sedating Antihistamine can potentiate Codeine or atleast syneergize & give extra sedation.

If u do take an antihistamine, which one do u take and why do u think it's the best?
Just found an old pack of Fexofenadine, don't know if this will do the trick. It's an H1 histamine receptor antogonist which I've noticed pretty much ALL the common antihistamines are a group of so I'm assume Codeine effects the H1 receptor!
http://en.wikipedia.org/wiki/Antihistamine
take a look at the antihistamine like here if ud wish. If u refer to the side effects quoted about from the H1 histamine recptor u, like me may consiter aklways taking an antihistamine with Codeine expecially in the high doses

 

[doppelganga196]

Histamines also cause nausea with opiates in some.

 

[oldkaw]

If you find histamine dump a problem, and w/h high doses of codeine you probably will, benadryl works well. Itch usually is well after dosing, so maybe wait and see if you need it, and compare pre/post use.

 

[phatass]

IME 100mg of hydroxyzine or 100mg of promethazine will prevent the massive histamine release

 

[drug_mentor]

Hey dude, think you may find this thread I made in AusDD helpful http://www.bluelight.ru/vb/showthread.php?t=507954 Unfortunately it has been closed due to a review of codeine discussion in AusDD.

There is a lot more than just antihistamines which may or may not be useful to you depending on how satisfied you are with the current buzz codeine/opiates give you and if you want to push it further.

There is a section devoted to antihistamines, I give my personal opinion on them individually as well as a dose guide. The listed brand named are for Australia, but may be the same in your country of residence. IIRC you post in AusDD anyway, so the brand names are probably relevant. Cheers.