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  • BDD Moderators: Keif’ Richards

codeine potentiate?

jamez

jamez

Greenlighter
Joined
May 17, 2010
Messages
41
Location
UK
Apologies if this has already been covered, but there seem to be so many conflicting reports about what works and what doesn't.

So, what non-pharmacutical substances can one use to potentiate codeine?
What definately works?
 
Grapefruit juice seems to split the crowd - some say it potentiates, others say it detracts from the experience. Personally I might lean on the latter side, although not very noticeably, and I haven't tried it all that often. I'd say test it, and if it works, then good for you, but I think that the very fact that people seem to be undecided about it says something about the degree to which it potentiates it; not remarkable.

Black pepper is a viable way to boost the codeine experience, as well as a small amount of alcohol if you like that sort of thing.
 
Anything with citric acid!
Click to expand...

not true at all, citric acid has nothing to do with grapefruit juices potentiating ability
 
Do remember that codeine's effects are largely due to codeine itself and codeine-glucuronide. Morphine plays a negligible role (except in people with impaired metabolism). So enzyme inhibition really isn't the way to go.

As a codeine addict, I can offer you a couple of solutions:

- A strong antihistamine (in normal doses) such as hydroxyzine and the one that starts with a "p" whose name I can't remember and am too lazt to look up.

- An acid to aid absorption in the stomach, so orange juice works fine.

- Rectal administration (which is my choice of all three).
 
promethazine (which i think is what jamshyd was alluding to) is the best OTC (in the UK anyway not sure about other countries) antihistamine to potentate codeine by a long shot.
 
Inducers are the way to go.

You can drastically boost the amount of morphine to well over 20% of your codeine doses. (the average is 10%)
(Alcohol, phenobarbital, carisoprodol...)

Inhibition does nothing to heighten a codeine high. They hinder the already low amount of morphine that is made by the liver by it, making a cut off on the stronger metabolites. Why care about length when you are not getting high? People who shoot up normally and are fighting withdrawals should say nothing to this as you are accustomed to the shorter periods of high.

Anti-cholinergic (most anti-histamines fall in this as well) drugs are used because of the added pain-killing they add, and will actually dull a codeine high but boost analgesia as most are inhibitors. (Promethazine, Diphenhydramine, hydroxyzine...) Sedation is well confused with nodding as the codeine will cover up any RLS you may get from the anti-histamines. This is where the most confusion I see is coming from.
Anti-histamines kill the "comforter like" warmth of the opiate.

What is stated above does not apply to stronger opiates/opioids that need no conversion to be moderately-highly active.

This is why I say codeine should not be an opiate of choice for anyone but beginners and W/D sufferers.
 
I've now tried a few things that people have suggested in this thread. Thought i'd post my experiences in-case anyone's interested.

Tried the grapefruit juice thing.
Drank 2 large glasses (about a litre), waited 20 minutes, then took my usual cwe brew - approx 300mg. All on an empty stomach.
...did not really notice much of a difference, if any. Was rather disappointed as there seem to be so many reports of this working. I'm no expert on chemical volatility however, so maybe the time that elapsed between ingestion of juice and cwe brew might have something to do with it. Would appreciate some feedback from people that have successfully used grapefruit juice as a potentiator.

Also tried the orange juice thing.
Same process as above, but replaced grapefruit juice with pure orange juice.
Definitely noticed some effects this time. Nothing terribly outrageous, but there was definitely a significant change in the strength of the effects, enough to warrant trying it again.
Again though, i'd appreciate some input with regards to ingestion times, amounts etc..

Then again, the placebo effect is a clever demon, so this could all be in my head. But i'm certain that the OJ strengthened my experience.

Not tried the anti-histamine method yet. Will attempt this later in the week and post results.


And herein endeth the rants of a noob. Lol.
 
Well codeine, like morphine, enjoys better absorption in acidic conditions. That's why OJ showed slight improvement.

The GFJ, although acidic, also inhibits the wrong enzymes, so it is kinda counter productive.

It works the same way that using a base like Tums increases absorption of amphetamines.
 
Tried the anti-histamine method, thought I'd post my results in-case anyone's interested.

Took 100mg Diphenhydramine Hydrochloride, followed by 300mg (cwe) codeine.
About 30-40 minutes later i started to feel the effects of the codeine, as normal. But with the added nuance of the sleeper. I can see now why people confuse the codeine nod with the sedating effect of the sleeper. And although the sensations were not unpleasant, i honestly do not believe that the Diphenhydramine Hydrochloride potentiated the codeine in any way.

It was more like two drug events running at the same time, and sorta cancelling each other out.

I do not think i will be repeating this method.

As far as i can tell, the only method i've tried that holds any obvious merit is the OJ method.
 
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