So in Taiwan I've been struggling to find a decent codeine preparation, this is seemingly the best one I've found after checking like 7 pharmacies. Sorry for not laying it out the best way.
The gist of it is I seem to be able to obtain liquid containing codeine phosphate, chlorpheniramine maleate and maybe dl-methylephedrine hcl (I can't find its solubility) using a cold water extraction. I am deducing this based off the water solubility of each chemical and comparing it to acetaminophen's. How could I go about removing the CPM and methylephedrine? More specifically, the CPM as I imagine it'd be uncomfortable and it would reduce codeine high.
per tablet:
100 mg acetaminophen
83.33 mg ethenzamide
3 mg codeine phosphate
1.25 mg chlorpheniramine maleate
6.67 mg dl-methylephedrine hcl
20 mg caffeine anhydrous
‘safe’ test batch = 17 tablets
1700 mg acetaminophen
1416.61 mg ethenzamide
51 mg codeine phosphate
21.25 mg chlorpheniramine maleate
113.39 mg dl-methylephedrine hcl
340 mg caffeine anhydrous
even if you consumed this w/o extraction should not need hospital? maybe.
desired recreational dose = 34 tablets
3400 mg acetaminophen
2833.22 mg ethenzamide
102 mg codeine phosphate
42.5 mg chlorpheniramine maleate
226.78 mg dl-methylephedrine hcl
680 mg caffeine anhydrous
acetaminophen:
https://en.wikipedia.org/wiki/paracetamol NSAID
solubility in water: 10.97 mg/ml @ 15 c (low)
7.21 mg/ml @ 0 c (low)
https://www.health.harvard.edu/pain/acetaminophen-safety-be-cautious-but-not-afraid
hepatotoxic, daily dose limit: 3000 mg
will be filtered out via cwe
ethenzamide:
https://pubchem.ncbi.nlm.nih.gov/compound/ethenzamide NSAID
solubility in water: <1 mg/ml @ 16 c (very low)
oral ld50 in mice: 700 mg/kg
will be filtered out via cwe
codeine phosphate:
https://pubchem.ncbi.nlm.nih.gov/compound/codeine-phosphate opioid
solubility in water: >= 100 mg/ml @ 16 c (high)
https://psychonautwiki.org/wiki/codeine
threshold: 30 mg
light: 50-100 mg
common: 100-150 mg
strong: 150-200 mg
heavy: 200 mg+
chlorpheniramine maleate:
https://medlineplus.gov/druginfo/meds/a682543.html antihistamine
https://go.drugbank.com/drugs/db01114
https://en.wikipedia.org/wiki/cyp2d6
cyp2d6 enzyme inhibitor: reduces amount of codeine metabolised to morphine
anticholinergic toxidrome, sedation
https://pubchem.ncbi.nlm.nih.gov/compound/chlorpheniramine-maleate
solubility in water: 10-50 mg/ml @ 21 c (moderate-high)
will NOT be filtered out via cwe.
dl-methylephedrine hcl:
https://go.drugbank.com/salts/dbsalt001572 stimulant
dilates bronchi to sedate coughing
may cause decrease in urination, insomnia, headaches, tremor, cardiac arrhythmia (stimulant effects)
predicted solubility in water: 15.4 mg/ml (temp? low but moderate dose-wise)
https://www.chemsrc.com/en/cas/18760-80-0_1189835.html oral ld50 in mice: 758 mg/kg
http://www.ccgh.com.tw/html/drug_list.aspx?pagetype=10&otherkind=R-C001&showid=170 highest single tablet dosage seen: 20 mg
might be filtered out via cwe? ok if some stays anyway.
caffeine anhydrous:
https://pubchem.ncbi.nlm.nih.gov/compound/caffeine stimulant
https://www.amazing-food.com/caffeine-solubility-content-coffee-beans-extraction/
solubility in water: 10 mg/ml @ 15 c (moderate)
6 mg/ml @ 0 c (moderate)
https://psychonautwiki.org/wiki/caffeine
threshold: 10 mg
light: 20-50 mg
common: 50-150 mg
strong: 150-500 mg
heavy: 500 mg+
will be filtered out via cwe. ok if some stays anyway.
The gist of it is I seem to be able to obtain liquid containing codeine phosphate, chlorpheniramine maleate and maybe dl-methylephedrine hcl (I can't find its solubility) using a cold water extraction. I am deducing this based off the water solubility of each chemical and comparing it to acetaminophen's. How could I go about removing the CPM and methylephedrine? More specifically, the CPM as I imagine it'd be uncomfortable and it would reduce codeine high.
per tablet:
100 mg acetaminophen
83.33 mg ethenzamide
3 mg codeine phosphate
1.25 mg chlorpheniramine maleate
6.67 mg dl-methylephedrine hcl
20 mg caffeine anhydrous
‘safe’ test batch = 17 tablets
1700 mg acetaminophen
1416.61 mg ethenzamide
51 mg codeine phosphate
21.25 mg chlorpheniramine maleate
113.39 mg dl-methylephedrine hcl
340 mg caffeine anhydrous
even if you consumed this w/o extraction should not need hospital? maybe.
desired recreational dose = 34 tablets
3400 mg acetaminophen
2833.22 mg ethenzamide
102 mg codeine phosphate
42.5 mg chlorpheniramine maleate
226.78 mg dl-methylephedrine hcl
680 mg caffeine anhydrous
acetaminophen:
https://en.wikipedia.org/wiki/paracetamol NSAID
solubility in water: 10.97 mg/ml @ 15 c (low)
7.21 mg/ml @ 0 c (low)
https://www.health.harvard.edu/pain/acetaminophen-safety-be-cautious-but-not-afraid
hepatotoxic, daily dose limit: 3000 mg
will be filtered out via cwe
ethenzamide:
https://pubchem.ncbi.nlm.nih.gov/compound/ethenzamide NSAID
solubility in water: <1 mg/ml @ 16 c (very low)
oral ld50 in mice: 700 mg/kg
will be filtered out via cwe
codeine phosphate:
https://pubchem.ncbi.nlm.nih.gov/compound/codeine-phosphate opioid
solubility in water: >= 100 mg/ml @ 16 c (high)
https://psychonautwiki.org/wiki/codeine
threshold: 30 mg
light: 50-100 mg
common: 100-150 mg
strong: 150-200 mg
heavy: 200 mg+
chlorpheniramine maleate:
https://medlineplus.gov/druginfo/meds/a682543.html antihistamine
https://go.drugbank.com/drugs/db01114
https://en.wikipedia.org/wiki/cyp2d6
cyp2d6 enzyme inhibitor: reduces amount of codeine metabolised to morphine
anticholinergic toxidrome, sedation
https://pubchem.ncbi.nlm.nih.gov/compound/chlorpheniramine-maleate
solubility in water: 10-50 mg/ml @ 21 c (moderate-high)
will NOT be filtered out via cwe.
dl-methylephedrine hcl:
https://go.drugbank.com/salts/dbsalt001572 stimulant
dilates bronchi to sedate coughing
may cause decrease in urination, insomnia, headaches, tremor, cardiac arrhythmia (stimulant effects)
predicted solubility in water: 15.4 mg/ml (temp? low but moderate dose-wise)
https://www.chemsrc.com/en/cas/18760-80-0_1189835.html oral ld50 in mice: 758 mg/kg
http://www.ccgh.com.tw/html/drug_list.aspx?pagetype=10&otherkind=R-C001&showid=170 highest single tablet dosage seen: 20 mg
might be filtered out via cwe? ok if some stays anyway.
caffeine anhydrous:
https://pubchem.ncbi.nlm.nih.gov/compound/caffeine stimulant
https://www.amazing-food.com/caffeine-solubility-content-coffee-beans-extraction/
solubility in water: 10 mg/ml @ 15 c (moderate)
6 mg/ml @ 0 c (moderate)
https://psychonautwiki.org/wiki/caffeine
threshold: 10 mg
light: 20-50 mg
common: 50-150 mg
strong: 150-500 mg
heavy: 500 mg+
will be filtered out via cwe. ok if some stays anyway.
