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  • AADD Moderators: andyturbo

Codeine Extraction

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I have an old tray of pills called Mersyndol Forte, containing in each drop:

Paracetamol 450g
Codeine Phospate 30mg
Doxylamine Succinate 5mg

Ive done my research and know that the Doxylamine Succinate is also water soluble, so pumping out a CWE with these pills will get me codeine plus this.

Doxylamine Succinate is a hypnotic drug, meaning that it will send you to sleep. According to my findings, the dosage required to send you to sleep can be as low as 6.25mg, but it appears to be safe at least up to 50mg, which can be considered a single dose in pharms running under other names.

This effect may come in handy if after a night out or something i want to get to sleep easier, and it would be cool to have the codeine background to drifting off. Mostly, however, its an undesired effect for me. Im wondering how much drowsy effects you can really get from, say, 20mg of the stuff? Has anyone used much of it? Will the codeine in the solution add to its effect?

Also, the packet is quite old (a couple of years) and im wondering if any of these chemicals "go off" or react badly with each other over time.
 
If you are not used to antihistamines then 20mg of Doxylamine will knock your socks off. 50mg and you won't wake up for 18 hours. I Wouldn't combine more than about 12mg with opiates due to the risk of respiratory depression. Please be careful.
 
If you are not used to antihistamines then 20mg of Doxylamine will knock your socks off. 50mg and you won't wake up for 18 hours. I Wouldn't combine more than about 12mg with opiates due to the risk of respiratory depression. Please be careful.
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I regularly take antihitamines for hayfever, but your advice is definately noted. for codeine ill probably stick to nurofen plus then, and use no more than 1 and a half of these pills anytime i decide to do an extraction for a sleeping elixer. better safe than sorry.
 
Out of curiosity, and I'm sure this has been covered, but how clear do you want yur sokution if using nurofen plus, about 20pills? I can't filter out any more gunk really and the solution is cloudy. I have filtered 4 times, and only really removed solids the first time, a nice ball. Any suggestions?
 
All the codeine extractions I have seen done are always cloudy, but when you hold your glass up to the light you should see no particles floating, if you have filtered it 4 times there is no point filtering any more you are probably just losing more codeine in the filters.
 
willow: I have a feeling the residual cloudiness is just water-soluble binder or perhaps some of the magnesium stearate (which is a tabletting aid) passing through the filter.
Even with professional laboratory filters I haven't been able to get it perfectly clear.
The fact that you've removed a big ball of insolubles suggests that's you've removed the vast majority of what we don't want (fillers, APAP/ibuprofen, etc).
When this is evaporated, redissolved and basified and put in a non-polar solvent there is no observable insolubles sooo, i'd say it's pretty pure eh.

Oh, and clear your damn box! It's, ah, full. Heh :)
 
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using the chemists own codeine/paracetamol tabs, i find that on passing through a coffee filter, there is certainly a degree of cloudyness. against the light, floating particulars are certainly seen, and left to sit for extented periods solids settle to the bottom. also, passing through a 20 micron syringe filter leaves the fluid crystal clear, so the cloudyness is certainly due to undissolved constituents. unfortunately, the micron filters clog up too quickly to be useful for this purpose.

best bet is to minimise the amount of water used, and the water temperature, then you should have a very small amount of paracetamol dissolved in the fluid. this then allows for the largest tolerance for paracetamol fractions which pass through the filter.
 
my extractions are always crystal clear with alot of gunk in my filter. filtered once, using panadeine 8mg codeine/500mg APAP tablets. Chemists Own work alright too
 
I'm really concerned with people who talk about 'cloudy solutions'.

Easiest way to do a decent extraction that is clear.

- grab two coffee filters.

- scrunch one up into a ball and wet it. Put it at the bottom of your funnel, the tube part.

- Wet another coffee filter and put in funnel as normal.

- Pour solution into funnel.

Solution will come through clear.

I think I might make a movie. Die Slow: Codeine Extraction ;)
 
I think I might make a movie. Die Slow: Codeine Extraction
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Lol.

Yeah, I thought it was commonly accepted around here though that the cloudiness is the result of the binders and fillers used in the tablets. As long as there aren't any obvious solids in your solution, you should be fine...that's my understanding of it.
 
If you're really that concerned, let the cloudiness settle, collect it up, dry and weigh. If it's less than a dose of APAP or ibuprofen - then you're obviously all sweet. As i say though, I haven't observed isolateable cloudiness.
 
i certainly found it with chemists own brand paracetamol/codeine. passed it through a coffee filter a number of times. on letting some of it settle (takes a few hours), it appears to only be a very small amount, most probably less than 500mg.

how long does it usually take to pass the solution through a filter? i find it starts well, but then becomes very slow as the filter clogs up.
 
johnnyonelove said:
how long does it usually take to pass the solution through a filter? i find it starts well, but then becomes very slow as the filter clogs up.
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That can be frustrating. What I have done in the past is wet a small tea towel or something similiar and put it over a bowl. I then pour the solution into the tea towel in the middle, and twist either end. Just squeeze it and squeeze it into the bowl until there is no more moisture left in the tea towel. When you open it up you will have a big, dry clump of paracetamol. Repeat the process a few times to get as much codeine as possible. This will save you time, however you might lose some of your yield of codeine doing it this way(?). You will be left with a cloudy solution, but one that will filter quite quickly and be practically clear after you filter it through coffee filters/kitchen towel.

Sorry if I didnt explain that very well. I've just had an extra long lunchbreak at the pub.

Hope it helps at least.
 
MattPsy said:
Mr Blonde:
Eat the desloratadine & St. John's Wort at T-2hrs.
Start drinking the wine and grapefruit juice (or maybe make up a weak vodka + grapefruit juice mixer, if you prefer) at T-1hr.
Drink down your codeine solution using grapefruit juice as a chaser, maybe a little more alcohol (but very very sure not to have too much!). I have anywhere between 300 and 450mg. This is T=0.
Smoke your joint at T+1hr. This is when the codeine is peaking. You'll be pretty fucked at this point. Lie down, relax, and watch a good movie.
:)
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Just thought I'd recommend this to anyone who enjoys their codeine. I tried this combo last week, hit me harder then codeine has ever done before! Thank again to MattPsy for providing the timetable :)
 
Ummm, what is desloratadine and how does it work in potentiating codeine? Is it available OTC in Aus?

And what's the mode of action of St John's Wort? As far as I understand, it acts as a CYP3A4 inducer (see http://en.wikipedia.org/wiki/CYP3A4#CYP3A4_ligands) so theoretically it should increase the amount of codeine that gets metabolised in norcodeine (inactive) thus reducing the effect of codeine. Therefore, how is it possible that St John's Wort potentiates codeine?

Nevertheless, if I can get my hands on some Claramax I will give this a go because I am very curious. If it doesn't work it'll prove to be an expensive exercise in futility.
 
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Tortoise: desloratadine is metabolised by CYP3A4, which means it acts as substrate. Imagine your CYP3A4 enzymes as little pacman-type creatures. They eat molecules of certain types.
For the purposes of this explanation they are living in a fish tank. Now you pour a mixture of desloratadine and morphine molecules into the tank. The pacman-fish go to work muching up the substrates. The purpose of adding the desloratadine is so that while the enzyme is busy munching it up, it's not eating a morphine molecule instead.

A pharmacologist would call this compeditive substrate.

The end effect is to make the destruction of morphine take longer, so you're wasted for a longer period of time :) .

And it doubles as an antihistamine, so you get less itchy. Neat huh.

St. John's Wort is both a CYP2D6 inducer and a CYP3A4 inducer. It's a pity that it induces CYP3A4, but nothing we can do about that :( . I believe the CYP2D6-mediated positive effects (higher proportion of codeine -> morphine) to outweight the negatives of the CYP3A4 induction (faster destruction of the produced morphine).

Mr Blonde: I'm pleased you enjoyed it :) !
 
Cool. Thanks for the response. You answered my question perfectly!

I have just been doing some research and have discovered that echinacea is a CYP3A inhibitor and i will experiment to see if this potentiates codeine. If so, it could be used instead of grapefruit juice. I'll post my results soon.
 
Cool man, I look forward to them :) . echinacea huh... cool. I might have to try that myself!
 
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