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  • BDD Moderators: Keif’ Richards | negrogesic

Codeine Dosage?

lightitup

Bluelighter
Joined
Jan 16, 2006
Messages
423
Location
Terrapin Station
My friend gave me some codeine pills(Tylenol 3) and I have never tried it so I had a quick question. I looked around and saw the equivalency charts say about 10mg Codeine= 1mg Oxycodone. Of course I will be cold water extracting to take out all of the APAP.

So I figured I would take around 300-350mg of codeine, since it takes me about 30-35mg of oxycodone to nod. Then I remembered reading something about a maximum dose of codeine. I thought it was around 350, but i couldn't remember.

So my question is, will it be pleasurable/safe to take 350mg of codeine if 30-35mg of oxycodone is my usual dose?
 
There really isn't a ceiling dose, this idea is perpetuated by the belief that any effects you get from the codeine are due to Morphine conversion, which is not true. Morphine plays a negligible role in Codeine with normal metabolism.

It is a good idea to start low and work your way up. At some point, the histamine effects of codeine can get too irritating for you to get anything out of it.
 
350mg should be very pleasurable for your first time (if it is), but remember to take a strong anti-histamine like Doxylamine 30-40 minutes before you dose or you might be scratching your face off all night.
 
So it turns out I only have 210mg. I should have grabbed more but my buddy ate them all before I got back ha.

I'm questioning what to do about it. Let my tolerance drop for a long time, and then do it? Potentiate it and hope for the best?
 
Doxylamine is an anti-histamine and also a potentiator of Codeine. Take 40mg and the 210mg Codeine, but MAKE SURE you do a Cold Water Extraction before taking them because you could cause liver failure with 3500mg APAP at once.
 
210mg should definitely be safe especially if you are oxycodone-tolerant, I took 330mg codeine with no recent tolerance as well as some hydroxyzine and was fine.
 
I did 262 today with a slight tolerance - wasn't "euphoric" as such, but incredibly sedating, relaxing, and mood lifting. So 300+ would have you set ;)
 
There really isn't a ceiling dose, this idea is perpetuated by the belief that any effects you get from the codeine are due to Morphine conversion, which is not true. Morphine plays a negligible role in Codeine with normal metabolism.

Can you clarify what the active metabolites are?
 
Codeine in and of itself is active as an agonist at opioid receptors, albeit with smaller affinity than stronger opiates. It's main metabolites are norcodeine (slightly less active), Codeine-3-Glucuronide (not active AFAIK) and Codeine-6-Glucuronide (most active). There is a small quantity of Morphine and its respective Glucuronide metabolites. Wikipedia claims a tiny portion of Hydromorphone, but I have yet to see any sources for it.
 
Apparently codeine is metabolized by UGT2B7 to odeine-6-Glucuronide. UGT2B7 is induced by TBHQ (in the range of 40 to 80 micrograms). Does this mean eating prepared foods containing TBHQ might have an effect on codeine's metabolism or is this taking it too far.
 
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