Codeine+CYP3A4inhibitor+CYP2D6inducer

[Bludda]

I have a question:

With Codeine, you want a CYP2D6 inducer and a CYP3A4 inhibitor.

Most CYP2D6 inducers (what you want) are also CYP3A4 inducers (what you do not want...).
These substances don't potentiate Codeine?

I can only assume that it will be a much of a muchness..... More codeine will be converted during it's first pass around your body, whereas more morphine will be eliminated on it's first pass. I suppose it would depend on how fast one's metabolism is...... but IMHO it would seem that inducing both these enzymes would produce a shorter, but more intense experience...

So, yes, the codeine will be potentiated.....but you'll be getting rid of it (as morphine) quicker and more effectively.

PS:

Peoples, be careful playing with carbamazepine - and any other antipsychotic/anticonvulsant/sedative that is an antihistamine (such as mirtazepine and dermazepine). These drugs are generally prescribed to knock out fairly intense mental disorders. They are not without some pretty crazy sideeffects. Apart from knocking you completely out, they play pretty serious games with your brain chemistry.

I've have had two friends who have been taken off carbamazepine because both of them, at one point during their respective treatments, went completely fucking nuts (ie. flipped out and went became insanely aggressive for a short period). These antihistamines have been known to aggravate hitherto unknown mental disorders, causes amnesia and extreme agression.

If you still want to take it as a potentiator, know that a single 200mg pill will put you on your ass. I would recommend taking a quater with any amount of codeine at the most.

Maybe there are other safer anti-histamines out there that will poteniate codeine?


Respect and Peace

 

[Survival0200]

EDIT: rubbish

 

[Bludda]

I dunno if anyone read the bottom of my first post (second post in this thread - i can understand why, it's too damn long).........BUT..........

Carbamazepine and Alcohol will both have the same effect as far as inducing both enzymes........ You will be making more morphine while at the same time you will be clearing more morphine.

**Carbamazepine + grapefruit juice will have the same effect on your enzymes as Alcohol + grapefruit juice (as far as codeine is concerned).**

The only difference is CARBAMAZEPINE WILL FUCKEN KNOCK YOU OUT - you have a much greater chance of getting into serious trouble with the carbamazepine and grapefruit, then you would the alcohol and grapefruit.

I repeat once more: Carbamazepine + GP juice will effect the exact same enzymes as Alcohol + GP juice. Still it doesn't matter - read my first post....You don't need to combine anything with the grapefruit juice


Respect and Peace

 

[Eduard]

CYP2D6 inducers will make more Codeine converted to Morphine.
CYP3A4 inhibitors will let the Mophinr stay longer in the system.

Is there big differences between different persons on these things? I mean, could take much over 400mgs and feeling that the effects get better (ie. not getting much or relatively any of unpleasant histamine effects) with larger doses. And it's really hard to get as strong effects of bube than of codeine. Isn't it strange?