Does anyone notice increased effectiveness of a mix of codeine and hydrocodone??I seem to enjoy a better high mixing the two than taking them separately....
Opioids in general can potentiate each other when taken concomitantly leading to increased effects, though care needs to be taken with dosage so you don’t take too much.
Im not certain and haven’t specifically taken those two together but there could also be some enzyme mediated potentiation between them also