codeine and loratadine?

[caizar]

will taking the anti-histamine loratadine or even certrizine lessen the high you get from taking a high amount of codeine ??

 

[Tchort]

It's possible, but I doubt it. I am not sure off the top of my head which CYP450 enzyme it is a substrate of, but I don't think it is metabolized by the same one(s) as Codeine.

It should make you more comfortable by reducing or eliminating the Histamine related side effects, plus it doesn't cause drowsiness.

 

[monstanoodle]

Just makes sure you take it after the effects of the Codeine have started to take place, that way there's no possibility of it interfering with your enzymes at the wrong time.

 

[Xtc <3]

Did 380mg of codeine last night with 10mg of loratadin.
Took the loratadin about half hour before the codeine.
The high was great and less itching involved :D

 

[Jimshoe]

I was under the impression that anti-histamines could potentiate the effects of opiates. I have heard of taking diphenhydramine before opiates to intensify the effects and reduce itching.

 

[Levvytation]

There's conflicting advice about potentiating codeine on this forum, because unlike most other opiates its a 'pro drug',. meaning it has to me metabolised via the liver into morphine.

Some here say take GFJ before your codeine...some say take it after
because it blocks the livers conversion into morph. The same goes with other opiate potentiators such as promethazine, cemitedine etc.

Personally I go with the grape fruit before the codeine, & (on the rare occasion I use it, promethazine/tagemat etc) after the codeine has kicked in. This method seems to work for me, but perhaps it varies from person to person..

8)What you won't get on this forum is a DEFINATE/CERTAIN answer to this....its probably the most contentious issue here. lol