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  • BDD Moderators: Keif’ Richards | negrogesic

Codeine and Loperamide (Potentiation/Synergy)

M

mysticbeef

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Joined
Feb 16, 2011
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The Killer with a thousand faces has got me in his
Hey guys,

Just wondering if I wanted to use some loperamide to enhance my codeine high, when should I take the loperamide? 30 mins before dosing the codeine?

Would anything be gained by taking the loperamide after the codeine? I've already had my codeine for today but I'm guessing you need the loperamide to saturate the enzyme BEFORE the codeine is metabolized.

Also, what dose of loperamide should I aim for? My codeine dose is ~384mg (My tolerance is high from ~2 years of using cd but I still do feel the effects, new users should aim for a much lower dose, I don't even get itchy from this dose at all whilst intolerant users may hit anaphalaxsys .

Namaste,
mysticbeef
 
mysticbeef said:
Hey guys,

Just wondering if I wanted to use some loperamide to enhance my codeine high, when should I take the loperamide? 30 mins before dosing the codeine?

Would anything be gained by taking the loperamide after the codeine? I've already had my codeine for today but I'm guessing you need the loperamide to saturate the enzyme BEFORE the codeine is metabolized.

Also, what dose of loperamide should I aim for? My codeine dose is ~384mg (My tolerance is high from ~2 years of using cd but I still do feel the effects, new users should aim for a much lower dose, I don't even get itchy from this dose at all whilst intolerant users may hit anaphalaxsys .

Namaste,
mysticbeef
Click to expand...

Considering we had a Codeine talk last night or whenever (lost my memory i think on that) im scared as hell to do it. I myself wont ever mix it with anything unless I know 100% sure its okay unlike my my mistake when i thought i could do anything and be safe because i dont ever OD. I think since you have opioid/opiate tolerance you may be fine. I just read this, i dont know 100% if its legit but i usually took that for my stomach issues from using the bathroom a lot because of having my galbladder removed. heres what i read online:

Loperamide is an opioid-receptor agonist and acts on the opioid receptors in the myenteric reflex of the large intestine; by itself it does not affect the CNS. It works similarly tomorphine, by decreasing the activity of the myenteric plexus, which in turn decreases the tone of the longitudinal and circular smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

That is very new to me! ^^^^^^ I don't know if it helped but you helped me learn something so thanks! If I didn't provide you with anything that helped im sorry i tried bud! I will keep researching!

Also since i did 300mg of codeine with xanax which was dumb, i think if i did codeine (300mg) alone with loperamide i would consider taking maybe 2-4mg and if all goes well maybe just increase the dose very little at a time, then next time you may have a perfect match!
 
I don't think loperamide will potentiate codeine at all, loperamide predominatntly has non-central effects. So it will potentiate your constipation but not much else.
 
Product said:
Considering we had a Codeine talk last night or whenever (lost my memory i think on that) im scared as hell to do it...

That is very new to me! ^^^^^^ I don't know if it helped but you helped me learn something so thanks! If I didn't provide you with anything that helped im sorry i tried bud! I will keep researching!

Also since i did 300mg of codeine with xanax which was dumb, i think if i did codeine (300mg) alone with loperamide i would consider taking maybe 2-4mg and if all goes well maybe just increase the dose very little at a time, then next time you may have a perfect match!
Click to expand...

I can understand why, from your experiences, you are very weary of codeine.

I'm glad this discussion enabled you to gain some new knowledge!


sekio said:
I don't think loperamide will potentiate codeine at all, loperamide predominatntly has non-central effects. So it will potentiate your constipation but not much else.
Click to expand...


That's what I originally thought but there's quite a few anecdotal reports online of it doing some sort of potentiation. Thought they of course can be taken with a grain of salt because they are after-all online and subjective. In the end any effects could just be placebo. I certainly can't find any peer reviewed double-blind trials relating to the matter.

The one theory I found that seemed somewhat logical was that by saturating opiate receptor sites in the body meaning more of the codeine reaches the brain. I don't know if this is true though because they might be different receptor sub-types.

I guess all I can do is try some lope beforehand next time and see what happens. - Once I do this I'll be sure to let people know.

Thanks.
Namaste,
mysticbeef
 
It's definitely more relaxing, sort of like the space between sleep and awake, not quite a nod but nice nonetheless. I could just float around in this cloud all day. I think the loperamide has done something, not a lot, but something.

Hopefully next time I'll have more than 2mg of lope to mess around with.

Don't try this at home.

Namaste,
mysticbeef
 
Okay about 10 minutes after drinking down the codeine and all I can say is WOW. This is incredible, rushes of euphoric energy but a sense of calm at the same time. Relaxed alertness. It crept on a little bit, then hit - bam. I'll keep my eye on the time as it goes on to see what effects happen when, and edit it below.

TIMELINE
-HH:MM
-00:00 Loperamide 6x2mg = 12mg
-00:45 Codeine CWE ~30x12.8mg ~384mg (~ because of the extraction process)
-00:55 Starting to feel different
-01:00 Rush come on really strong and intense, lovely
-01:05 Rush subsiding, still feel relaxed though
-01:10 Pretty much a general stoned feeling, not really nodding off but pleasant intoxication
-02:30 Effects diminished by now, still there and relaxed but less intense (50% )
-03:00 Effects further diminished (30% )


Overall I would say it increased the rush by 25%-40%, and the general stoned feeling by 10%-20%.

Something to keep in mind though is that this was on the same day as my 2mg trial earlier that day. I would imagine a 24+ hour washout period would yield better and more reliable results.

more to be added.
 
Last edited:
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