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Cocaine Cocaine vasoconstriction and agmatine or citrulline for vasodilation

It will help a bit on the peripheral circulation, but since Cocaine is a calcium channel blocker, it wont work like it would with amphetamines. That is also why Cocaine is so dangerous to the heart. Any way, the best tips I can give you is: do less.
Call it a night after the sixth line or so. Then you wont be so bothered by vasoconstriction. And most of the good effects are diminished any way, leaving you only twacked out with a nasty stim feeling and wide awake.
 
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Yes….I get 116 gram bottle of L-Citrilline powder from Healthy Planet

L-Citrilline is Amazing for healthy BP & cardiovascular health. Nitric Oxide a potent vasodilator I use for sex purposes in a cocktail with LSD or Cannabis, 200mg depo-testosterone IM several days before weekend

1.5 gram X 3 daily and 2 - 3 hours before I take a fat scope

L-Arginine 1,000mg tablets are almost useless before of metabolism

L-Citrilline 5g daily is a significantly more effective L-Arginine which increases Nitric Oxide in the bloodstream giving ROCK HARD erections lol and you won’t get a heart attach sweating like a maniac in a 45min-1h cluster fuck on LSD ha ha

But ya…..Cocaine use…..would be great to be taking L-Citrilline 1.5g X 3 daily & Taurine 1,000mg X 3 daily (taken together)

Magnesium Bisglycinate 200mg few hours prior to bed is also advisable
 
someguyontheinternet said:
Has anyone tried to combat the vasoconstriction of cocaine with vasodilators like citrulline or agmatine? Would this help with some of the cardiac side effects?
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I've been having great success using agmatine to counteract the vasoconstriction from kratom and tobacco.

Kratom vasoconstriction is so bad for me that I wake up with terrible headaches and weird visual disturbances, like it's cutting off blood flow from my brain's occipital region. Tobacco gives me day time headaches.

I've been taking 500mg agmatine in the morning/evening, and these issues have stopped. It also has significantly lowered my blood pressure and improved circulation, I no longer get cold feet.

Great stuff!
 
Snafu in the Void said:
I've been having great success using agmatine to counteract the vasoconstriction from kratom and tobacco.

Kratom vasoconstriction is so bad for me that I wake up with terrible headaches and weird visual disturbances, like it's cutting off blood flow from my brain's occipital region. Tobacco gives me day time headaches.

I've been taking 500mg agmatine in the morning/evening, and these issues have stopped. It also has significantly lowered my blood pressure and improved circulation, I no longer get cold feet.

Great stuff!
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Kratom causes vasoconstriction for you? I don't think I've noticed any 😮
 
someguyontheinternet said:
Do you get it with both leaf and extract?
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Yes, both. My body seems like it's starting to reject mitragynine in general. In the last year or so it's been giving me various other side effects that I have not had in the 9 years prior. Anxiety/dehydration/liver issues/palpitations, etc.

I assume it's mitragynine because both leaf and extracts do it, but 7-OH doesn't cause these issues.
 
Even things like controlling your breathing in through the nose and out the mouth creates vasodilation via nitric oxide, vitamin c and supplements that help with nitric oxide production.
Breath of Fire Technique

Your inhale and exhale time is equal, with no pause in between breath. You should have two to three cycles of breathing in and out per second once you master breath of fire. When you inhale, your abdominal muscles relax and allow oxygen into your lungs, as if automatically”

I also take L-Citrulline helps with nitric oxide depletion. Also take propranolol and spironolactone both are very easy to get prescribed as they’re non narcotic and together are great vasodilators.(i have acne-spiro/i have anxiety-prop) I also take .25mg clonazepam.

Biggest thing overall is limiting your sessions to set amount- not giving into the need to reup after. The vasoconstriction effects last hours as compared to you high so you’re increasingly compounding high blood pressure and low oxygen, which is not great.
 
someguyontheinternet said:
Has anyone tried to combat the vasoconstriction of cocaine with vasodilators like citrulline or agmatine? Would this help with some of the cardiac side effects?
Click to expand...
I have been on a bit of a coke binge over the last couple of weeks and the headaches are getting to a level that is very nearly ruining it for me.

I thought they were being caused by dehydration and or going long periods without eating properly, however after being vigilant in addressing both of these issues, yesterday I was still hit with a nasty headache, they come like clockwork a few hours after my last bump.

I enjoy lifting weights, something that has become very sporadic lately due to me currently enjoying the coke more, but that is neither here nor there.

However because of my other hobby of lifting I happen to have a non stimulant pre-workout supplement handy, this particular one has 10 grams of L-citrulline, 2 grams of L-taurine, 2.5 grams of betaine and 1 gram of agmatine sulfate per serve, so should be an effective formula to combat the vaso constrictive effect of the cocaine.

I will be trying this today and will report back on whether it allows me to avoid the headach that has become a unwanted side effect.
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@someguyontheinternet, I gave this a try yesterday and it totally workde.

So I made sure I ate pretty well during the day and kept well hydrated, however I had tried that numerous times and still got a cracker of a headache a few hours after my last bump.

Yesterday I still ate pretty welll and drank water, the only difference was I made a drink with the pre-workout I mentioned and consumed it just after my last bump and I never even got a trace of headache.

Ok this was my first experiment but it sure looks promising.
 
Agmatine works well as it's an alpha-2 adrenergic agonist. This action directly counteracts cocaine induced vasoconstriction.
It's also great at reducing tolerance build-up and drug potentiation. I wrote about this here.

Another potent vasodilator is nicotinic acid aka vitamin B3 (hence the flush rection).
Here's a big list I found. Obviously the harmalas are MAOIs so be careful what you combine them with.

Vasodilators
Achillea millefolium (Yarrow)
Alcohol (wine, beer, etc.)
Amoracia rusticana (Horseradish)
Banisteriopsis caapi (contains harmine, harmaline, tetrahydroharmine)
Berberis vulgaris (Barberry)
Black cohosh (Cimicifuga racemosa)
Cocao (contains theobromine)
Cocoa (contains theobromine)
Coleus forskholii (Coleus)
Coptis spp. (Goldenthread)
Chocolate (contains theobromine)
Cinnamon
Eleutherococcus senticosus (Siberian ginseng)
Garlic (Allium sativum)
Ginger (Zingiber officinale)
Ginkgo biloba
Harmaline
Harmine
Hawthorn
Huperzine
Kola nut (contains theobromine)
L-Arginine
Melissa offiicnalis (Lemon Balm)
Olea europaea (Olive leaf)
Peganum harmala (contains harmine, harmaline, tetrahydroharmine)
Panax ginseng (Chinese Ginseng)
Passiflora incarnata (AKA Passionflower, contains mostly harman, and a little harmaline, harmalol and harmine)
Petroselinum crispum (Parsley)
Rauwolfia serpentina (Indian Snakeroot)
Scutellaria baicalensis (Baical Skullcap)
Tetrahydrocannabinol (THC)
Tetrahydroharmine
Theobromine
Tilia europaea (Linden Flower)
Trigonella foenum-graecum (Fenugreek)
Urtica dioica (Nettles)
Valeriana officinalis (Valerian)
Veratrum viride (American Hellebore)
Viburnum spp. (Cramp, Bark, Black Haw)
Vincamine
Vinpocetine
Viscum album (European Mistletoe)
Vitamin B3 (niacin)
Xanthoxylum americanum (Prickly Ash)
 
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