Cocaine Use Possibly Potentiates MDMA?

[G_Chem]

Stumbled upon an interesting article that talks about how self administered cocaine use increased SERT expression. They even speculate at one point how cocaine could possibly negate MDMA serotonin toxicity or at least the noticeable decrease in SERT availability when the two drugs are co-administered together. Makes me want some cocaine even more

Effects of Cocaine and MDMA Self-Administration on Serotonin Transporter Availability in Monkeys - Neuropsychopharmacology

Although serotonin (5-HT) can interact with dopamine (DA) systems to modulate the subjective and reinforcing effects of psychostimulants such as cocaine and 3,4-methyldioxymethamphetamine (MDMA, ecstasy), the long-term effects of exposure to psychostimulants on brain 5-HT systems are not well...

www.nature.com

-GC

 

[Darksidesam]

you have to remember though that it is more stress on the cardiovascular system and could pose a health risk to those whose heart may not be quite up to scratch and also increases a risk of overdose from either side (MDMA or Cocaine) , not for the inexperienced or the faint hearted

 

[G_Chem]

Oh definitely not recommending I’ve had/have? a cocaine addiction and it can get nasty. Strange drug where I can use it semi responsibly so long as I don’t have it in my possession. I haven’t touched it in 2yrs and been jonesing for a sniff but even though I’ve been offered quite a few times I wait until I can buy a gram to myself then have a good few days.

Thought the research was interesting. My first roll was probably extra strong as I was addicted to cocaine then, along with them being very potent MDA/MDMA mixes it had me in a different world.

-GC

 

[simstim]

I just bought cocaine for the first time in like a year tonight.

 

[G_Chem]

I just bought cocaine for the first time in like a year tonight.

Lets hang.. I kid I kid.. lol.

I’ll actually be getting some most likely myself here soon, I’ll be in the area for it so hopefully I get myself a tasty gram.

Tell me how it is. My hearts racing now thinking about how that first line will be when I finally get it. 2yr break will probably have me flying.

-GC

 

[simstim]

It's crack that I bought. I've been doing bumps of fentadope all evening planning to go after seven pm for some meth.

I walked all the way there and the guy still hadn't reupped so I bought crack. He said he'd have meth again in the morning.

Crack+fentadope is a better high to me than fentadope plus meth. Classic speedball. Just too expensive. I'm not one to chase crack. That's way too expensive for someone like me.

So relaxing feeling, though. I'm melting into the couch.