4DQSAR
Bluelighter
- Joined
- Feb 3, 2025
- Messages
- 6,080
Latin American organised crime ‘may operate in 16 European countries’
Cocaine seizures in Europe are up more than fivefold in 10 years as a host of cartels take root. A four-month Guardian investigation reveals the true scale of a continent-wide shift
I've been watching it happen in the UK.
From the invention of the £5 'crack deal' to people running through tens of thousands of pounds a month.
It seems unlike most opioid users who can at least fall back on methadone, because there is no current substitution therapy, people with a cocaine problem are far less likely to go to a local HR unit (Aspire usually) and ask for help.
FYI it's just my opinion that while researchers pay with Ritalin as a possible substitute, amfonelic acid exists as does the even more active homologue in which that pendent benzyl moiety is swapped for a phenyl ether. Now I wouldn't like to guess but I would be VERY tempted to add a para fluoro to that pendent aromatic as it sits in the same lipophilic pocket as cocaine BUT if the para doesn't work then the meta. But in either case it metobolically hardens the product.
I don't think substitution therapy is a good thing in the long term but if the result is a medication where one oral dose lasts for 12+ hours then at least it means users aren't redosing in a compulsive manner.
