Well that's just not true. The "best" bump is the first, but they're all good. Unless your supply sucks.No matter the ROA, the only good bump is the first bump. All you really need to know about cocaine.
Late 80s. Good supply.Well that's just not true. The "best" bump is the first, but they're all good. Unless your supply sucks.
Generally speaking, a releaser and a reuptake inhibitor at the same time can be unpleasant. There's such a thing as dopamine overload where the side effects just get uncomfortable.My theory is: if cocaine just blocks dopamine re uptake, would it not be a good idea to do something else that gives you a dopamine rush at the same time??
That way more dopamine would be around (say an orgasms) while the re-up take system is out of order.
Eye think it's called a speedballMy theory is: if cocaine just blocks dopamine re uptake, would it not be a good idea to do something else that gives you a dopamine rush at the same time??
That way more dopamine would be around (say an orgasms) while the re-up take system is out of order.
Isn't a speedball heroin + cocaine? This will give you loads of dopamine for sure, yeah. Never came to do an actual speedball yet. Just a herbal one if this counts, Kratom and Coca leaves.Eye think it's called a speedball
Traditional speedball is heroin and coke iv. Now it's any opi and any stim with any route of administration.....Isn't a speedball heroin + cocaine? This will give you loads of dopamine for sure, yeah. Never came to do an actual speedball yet. Just a herbal one if this counts, Kratom and Coca leaves.
Agree, or Holland, Spain..Late 80s. Good supply.
I got hooked on hero through speedballs. Thought I was invincible, but no.Isn't a speedball heroin + cocaine? This will give you loads of dopamine for sure, yeah. Never came to do an actual speedball yet. Just a herbal one if this counts, Kratom and Coca leaves.
The Analogy between Cocaine, a dual re-uptake inhibitor. DRI/ NRI and SRIMy theory is: if cocaine just blocks dopamine re uptake, would it not be a good idea to do something else that gives you a dopamine rush at the same time??
That way more dopamine would be around (say an orgasms) while the re-up take system is out of order.
Coke and methylphenidate are inverse agonists at the transporters, causing them to dump their targets instead of sucking them up. That's why cocaine has such pronounced acute effects and a SSRI doesn't. Because with a plain transporter antagonist autoreceptors immediately downregulate release of the target molecule and inverse agonists circumvent this mich like releasers but they result in a different firing pattern.The Analogy between Cocaine, a dual re-uptake inhibitor. DRI/ NRI and SRI
Vs. the inferior pharmaceutical version MethylPhenidate, which totally lacks Serotenergic action. And imo is plain crap. Coke is already bad enough.
Can you explain how comes Cocaine nullifies a MDMA high. Which afaik is a triple releaser and inhibitor.Cocaine and MPH are inverse agonists at the transporters
Can you explain how comes Cocaine nullifies a MDMA high. Which afaik is a triple releaser and inhibitor.
Same for an SSRI, on a SSRI forget MDMA while Coke and MPH will work.