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Cocaine before MDMA?

Jackie Chan

Jackie Chan

Bluelighter
Joined
Nov 16, 2010
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181
I came across this article, not sure if it's been posted or discussed here before:

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00522.x/abstract

Repeated cocaine treatment followed by withdrawal protected against MDMA-induced dopaminergic neurotoxicity by internalizing DAT via a mechanism which may involve PKC. Furthermore, repeated cocaine followed by withdrawal induced behavioural and neurochemical sensitization to MDMA, measures which could be indicative of increased rewarding effects of MDMA.
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It's suggesting that doing coke before mdma might prevent some neurotoxicity and increase the euphoric effects of mdma. Has anyone ever done coke and then during the comedown taken mdma? How did this affect their roll?

I like crack and mdma, but haven't done either in a while. I was thinking a morning smoking some crack and then afternoon rolling might make for a fun day. Has anyone ever tried something like this?
 
Smoke crack, decrease neurotoxicity, increase euphoria. I don't think so. If anything coming off cocaine will make your roll weaker.
 
I don't think doing coke on the comedown from MDMA is good idea. If anything, the comedown will be worse once you run out coke.
 
It's not as simple as you think, but yea it has been said the less dopamine you have in your brain before mdma means less damage from mdma. But that doesn't mean you go out and get crack and cocaine and do it before rolling to reduce damage, won't work like that.
 
FIRST POST WOOT! Saw this thread and god damnt it was destiny...

Well, I must say its been a fateful evening for myself. And I honestly joined, because my experience today brought me here. Good to see such a cool community. Ive been around ex a long time, just never really take it that often. Sometimes, its the whimsical craving which finds me in mdma land...but I must say I cant help but feel like the stars were shining on me tonight (super lame, I know). I only grab molly, not that I cant get pills, butIm the sort of consumer that doesnt mind paying, and would prefer quality over repetitive use of mediocre product. I like to have indulge very rarely with MDMA, but when I do, I make sure Im gonna have a fantastic time. But enough jabbering. I understand that my experience is not the universal answer or support for the article, but Id say there is probably something to it. Here's how my day went today:

10AM-11AM - insufflated 1.5 gram cocaine. GOOD STUFF. Rode the coke coaster. 11AM- 4PM - smoked about 2 grams of cannabis. 1 99C Arizona Sweet Tea

By this time, the coke had completely wore off, and honestly I just felt really baked.

5 PM - Popped 150 MG MOLLY Gel Capsule ... This is where it got strange, and I could tell something was up... I kept waiting for it to hit me, all I had ingested was the coke, cannabis, and the sweet tea. 2 whole hours pass, and I aint feeling shit...At this moment thoughts crossed my mind, did I get fucked here on this? I KNEW it was good stuff. The taste, the source...

7 PM - Figured it was something up, ill tell you when I say I didnt feel anything, I didnt feel anything. No rush, no precursors, no sweat. I just felt high from the cannabis. So, I parachuted another 150...

830 PM - Im starting to feel a bit rushy. I can feel a bit more energy. But still for the most part, I know something is still different. Its been a good 3 and a half hours, and this shit hadnt hit me...

9 PM - GOD DAMNT. Im floatin, chillin, and feeling fanfuckingtastic.

So ive wasted enough time typing lol...it seems to do something good. A delay, unlike Ive ever experienced...but explosively euphoric. Id say the come down off the cocaine, aided in something. Just my conveniently timed adventure of the night. Ill try and let you know how long it lasts...I still have a 700 mg's left, and a lot of time and music to enjoy. Molly <3 .

EDIT: forgot to mention this is the FIRST time, ive ever mixed the two substances.
 
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Cocaine will BLOCK the MDMA from entering your neurons and working its magic -- DON'T DO IT!

It is a reuptake inhibitor which blocks the transporters that MDMA uses to get into DA/NE/5HT neurons. The MDMA probably hit you that late because that's when the cocaine was leaving the brain--it has a very short half-life.
 
Yeah, mixing coke and MDMA is a bad idea. Chances are pretty high that the coke will negatively impact your roll, as AJ45 noticed.
 
k-opioid said:
Cocaine will BLOCK the MDMA from entering your neurons and working its magic -- DON'T DO IT!

It is a reuptake inhibitor which blocks the transporters that MDMA uses to get into DA/NE/5HT neurons. The MDMA probably hit you that late because that's when the cocaine was leaving the brain--it has a very short half-life.
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I would definitely not advise ingesting cocaine, simultaneously with MDMA. However, at the time of MDMA ingestion, it had nearly been 6 hours after cocaine. Im telling you the only unpleasant thing I experienced was the delay. But once it kicked it, the roll lasted the same length and felt like a completely normal roll.

levictus said:
Yeah, mixing coke and MDMA is a bad idea. Chances are pretty high that the coke will negatively impact your roll, as AJ45 noticed.
Click to expand...

I'll reiterate, the effects Im sure are subjective to the individual (tolerance, body chemistry, purity of drugs, etc), but from what I did yesterday, I couldn't really call ita "negative" effect. It just was delayed. Its now been approx 14 hours since the last dose, I feel normal. Im a bit tired, and a little foggy, but this has probably been one of the easiest comedown Ive ever experienced. Again, I wouldnt suggest that cocaine+mdma is a great thing for everyone, and as some have pointed out here, it actually blocks the effects of mdma... It just happened to work for me.
 
I would say once you start coming down a tad...if you want to prolong the party...then start in with the coke.
 
Saying that it helps the MDMA affect the brain is kind of strange. Maybe if you are using Vyvanse or Adderal as prodrugs, but I don't cocaine will have the same affect.
 
Renz Envy said:
Smoke crack, decrease neurotoxicity, increase euphoria. I don't think so. If anything coming off cocaine will make your roll weaker.
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I agree. After we ran out of blow (about half a gram per person) we immediately took some rolls. Didn't roll very hard. This was back in the early nineties when the rolls were generally reliable.
 
Jackie Chan said:
I came across this article, not sure if it's been posted or discussed here before:

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00522.x/abstract


It's suggesting that doing coke before mdma might prevent some neurotoxicity and increase the euphoric effects of mdma. Has anyone ever done coke and then during the comedown taken mdma? How did this affect their roll?

I like crack and mdma, but haven't done either in a while. I was thinking a morning smoking some crack and then afternoon rolling might make for a fun day. Has anyone ever tried something like this?
Click to expand...



Recently me and a couple of friends snorted about 2 grams each of white and afterwards we had some pokes left over from like 2 weeks before. Well i downed 2 and some my friends took 2 or 1 but gotta say i barely even felt anything i was too gone off the yay and too numb that it pretty much ruined the effects of the mdma, but one time i was coming down off some mollys and snorted like a gram of the finest scales you could find in the city and it definetly help me come down off the rolls but i couldnt fall asleep but i took some doxylamine succinate and that solved the problem.
 
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