Does anyone have any word on the interaction of these, the SSRI combination thread said that SSRI's and coke can be combined safely. But i read other wise on another thread, i think both of these drugs are an inhibitor of this certain enzyme so it can make the coke much stronger. If zoloft (sertraline) inhibits dopamine which i think it does mildly, would it be dangerous to do coke which also inhibits the re uptake of dopamine? I would really like this cleared up, anyone with experience or knowledge on this subject
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OD Moderators: Keif’ Richards | negrogesic
Cocaine Cocaine and Zoloft mixture
- Thread starter F1n1shed
- Start date
I think Sentraline raises the QT interval, so does coke. It could cause a fatal arrhythmia called tosades de pointes(french for twisted points). This might have been what killed Anna Nichole Smith's son Daniel, who was taking methadone, which also raises the QT interval, with sentraline and lexepro.
I have mixed coke with the similar celexa, and am fine. It didn't seem any different, but procede with cation.
I have mixed coke with the similar celexa, and am fine. It didn't seem any different, but procede with cation.
sekio
Bluelight Crew
Simple answer: don't.
Vaya
Bluelight Crew
sekio
Bluelight Crew
Combining two serotonin reuptake inhibitors is not a smart idea. There are far too many pharmacological factors to consider when you go about abusing reuptake inhibitors all willy-nilly, especially when there may be concurrent chronic treatment with e.g. a SSRI or SNRI. Chronic SSRI treatment in particular is known to greatly alter the functioning of many serotonergic drugs.
For the uneducated, cocaine is not only a dopamine reuptake inhibitor, it is also a serotonin-norepinephrine reputake inhibitor too. It has a great effect on all three monoamine pathways and isn't exactly a "clean" drug. On top of the reuptake inhibition is a sodium channel block responsible for numbing and also for messing with cardiac currents. There are other as of yet uncharted receptors it binds to, I'm sure, but those are the major ones. My point being: only the dopamine (and to a lesser extent, norepinephrine) reuptake inhibition is sought out in a psychostimulant, usually. Elevated serotonin levels are certainly part of the cocaine experience but they are not on their own pleasurable.
In the best case the cocaine will only be mildly potentiated (because of the SSRI), but some aspects of it could be dulled entirely if there is a strong SNRI working, which will instead stop cocoaine from binding to the transporters to work its magic. There's also the whole QT interval elongation to conisder as mentioned above, probably due to the sodium-channel effects of cocaine - cocaine & other local anesthetics like lidocaine are known for playing havoc with heart rythyms if not carefully prescribed and monitored.
If you want to play it safe, don't combine cocaine and antidepressants! You shouldn't be doing blow if you're on antidepressants anyway! How do you think you're gonna feel on the tail end of your cokeout?
In the end my advice is basically: if you're going to do cocaine, make sure you've got a clean system. Don't run the risk of a heart attack for some lines of bloe and a 20 minute high. If you want a stimulant then get some amphetamine or (m)ethylphenidate, (even caffeine), geeez. And if you wanna feel real good, spend your money on MDMA, 2c-*, DOx or LSD instead. Coca is not a happy plant to be investing in at the moment, what with the nonsense in Mexico and the whole dewormer scandal.
For the uneducated, cocaine is not only a dopamine reuptake inhibitor, it is also a serotonin-norepinephrine reputake inhibitor too. It has a great effect on all three monoamine pathways and isn't exactly a "clean" drug. On top of the reuptake inhibition is a sodium channel block responsible for numbing and also for messing with cardiac currents. There are other as of yet uncharted receptors it binds to, I'm sure, but those are the major ones. My point being: only the dopamine (and to a lesser extent, norepinephrine) reuptake inhibition is sought out in a psychostimulant, usually. Elevated serotonin levels are certainly part of the cocaine experience but they are not on their own pleasurable.
In the best case the cocaine will only be mildly potentiated (because of the SSRI), but some aspects of it could be dulled entirely if there is a strong SNRI working, which will instead stop cocoaine from binding to the transporters to work its magic. There's also the whole QT interval elongation to conisder as mentioned above, probably due to the sodium-channel effects of cocaine - cocaine & other local anesthetics like lidocaine are known for playing havoc with heart rythyms if not carefully prescribed and monitored.
If you want to play it safe, don't combine cocaine and antidepressants! You shouldn't be doing blow if you're on antidepressants anyway! How do you think you're gonna feel on the tail end of your cokeout?
In the end my advice is basically: if you're going to do cocaine, make sure you've got a clean system. Don't run the risk of a heart attack for some lines of bloe and a 20 minute high. If you want a stimulant then get some amphetamine or (m)ethylphenidate, (even caffeine), geeez. And if you wanna feel real good, spend your money on MDMA, 2c-*, DOx or LSD instead. Coca is not a happy plant to be investing in at the moment, what with the nonsense in Mexico and the whole dewormer scandal.
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I already ended up doing some tonight, it was definitely a small amount and i took a half xanax bar to keep me calm. This stuff seems to be relatively uncut to be honest, i didn't feel ampy on it but that could just be the xanax. Thanks for the input, I was just going off the mega thread which said SSRI's and coke should not have any interactions and is safe. I actually don't feel any comedown, people reported SSRI's make for a more mellow come down. Could it be a factor that i took the zoloft in the morning around 12 pm and did the blow around 12 hours after with the xanax. I also know that coke works mildly on serotonin and mostly on dopamine re uptake, and my SSRI works mainly on serotonin and very mildy on dopamine re up take. It's not regular use, i am just seeing if it is okay to do small lines while still on the SSRI. I will not make a normal habit, because it will not help the medication.
Vaya
Bluelight Crew
sekio said:
This is the part I was hoping someone would have expanded on. Appreciate your taking the time to write out that response sekio.
~ vaya
These also raise the QT interval, same risks as coke. It's not necessarely related to local anesthetic effects.This list(http://www.azcert.org/medical-pros/drug-lists/printable-drug-list.cfm) claims these upper are only a risk with congenital QT prolongation, but in theory there still might be a risk in combination with other drugs.sekio said:
In all likelihood your serotonin levels are already much higher even though the anti-depressant effects haven't set in yet.I felt SSRI right away, though it didn't do shit for my depression. But serotonin syndrome isn't the risk, QT prolongation is. Nothing will probably happen, but you should be aware of the risks.f1n1shed said:
I see , well im always careful and don't do retard sized lines. The QT prolongation makes sense and the new SSRI's don't affect QT as much as the old ones, unless your dosing high. Thanks though, i had some left over which is why i was asking. Ill make sure to go slow and steady 