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Misc Clonidine to reduce adrenergic side effects of stimulants

Juicewrldfan said:
I really want to drink a c4 energy drink but likely not a great idea. Sto it has l tyrosine and it will wake me the fuck up. I’m guessing it’s too risky tho co Sri g the amount I’m on
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Yes, please avoid the energy drink at all costs.
I don’t think there’s anything wrong with you, stimulants make certain people very impulsive and that’s even more likely if your aim is to get really high using stimulants. i’m sure you’ll be okay, just don’t take any more stimulants and try not to panic. i’m sure people have taken much more than you have and been okay. just make sure to try and avoid stimulants for at least a few weeks or months if you can, it will give your brain chance to recover it’s neurotransmitter levels.
 
Juicewrldfan said:
Thought I was coming out of it but no stupid should hurt
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My mind is so foggy like I have abused stims before tho not happy I did, but in more large doses and they never caused break. Fight like this. I literally think I’m about to fall out at times but very briefly then the feeling goes away

I’m guessing anxiety or blood pressure but hard to say. But very hothersome. Can’t explain it quite.
 
Okay I woke
Myself up after falling asleep which sucks because I think I’ll feel better after sleep like someone else said. Right now I’m scattered. So scattered. But I think they are coming back together

I am a little nervous tho because obviously so I fell asleep but it was out of no where and then I woke right away. It’s like I fell into such a deep sleep so quickly I got scared and woke up. Damn it now I’m scared to ho to sleep and if there’s anything needed right now it is sleep. Have you ever experienced this before
 
Juicewrldfan said:
Okay I woke
Myself up after falling asleep which sucks because I think I’ll feel better after sleep like someone else said. Right now I’m scattered. So scattered. But I think they are coming back together

I am a little nervous tho because obviously so I fell asleep but it was out of no where and then I woke right away. It’s like I fell into such a deep sleep so quickly I got scared and woke up. Damn it now I’m scared to ho to sleep and if there’s anything needed right now it is sleep. Have you ever experienced this before
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K it was just sleep. I was out the last half hour or so which is a good thing actually.
 
Hey @Juicewrldfan I'll open by saying that the energy drink is probably a very bad choice. When our brains are not pre-exposed to powerful stimulants like Amphetamine, Caffeine can be both physically and mentally energizing. After being on a long stimulant binge, the only thing Caffeine is gonna do is make your heart palpitations worse and exacerbate general tension.

I am a major proponent of Clonidine (Catapres) and I don't mean just in this situation here. When your choice for sedation is either Diphenhydramine (Benadryl) or Alprazolam (Xanax) it's pretty nice to have this little nugget as some middle ground. Clonidine's pharmacology could be explained simply as a tension-reducing agent; now this is in a physical sense, though this feeling of lesssening tension in the chest tends to feed back into the psychological, convincing a person that they are chill.

Regarding your dosage, given Clonidine's relatively safe nature, I would advise you to experiment and figure out what makes you feel the most okay.

I take 70mg Lisdexamfetamine (Vyvanse) per day, this equates to approximately 40mg Dextroamphetamine; for you "Adderall" folks, it's' basically like taking 50mg Mixed Salts. For my mind, it's perfect. Now for my body, sometimes I can get restless, twitchy etc.

For this daily dose of my stimulant, it's totally normal for me to take 0.2mg Clonidine. It's the perfect balance for myself. So for you, someone who has been binging, it wouldn't be crazy at all to suggest 0.3mg Clonidine and if you're actually trying to sleep 0.5mg Clonidine is not outrageous. Clonidine is a pretty safe drug. but don't get me wrong, if you take too much, your blood pressure will drop low enough to cause hypotensive crisis.

My advice for right now,. do not exceed 0.5mg for any reason unless you really feel like you get how the drug effects you.
 
Keif' Richards said:
Hey @Juicewrldfan I'll open by saying that the energy drink is probably a very bad choice. When our brains are not pre-exposed to powerful stimulants like Amphetamine, Caffeine can be both physically and mentally energizing. After being on a long stimulant binge, the only thing Caffeine is gonna do is make your heart palpitations worse and exacerbate general tension.

I am a major proponent of Clonidine (Catapres) and I don't mean just in this situation here. When your choice for sedation is either Diphenhydramine (Benadryl) or Alprazolam (Xanax) it's pretty nice to have this little nugget as some middle ground. Clonidine's pharmacology could be explained simply as a tension-reducing agent; now this is in a physical sense, though this feeling of lesssening tension in the chest tends to feed back into the psychological, convincing a person that they are chill.

Regarding your dosage, given Clonidine's relatively safe nature, I would advise you to experiment and figure out what makes you feel the most okay.

I take 70mg Lisdexamfetamine (Vyvanse) per day, this equates to approximately 40mg Dextroamphetamine; for you "Adderall" folks, it's' basically like taking 50mg Mixed Salts. For my mind, it's perfect. Now for my body, sometimes I can get restless, twitchy etc.

For this daily dose of my stimulant, it's totally normal for me to take 0.2mg Clonidine. It's the perfect balance for myself. So for you, someone who has been binging, it wouldn't be crazy at all to suggest 0.3mg Clonidine and if you're actually trying to sleep 0.5mg Clonidine is not outrageous. Clonidine is a pretty safe drug. but don't get me wrong, if you take too much, your blood pressure will drop low enough to cause hypotensive crisis.

My advice for right now,. do not exceed 0.5mg for any reason unless you really feel like you get how the drug effects you.
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Yeah I took a couple quarter doses of .2mg pills thru the day after reading your comment earlier and it did help. Now I’m ready to crash lol seriously fall asleep and I fall instantly into deep sleep kinda scared me at first it was so quick and so deep
 
Juicewrldfan said:
Hey ya all….sorry I haven’t been myself these latest posts.

I’m feeling much better now and just wanted everyone to know. I was staring into the abyss for a minute there tho. I’m good now.
Hate stims. So bad for me.
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Glad to hear that. We all make mistakes, but try to reflect on this experience to, hopefully avoid repeating it.
 
Diazepam 10mg
Alprazolam 0.5mg
Pregabalin 150mg
Clonidine 0.1mg

Ultimate anxiolytic cocktai. Tablets pulverized into powder, dissolved in 1.oz of warm/hot water, add orange juice to mask bitter taste ……30-45min onset creeping in / 1h in full effect.
 
Dextro .45 said:
Diazepam 10mg
Alprazolam 0.5mg
Pregabalin 150mg
Clonidine 0.1mg

Ultimate anxiolytic cocktai. Tablets pulverized into powder, dissolved in 1.oz of warm/hot water, add orange juice to mask bitter taste ……30-45min onset creeping in / 1h in full effect.
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All you need is 30mg Methamphetamine thrown into the mix and you have a blockbuster drug of the 1960's ;)

I'm not surprised that cocktail is effective buddy. It ticks all of the boxes with a little Pregabalin to give it some character.
 
Ya….for a euphoric Brompton Cocktail, a dopaminergic stimulant is absolutely essential….but for an anxiolytic strictly no.

in fact….I would add Oxycodone 5-7.5mg (opioid naive) Oxy-IR 5mg scored tablets (no excipients).….and very low dose Ketamine.

Diazepam 10mg - the ultimate anxiolytic with Potent muscle relaxation properties
Alprazolam 0.5mg - rapid acting anxiolytic with prominent antidepressants properties
Pregabalin 150mg - effective anxiolytic with mood-boosting properties
Clonidine 0.1mg - VERY robust anxiolytic properties, lowering BP & HR (half a scored tablet sufficient)
Oxy-IR 5mg - VERY Euphoric non-sedating, stimulating Opioid (opioids are the most effective compounds with anxiolytic & euphoric properties due to endorphins (euphoria) & dopaminergic (euphoria)


Ritalin IR 5mg - Methyphenidate (Ritalin) is a VERY Euphoric Dopaminergic stimulant 3-4X more DAT over NET, has little to no negative effects on increasing HR or BP and safe enough for small children. 0.25mg / per kg of body weight ED-50 required dose to inhibit 50% of DAT - dose required to induce euphoria

Ritalin 60mg IR is well enough to induce euphoria within an hour

Desoxyn (d-Methamphetamine) 5mg tablets are of coarse the most euphoric dopaminergic stimulant on earth, especially IV injection of pharmaceutical METHEDRINE 20 or 30mg ampoules

Preludin (Phenmetrazine) is apparently even more euphoric & pleasurable than IV injected d-Methamphetamine
 
@Dextro .45 that is a pretty gnarly cocktail. I'm not saying it doesn't work for you. For a lot of other people though, this kind of combination is asking for trouble. It's not a good idea for anyone to take this combination without extensive knowledge of the drugs in question and their own reaction to these drugs. As combinations get larger, the effects become more and more difficult to predict.
 
Keif' Richards said:
@Dextro .45 that is a pretty gnarly cocktail. I'm not saying it doesn't work for you. For a lot of other people though, this kind of combination is asking for trouble. It's not a good idea for anyone to take this combination without extensive knowledge of the drugs in question and their own reaction to these drugs. As combinations get larger, the effects become more and more difficult to predict.
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I certainly agree. I’ve never been a supporter of poly drug use, especially when large combinations of substances are involved. I must admit, I’ve never done drugs. aside from caffeine and nicotine, but from what I understand, people either mix drugs too get a stronger euphoria/high or to offset negative side effects of a particular drug. I totally get why people do it, but i’m almost always certain it is going to lead to some serious problems down the line.
My opinion doesn’t apply specifically to recreational drugs. The same goes for psychiatric drugs. when reading online, I come across so many stories of doctors throwing combinations of different antipsychotics and antidepressants, sometimes throwing in an benzodiazepine, mood stabiliser and perhaps a gabapentinoid, all in an attempt to manage depression. unfortunately, the actual reason the combination grew so big likely because the doctor was trying to either potentiate one drug because it wasn’t working, or to manage the side effects of another drug which were becoming intolerable. The sad reality is, many such patients end up much worse than they were previously, describing a feeling of constantly being fried, confused and even more depressed. that’s not to say combinations don’t work, sometimes they can be necessary and life-saving in psychiatry, and for recreational uses they can make for an amazing time.
My advice for combinations is as follows:
Try to avoid them ant all circumstances unless necessary.
Consider the pharmacological actions of each single drug and be very careful if they are able to potentiate each other. if they do, be sure to keep doses of each drug much lower. also keep in mind that drugs which potentiate each other. Will almost certainly do so in the realms of side effects and toxicity. suppose one is using amphetamine to get high or even for a productive boost. it could be that everything is going well until they decide to ingest some caffeine which they assume is a mild stimulant that could help boost the amphetamine euphoria. they could be correct, but they may be unaware that caffeine actually has a completely different mechanism which is going to very strongly boost the adrenergic effects as well as general glutamate release. this is likely going to provoke serious anxiety and increase neurotoxicity risk as well as immediate risks of potentially lethal cardiovascular complications. their experience could easily turn dysphoric due to the anxiety. Had they just stuck to the amphetamine, even taking a little more if they really needed it, they would likely have been much better off.
 
Bomb319 said:
Do you mind explaining how this occurs? I'm currently taking 0.8 mg Clonidine per day/night mostly for sleep and to help prevent withdrawal as I am a fast methadone metabolizer. I'm on 220 mg methadone per day. Is that combination causing less dopamine release for me?
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Holy shit how do you stay awake on that dose. I had to quit taking .2mg in the morning because I’d fall asleep at my desk.
 
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