05-06-201010:48
My actual point in this specific post about sleep was to answer his question about (REM)sleep........
The most important thing is to give the poster of this thread the most information of what I think.
I did not do the best job of explaining so This is more detail....
so he can better understand How reducing a choline decifiency can help your REM sleep.
ACh-the most important inducer of REM sleep because it effects your biological clock...let me break it all down......
with out summing anything up, So that everyone can understand exactly what I am trying to interpret from my brain.
Choline is a very important nutrient...
Choline- compound that is used by the body to synthesize(bind) acetylcholine(neurotransmitter)
Acetylcholine--is a chemical compound meaning- (more than one compound makes up this neurotrasmitter.)
Acetylcholine if the number one neurotransmitter in all autonomic ganglia.
(ACh<--I will use the abbr. for acetylcholine b/c the word to long to keep writing it LOL)
Choline-one of two components of ACh, very important for the nervous system function.
Second component of ACh is ester of acetic acid.
By the way Chloragenic means related to the neurotransmitter acetylcholine.
Anyways..... ACh is made when combining ester of acetic acid and choline.
But just to make this a little more complicated (PA I know this makes you happy) I will go into more detail....
FIrst we need Thioester to happen (combining ester of acetic acid with coenzyme a = acetyl-CoA (acetyl+coenzyme A)
Thioester means combining an organic acid with a enzyme....
Then in the process acetic acid has a proton taken away resulting in = acetate
choline acetyltransferase(organic enzyme) joins together the acetate and choline.
((((Ok Now wahhh Bamm neurotransmitter "acetylcholine(ACh)" is made.))))
ACh- functions- peripheral nervous system (ANS,SNS..etc..)
ACh is a "major" neurotransmitter in the autonomic nervous system.
ACh-has an important role in the enhancement of sensory perceptions<--Important! (for REM, attention, anything regulated by your internal clock AKA autonomic nervous system.....
Sensory perceptions....Are controled by your Autonomic Nervous System
QUOTED from somewhere-->Damage to the cholinergic (acetylcholine-producing) system in the brain is related to memory deficits.
Quote from WIKI-Acetylcholine is the preganglionic neurotransmitter for both divisions of the ANS, as well
as the postganglionic neurotransmitter of parasympathetic neurons. Nerves that release acetylcholine are said to be cholinergic.
In the parasympathetic system, ganglionic neurons use acetylcholine as a neurotransmitter, to stimulate muscarinic receptors.
http://en.wikipedia.org/wiki/Autonomic_nervous_system
(reason for my Dysautonomia (autonomic nervous system disorder.. comment in my other post)
Also plays a part in the central nervous system as a (neuromodulator).
neuromodulator- process where your neurotransmitters regulate neurons. Neurons-AKA-nerve cell) regulate by releasing chemicals (chemicals with a job)
ACh uses its """cholinergic system""" to enhance the excitatory/inhibitory(arousal and reward) responses of the receptors in the NS.
ACh receptors= Protiens that are a stuck together to help with binding of the ACh neurotransmitter.
"""Cholinergic system" is the use of the acetylcholine receptors. Those receptors are there because of the ACh neurotransmitter..derived from Choline....
ACh receptors(AChR)- nicotinic acetylcholine receptors (nAChR)
(this is the recceptor that is inhibited by PCP which causes damage a little research and i answer my own question but..
it would have been really really nice if someone had just posted it..also It can be reversed...I explained that somewhere already)
Anyways the other major AChR is muscarinic acetylcholine receptors (mAChR)..
BOth of thoughs receptors are the main kinds of cholinergic receptors.(again..cholinergic means part of ACh neurotransmitter)
ACh as a neuromodulator(using its cholinergic system) for arousal and reward in the nervous system.^--remember enhances the response of receptors.
(Why would the fda still make manufactures of baby formula add choline?)
So now with me helping out and being more detailed.....
The reason I feel a deficiency of the nutrient Choline is because )))with out it non of this can happen...Also.......
If you do not have enough Choline or you have damaged a receptor made from Choline.........
Your autonomic clock (autonomic nervous system)--that is controled by your ACh neurotransmitter....Will not work properly which I feel and
research, studies, MD journals.....all show that this could be a major problem with a whole lot of people....And would be one of the major
neurotransmitters affecting REM sleep........................
Can you imagine what is going on with the people with this problem....
))))A dysfunction so small somewhere,somehow in your PNS/CNS((....especially if your problem is caused by voluntary drug use.....
PA Now do I make enough sense for you to understand? I know someone will think this is a specific to make my point........
I have to add-- choline supplement that can cross the BBB- Acetyl-L-carnitine
My actual point in this specific post about sleep was to answer his question about (REM)sleep........
The most important thing is to give the poster of this thread the most information of what I think.
I did not do the best job of explaining so This is more detail....
so he can better understand How reducing a choline decifiency can help your REM sleep.
ACh-the most important inducer of REM sleep because it effects your biological clock...let me break it all down......
with out summing anything up, So that everyone can understand exactly what I am trying to interpret from my brain.
Choline is a very important nutrient...
Choline- compound that is used by the body to synthesize(bind) acetylcholine(neurotransmitter)
Acetylcholine--is a chemical compound meaning- (more than one compound makes up this neurotrasmitter.)
Acetylcholine if the number one neurotransmitter in all autonomic ganglia.
(ACh<--I will use the abbr. for acetylcholine b/c the word to long to keep writing it LOL)
Choline-one of two components of ACh, very important for the nervous system function.
Second component of ACh is ester of acetic acid.
By the way Chloragenic means related to the neurotransmitter acetylcholine.
Anyways..... ACh is made when combining ester of acetic acid and choline.
But just to make this a little more complicated (PA I know this makes you happy) I will go into more detail....
FIrst we need Thioester to happen (combining ester of acetic acid with coenzyme a = acetyl-CoA (acetyl+coenzyme A)
Thioester means combining an organic acid with a enzyme....
Then in the process acetic acid has a proton taken away resulting in = acetate
choline acetyltransferase(organic enzyme) joins together the acetate and choline.
((((Ok Now wahhh Bamm neurotransmitter "acetylcholine(ACh)" is made.))))
ACh- functions- peripheral nervous system (ANS,SNS..etc..)
ACh is a "major" neurotransmitter in the autonomic nervous system.
ACh-has an important role in the enhancement of sensory perceptions<--Important! (for REM, attention, anything regulated by your internal clock AKA autonomic nervous system.....
Sensory perceptions....Are controled by your Autonomic Nervous System
QUOTED from somewhere-->Damage to the cholinergic (acetylcholine-producing) system in the brain is related to memory deficits.
Quote from WIKI-Acetylcholine is the preganglionic neurotransmitter for both divisions of the ANS, as well
as the postganglionic neurotransmitter of parasympathetic neurons. Nerves that release acetylcholine are said to be cholinergic.
In the parasympathetic system, ganglionic neurons use acetylcholine as a neurotransmitter, to stimulate muscarinic receptors.
http://en.wikipedia.org/wiki/Autonomic_nervous_system
(reason for my Dysautonomia (autonomic nervous system disorder.. comment in my other post)
Also plays a part in the central nervous system as a (neuromodulator).
neuromodulator- process where your neurotransmitters regulate neurons. Neurons-AKA-nerve cell) regulate by releasing chemicals (chemicals with a job)
ACh uses its """cholinergic system""" to enhance the excitatory/inhibitory(arousal and reward) responses of the receptors in the NS.
ACh receptors= Protiens that are a stuck together to help with binding of the ACh neurotransmitter.
"""Cholinergic system" is the use of the acetylcholine receptors. Those receptors are there because of the ACh neurotransmitter..derived from Choline....
ACh receptors(AChR)- nicotinic acetylcholine receptors (nAChR)
(this is the recceptor that is inhibited by PCP which causes damage a little research and i answer my own question but..
it would have been really really nice if someone had just posted it..also It can be reversed...I explained that somewhere already)
Anyways the other major AChR is muscarinic acetylcholine receptors (mAChR)..
BOth of thoughs receptors are the main kinds of cholinergic receptors.(again..cholinergic means part of ACh neurotransmitter)
ACh as a neuromodulator(using its cholinergic system) for arousal and reward in the nervous system.^--remember enhances the response of receptors.
(Why would the fda still make manufactures of baby formula add choline?)
So now with me helping out and being more detailed.....
The reason I feel a deficiency of the nutrient Choline is because )))with out it non of this can happen...Also.......
If you do not have enough Choline or you have damaged a receptor made from Choline.........
Your autonomic clock (autonomic nervous system)--that is controled by your ACh neurotransmitter....Will not work properly which I feel and
research, studies, MD journals.....all show that this could be a major problem with a whole lot of people....And would be one of the major
neurotransmitters affecting REM sleep........................
Can you imagine what is going on with the people with this problem....
))))A dysfunction so small somewhere,somehow in your PNS/CNS((....especially if your problem is caused by voluntary drug use.....
PA Now do I make enough sense for you to understand? I know someone will think this is a specific to make my point........
I have to add-- choline supplement that can cross the BBB- Acetyl-L-carnitine
