http://www.painstudy.ru/wcp/non_opioid.htm
Aim of Investigation
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Ketamine has been used orally for controlling pain Since ketamine is usually available in injectable liquid forms and tastes very bitter, it shall be too difficult for patients to handle Then we have made chocolate-flavored ketamine (Ketamine Chocolate) tablets
Methods
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1) Preparation of Ketamine Chocolate tablets 50g of chocolate is melted in a microwave oven, 20ml ofketaral50* (1 gram ofketamme, Park Davice Co, Ltd ) is added, heat it again until it becomes pasty Then, the thick paste is equally divided into 64 pieces, each of which is formed to a small tablet, containing approx 15mg ketamine 2) A double-blind test using Ketamine Chocolate tablets and placebo chocolate tablets in CRPS patients 3) A clinical comparative study between Ketamine Chocolate tablet and small dose im ketamine, in 33 pain patients with PHN, HZ or cancer pain
Results
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1) The taste ofKetamine Chocolate tablets is acceptable They are administered orally with no prbolem 2) Ketamme Chocolate tablets were found effective to relieve pain in 12/13cases, whereas the placebo tablets were in 5/12 (p<0 01)3) Sub-lingual ketamine Chocolate tablets decreased VAS from 43 4± 19 1 to 20 8± 14 1 (p<0 01), and 5mg ofim ketamine decreased from 42 9± 15 8 to 170±14 1(p<001) No significant difference was found between both
Conclusions Our Ketamine Chocolate tablet has high patient's compliance and yet powerful pain relief as much as that of 5mg of ketamine mtra-muscular administration They shall be beneficial to many patients who suffer from intolerable pain such as of CRPS, PHN, HZ and cancer.
Aim of Investigation
--------------------
Ketamine has been used orally for controlling pain Since ketamine is usually available in injectable liquid forms and tastes very bitter, it shall be too difficult for patients to handle Then we have made chocolate-flavored ketamine (Ketamine Chocolate) tablets
Methods
-------
1) Preparation of Ketamine Chocolate tablets 50g of chocolate is melted in a microwave oven, 20ml ofketaral50* (1 gram ofketamme, Park Davice Co, Ltd ) is added, heat it again until it becomes pasty Then, the thick paste is equally divided into 64 pieces, each of which is formed to a small tablet, containing approx 15mg ketamine 2) A double-blind test using Ketamine Chocolate tablets and placebo chocolate tablets in CRPS patients 3) A clinical comparative study between Ketamine Chocolate tablet and small dose im ketamine, in 33 pain patients with PHN, HZ or cancer pain
Results
-------
1) The taste ofKetamine Chocolate tablets is acceptable They are administered orally with no prbolem 2) Ketamme Chocolate tablets were found effective to relieve pain in 12/13cases, whereas the placebo tablets were in 5/12 (p<0 01)3) Sub-lingual ketamine Chocolate tablets decreased VAS from 43 4± 19 1 to 20 8± 14 1 (p<0 01), and 5mg ofim ketamine decreased from 42 9± 15 8 to 170±14 1(p<001) No significant difference was found between both
Conclusions Our Ketamine Chocolate tablet has high patient's compliance and yet powerful pain relief as much as that of 5mg of ketamine mtra-muscular administration They shall be beneficial to many patients who suffer from intolerable pain such as of CRPS, PHN, HZ and cancer.
