Kul69 Bluelighter Joined Nov 11, 2003 Messages 2,675 Jul 28, 2006 #1 Anyone know of an easy way to chlorinate methiazole?
Kul69 Bluelighter Joined Nov 11, 2003 Messages 2,675 Jul 28, 2006 #2 Using HCl seems to be the best idea but I wish I could find someone who has taken this beyond an idea and actually done it. Looks like I'm going to have to.. *gasp* experiment.
Using HCl seems to be the best idea but I wish I could find someone who has taken this beyond an idea and actually done it. Looks like I'm going to have to.. *gasp* experiment.
Smyth Bluelighter Joined Nov 10, 2004 Messages 2,157 Location England Jul 28, 2006 #3 Yeah consult vogel. You need anhydrous ZnCl2 and conc HCl under reflux. Also reduction of the ester group in WIN 35,065-2 followed by chlorination of the alcohol is a neat idea.
Yeah consult vogel. You need anhydrous ZnCl2 and conc HCl under reflux. Also reduction of the ester group in WIN 35,065-2 followed by chlorination of the alcohol is a neat idea.
