certain brands of generics being "weak"

[tsion]

Mallinckrodt hydrocodone pills, esp. the M361's are weak as hell and tend to make me more nauseated. Watsons are the best generic hydros I've had. One thing I've noticed, and this might only be me, but hydros or oxys with less tylenol give me less of a buzz. Watson's Lortabs (10/500) seem weaker than the Lorcet (10/650) The same for Percocet 10/650 vs Percocet 10/325. Whenever I come across OxyContin, I actually take some tylenol with them. Does anyone else experience that? I really think the tylenol (acetaminophen, APAP, whatever you want to call it) is synergistic with the opiate in the pill. So, to me, Watson 540's (Lortab) are weaker than Watson 503 (Lorcet).

I don't mean to be an asshole, but this is almost certainly in your head. I've been reading about this for about a decade now and every time someone I respect has chimed in on the topic, it's been repeated that APAP has no effect on the opiate.

 

[liquidheaven]

I always prefered the Norco's to the blue Lorcets.

 

[eieio]

tsion: so you have these 10/325 watsons.......and u've had the norco 10/325? which is better in your opinion? is it even that much of a difference? this is intriging.....i take norco's, but if there's something better out there, you better believe I'd like to have it. thanks for the help!

 

[eieio]

I might not have this straight after re-reading......is there a watson 10/325 AND a norco 10/325? or are the norco's watsons?

 

[axl blaze]

this would explain why on the streets buyers go for brand names more than generics.

 

[ChemicalSmiles]

I dont think the government would allow more than 5% of a difference... but if your taking 10 pills at a time and each one is 5% weaker I guess it would make a difference. It safe to assumeimo that peoples tolerances on this board are higher than the average person.

-weez

 

[tsion]

I might not have this straight after re-reading......is there a watson 10/325 AND a norco 10/325? or are the norco's watsons?

If memory serves, "Norco" is a non-generic brand, and the name is often used to describe all 10/325s. I usually hear Waston or Mallinkrodt 10/325's referred to as
"generic Norcos."

The front of my prescription bottle says "WATSON Hydrococone 10/325, Generic for Norco"

 

[tsion]

i've heard this back in the day from old timer's who dabble in pills. I guess according to them, generics are able to vary up to 15% in potency.

i don't remember the exact percentage it may be 5%, or something similar. Its been so long since i've fucked with these pharms.

I personally haven't noticed any difference in my methadose name brands and the generic's. Infact, sometimes i think i prefer generic methadone's.

That's odd! I've frequently heard Methadone users rant angrily about the weakness of "Methadose" brand....

 

[blahblahblah]

Ive noticed also in different brands of liquid methadone syrups

 

[LIVE4EVER]

I don't mean to be an asshole, but this is almost certainly in your head. I've been reading about this for about a decade now and every time someone I respect has chimed in on the topic, it's been repeated that APAP has no effect on the opiate.

Thanks for your response (and no, you're not being an asshole!
). I have a friend who believes the same thing. She will take extra tylenol, too. I guess placebo is a strange thing.

 

[dabluelitedude]

I don't mean to be an asshole, but this is almost certainly in your head. I've been reading about this for about a decade now and every time someone I respect has chimed in on the topic, it's been repeated that APAP has no effect on the opiate.

i doubt that 150 of apap is making a difference in your high

 

[fastandbulbous]

If you take pills that contain the same amount of active drug from 2 or more different manufacturers and grind them to a powder, then swallow them, there shouldn't be any difference because you've taken the tablet disintergration rate out of the equation.

From checking the regulations w.r.t. UK pharmaceutical drugs, they're allowed no more than a couple of percent variation in the dose (basically what could occur with the variation in purity of the active drug within the bounds of the assay as laid out in the British Pharmacopea)

 

[krippler]

i spoke to a pharmacist yesterday who is a friend of mine and a generic company only has to put 3% more or less of the active ingredient in the pill. my favorite generic are endo being the best, then ethex, then roxanne, and mallinkroft and mylan being on the bottom. i m switching pharmacies cause this one only has i think their mallinkrofts. i get the 4mg dilaudids and their white.

the ethex are a light brown with a redish tint and they are the best generic hydromorphone besides roxanne. endo i dont think makes a dilaudid. but as for your thread some generic companies suck. i cant find name brand dilaudids nowhere where im at in florida. i want the knolls. but i cant find them anywhere.

if someone knows of a pharm in fl that stocks them please pm me.

 

[krippler]

That's odd! I've frequently heard Methadone users rant angrily about the weakness of "Methadose" brand....

this is true. im on methadose as well and the name brand orange ones made by lilly are way stronger. i heard of a generic company named cybert that makes an orange methadone 40mg dikette with a laxative in it and they are stronger than the methadose im getting.

i guess its like getting wal marts frosted flakes or getting tony the tigers, ya know? i know methadone is stronger than methadose.

 

[krippler]

I dont think the government would allow more than 5% of a difference... but if your taking 10 pills at a time and each one is 5% weaker I guess it would make a difference. It safe to assumeimo that peoples tolerances on this board are higher than the average person.

-weez

my neighbor is a pharmacist and it used to be 5%, now its 3% more or less. now what company would put 3% more is what i wanna know.

 

[krippler]

some types of binders could not just slow absorption, but could decrease it also! there really should be some kind of database out there where people can compare brands of various medications in terms of potency and user reviews before they have to make medication choices. that would be EXTREMELY useful....

i agree 100%. if anyone finds this please please pm me or email me.

 

[geetered]

I cant imagine just a simple switch of binders could account for the obvious strength difference between perdue and teva oxys. They seriously feel 1/4 - 1/2 as strong. Is it simple binder changes or does it metabolize differently for some reason

I agree... the teva's fucking suck... but when there $20 cheaper that the real OC 80's there good

 

[fastandbulbous]

some types of binders could not just slow absorption, but could decrease it also! there really should be some kind of database out there where people can compare brands of various medications in terms of potency and user reviews before they have to make medication choices. that would be EXTREMELY useful....

Not unless they use things like activated charcoal as binders (they don't). All of the other usual binders & fillers (magnesium stearate, starch, lactose etc) do not inhibit absorbtion from the GI tract, so in terms of the dose of drug absorbed 10mg active compound of one generic is the same as any other that contains 10mg (within the 2-3% tolerance range, but that's 0.25mg difference max for a 10mg tablet). The reason there isn't any such table is because they are all of the same potency.

this is true. im on methadose as well and the name brand orange ones made by lilly are way stronger. i heard of a generic company named cybert that makes an orange methadone 40mg dikette with a laxative in it and they are stronger than the methadose im getting.

40mg of methadone from one company's tablets are not stronger than any others - you'll get 40mg into your system, regardless of the tablet manufacturer. Any perceived difference in strength is all in your mind - it it weren't, then there'd be no point in quality control etc as carried out by government regulators. It means that the same dose from two different makes of tablets would be different enough for one brand to cause an OD and the other one wouldn't - and that's patently incorrect.

If the dose you receive is 40mg, then it's 40mg regardless of the manufacturer. Any discussion that one brand is stronger is bollocks unless one of them is a counterfiet (and no reputable pharmacy should be dispensing those).

 

[OpiatesRus]

I dont think the government would allow more than 5% of a difference... but if your taking 10 pills at a time and each one is 5% weaker I guess it would make a difference. It safe to assumeimo that peoples tolerances on this board are higher than the average person.

-weez

You are def. right about that. Most people here are some serious opiate addicts. And i love it b/c i'm right there with them.

Peace People and have a great day I'm super morphined out right now%)

 

[krippler]

Not unless they use things like activated charcoal as binders (they don't). All of the other usual binders & fillers (magnesium stearate, starch, lactose etc) do not inhibit absorbtion from the GI tract, so in terms of the dose of drug absorbed 10mg active compound of one generic is the same as any other that contains 10mg (within the 2-3% tolerance range, but that's 0.25mg difference max for a 10mg tablet). The reason there isn't any such table is because they are all of the same potency.



40mg of methadone from one company's tablets are not stronger than any others - you'll get 40mg into your system, regardless of the tablet manufacturer. Any perceived difference in strength is all in your mind - it it weren't, then there'd be no point in quality control etc as carried out by government regulators. It means that the same dose from two different makes of tablets would be different enough for one brand to cause an OD and the other one wouldn't - and that's patently incorrect.



If the dose you receive is 40mg, then it's 40mg regardless of the manufacturer. Any discussion that one brand is stronger is bollocks unless one of them is a counterfiet (and no reputable pharmacy should be dispensing those).

cool. thanx for the info. so name brands arent better than generics?