Cendifensine (NOE-115) {SNDRI in clinical trials}

[Smyth2]

Did a patent search yesterday on SNDRIs and found the following:

[1] George GARIBALDI, WO2023161533 (to Noema Pharma AG).
[2] Jean-Michel Adam, et al. WO2013160273 (to F Hoffmann La Roche AG).
[3] Pravin Iyer, et al. WO2008074703 (to Roche Palo Alto LLC).
[4] Lucas, M. C., Weikert, R. J., Carter, D. S., Cai, H.-Y., Greenhouse, R., Iyer, P. S., Lin, C. J., Lee, E. K., Madera, A. M., Moore, A., Ozboya, K., Schoenfeld, R. C., Steiner, S., Zhai, Y., Lynch, S. M. (September 2010). "Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain". Bioorganic & Medicinal Chemistry Letters. 20 (18): 5559–5566. doi:10.1016/j.bmcl.2010.07.020.

I checked the website

Noema Pharma

OUR PIPELINE A Singular Focus on CNS Mediated Conditions Noema Pharma is committed to developing treatments for debilitating disorders of the central nervou ...

noemapharma.com

It could be that the compound is NOE-115 but it is still too early to say.
On this webpage it says NOE-115 "The therapeutic candidate is a triple reuptake inhibitor targeting, sodium dependent dopamine transporter, sodium dependent noradrenaline transporter and sodium dependent serotonin transporter. It is administered through oral route as a capsule."

 

[4DQSAR]

The compound was first prepared many years ago but I believe it was analgesic activity that it was screened for.

 

[Smyth2]

I just learned that NOE-115 has the nonproprietary name of Cendifensine.

 

[4DQSAR]

Well, the concept of treating depression and pain makes sense, but I have mentioned that if you produce a medicine that has two entirely different activities, practicioners cannot titrate to the dose of antidepressant and analgesic seperately.

Also the history of antidepressants is chequred to say the least.

 

[Rectify]

Not A Winner.

 

[Smyth2]

Aren't you optimistic about a novel SNDRI agent to reach the market?

I bought 10g of tesofensine from alibaba once and it was such garbage I thought i'd been scammed.

 

[4DQSAR]

No even slightly - read the history.