dimensiontripping
Bluelighter
This was written ages ago but it showed reproductive damage to sperm in test subjects that were exposed to cathinones in their diet derived from the khat plant.
http://www.ncbi.nlm.nih.gov/pubmed/2315943
"Abstract
(-)-Cathinone is the major psychoactive component of khat plant (Catha edulis Forssk.). Khat has been shown to produce reproductive toxicity in human beings and experimental animals. However, the chemical constituents of khat leaves responsible for sexual dysfunction are not known. In the present study cathinone enantiomers have been investigated for their reproductive toxicity in rats. Cathinone produced a dose-dependent decrease in food consumption and suppressed the gain in body weight. There was a significant decrease in sperm count and motility and increase in the number of abnormal sperms in cathinone treated animals. Histopathological examination of testes revealed degeneration of interstitial tissue, cellular infiltration and atrophy of Sertoli and Leydig's cells in cathinone treated animals. Cathinone also produced a significant decrease in plasma testosterone levels of the rats. Although both enantiomers of cathinone produced deleterious effects on male reproductive system, (-)-cathinone was found to be more toxic. From this study it may be concluded that the cathinone content in khat may be partially or totally responsible for the reproductive toxicity in khat chewers."
Now, I have a friend who recently tried 4-MMC once in the 400-500mg range intranasally and then 5 days later did 2 100mg doses plugged over the course of 2 hours with 80-100mg intranasally, totalling 350-400mg. He has become acutely aware of how toxic this chemical feels in his body. Even after years of experimental drug use with mdma, amphetamines and psychedelic RC's included, nothing has compared to what seems to be lingering side-effects. I have been looking for more officially documented studies on cathinone and cathinone related drugs. He originally thought once a week would be ok, but even after just 2 uses, sees that this should not occur very often and questions if redosing is actually the very dangerous part.
weird chest/burning pains with slight shaking after 2 days since the last use.
http://www.ncbi.nlm.nih.gov/pubmed/2315943
"Abstract
(-)-Cathinone is the major psychoactive component of khat plant (Catha edulis Forssk.). Khat has been shown to produce reproductive toxicity in human beings and experimental animals. However, the chemical constituents of khat leaves responsible for sexual dysfunction are not known. In the present study cathinone enantiomers have been investigated for their reproductive toxicity in rats. Cathinone produced a dose-dependent decrease in food consumption and suppressed the gain in body weight. There was a significant decrease in sperm count and motility and increase in the number of abnormal sperms in cathinone treated animals. Histopathological examination of testes revealed degeneration of interstitial tissue, cellular infiltration and atrophy of Sertoli and Leydig's cells in cathinone treated animals. Cathinone also produced a significant decrease in plasma testosterone levels of the rats. Although both enantiomers of cathinone produced deleterious effects on male reproductive system, (-)-cathinone was found to be more toxic. From this study it may be concluded that the cathinone content in khat may be partially or totally responsible for the reproductive toxicity in khat chewers."
Now, I have a friend who recently tried 4-MMC once in the 400-500mg range intranasally and then 5 days later did 2 100mg doses plugged over the course of 2 hours with 80-100mg intranasally, totalling 350-400mg. He has become acutely aware of how toxic this chemical feels in his body. Even after years of experimental drug use with mdma, amphetamines and psychedelic RC's included, nothing has compared to what seems to be lingering side-effects. I have been looking for more officially documented studies on cathinone and cathinone related drugs. He originally thought once a week would be ok, but even after just 2 uses, sees that this should not occur very often and questions if redosing is actually the very dangerous part.
weird chest/burning pains with slight shaking after 2 days since the last use.
