Cardiovascular effects of amphetamine in comparison to MDMA?

[wooger]

So I was wondering, which if these drugs causes the most notable increase in heart rate and blood pressure during the effects? and which is more likely to cause significant long term damage?

I have no basis at all for this but I always just thought it was amphetamine..maybe cus it just feels so much more ruthless on the body but I could be wrong. Could someone please help me out with this.

Thanks

 

[stirfry]

I think it's difficult to directly compare as the doses and pattern of use are so different with the two.

My gut feeling is that a recreational dose of MDMA (i.e. 100+ mg) probably has stronger cardiovascular side effects than say, 30mg of Adderall, in the short term. I think people tend to not notice the stimulant side effects on ecstasy because they feel too good to notice, whereas the hyper vigilant state induced by amphetamines makes people dwell on the cardiovascular load they experience.

But, it's important to note than people tend to only sporadically use MDMA, but amphetamine is commonly used on a daily basis (frequently at the urging of a doctor none the less). I think it's the compulsive nature of amphetamine use that makes it more likely to cause negative long term health effects.

But, this is all just speculation on my part, so take it with a grain of sand.

 

[kokaino]

I tend to believe that amphetamines are more taxing on the cardiovascular system than MDMA is. The problem with MDMA though, is neurotoxicity in long term use. A lot of amphetamines don't have this problem. Methamphetamine is neurotoxic (moreso than MDMA, even) is one of the exceptions.

Overall, amphetamines are worse for your health, especially methamphetamine. The end result of long term amphetamine abuse is insanity. MDMA doesn't have the same addiction potential, so use of MDMA is not as common as use of amphetamines among addicts.

 

[Cambo]

Tbh my heart rate doesn't increase THAT much with MDMA, don't get me wrong it increases quite a bit but was faster I think with Mephedrone.
Never tried Speed etc, so I couldn't actually compare.

 

[Psychedelic Jay]

I tend to believe that amphetamines are more taxing on the cardiovascular system than MDMA is. The problem with MDMA though, is neurotoxicity in long term use. A lot of amphetamines don't have this problem. Methamphetamine is neurotoxic (moreso than MDMA, even) is one of the exceptions.

Overall, amphetamines are worse for your health, especially methamphetamine. The end result of long term amphetamine abuse is insanity. MDMA doesn't have the same addiction potential, so use of MDMA is not as common as use of amphetamines among addicts.

This.

All amphetamines are neurotoxic. Especially when abused. The more potent amphetamines, the ones with more more adrenal responses, are going to be the ones with more significant heart load increases.

 

[Crankinit]

Methamphetamine is neurotoxic (moreso than MDMA, even) is one of the exceptions.

I'm fairly sure methamphetamine is less neurotoxic, on a per dose basis. The reason you see more meth users presenting with neurotoxicity is because it's more addictive and more inclined towards patterns of heavy binging.