Carbamenazapine and codeine.

[Jabberwocky]

Evening all,

So - I have been asking this for a while but never really get an answer, I was wondering if someone could help me out here.

I have carbamenzapine tablets and I've heard they are inducers of the enzyme needed to produce morphine in the liver from codeine. This would make the effect more profound if I'm not mistaken.

However the side effects from the drug are meant to be pretty horrific.

Has anyone had experience with mixing these? Say I took 50-100mg of carb. With the codeine ?

Thank you all.

 

[pasha]

Never heard of a drug called carbamenazapine, if your by any chance referring to carbamazepine or its anything similar it's extremely dysphoric by itself and with opioids.

 

[Jabberwocky]

That's the one.

Even in low doses its dysphoric?

 

[pasha]

Yah, I tried it with codeine and tramadol, there's nothing fun about it. Don't quote me on this but I think it blocks dopamine. Give it a try if your hell bent on it but I didn't like a thing about it, even at the 50 milligram doses.

 

[paranoid android]

I have taken carbamazepine in the past and i found it to be a very unpleasant drug. I was given it to try and help the pain of trigeminal neuralgia but the side effects such as vomiting, migraine intensity headaches as well as a weird dizzy feeling where so bad that i had to stop taking it. Plus it did not seem to help.

Carbamazepine it no drug to fuck around with as you need blood monitoring to check for things like toxicity or a drop in white blood cells as that can be a rare but life threatening adverse reaction. I have been on divalproex (Epival, Depakote, etc) and i found carbamazepine to be much rougher then that. It screws up the metabolism of many drugs as it is a CYP3A4 enzyme inducer. But codeine is metabolized into morphine by cyp2d6 so it won't speed up the conversion of codeine to morphine at all.

There are much safer drug you can use to make codeine feel stronger such as anti-histamines like doxylamine or promethazine as 2 examples that actually would work.

 

[N0 W4RN1NG]

^Beat me to it. Carbamazepine induces the enzyme CYP3A4, which will actually turn codeine into the inactive drug, norcodeine, not morphine.

Doxylamine sucks with opioids though, diphenhydramine or cyclizine are much better and both OTC. If you do take the codeine with carbamazepine, because you're prescribed carbamazepine and it's the kind of drug you should take every day, I recommend you drink white grapefruit juice with it to help prevent a loss of codeine into norcodeine.

 

[paranoid android]

^Beat me to it. Carbamazepine induces the enzyme CYP3A4, which will actually turn codeine into the inactive drug, norcodeine, not morphine.

Doxylamine sucks with opioids though, diphenhydramine or cyclizine are much better and both OTC. If you do take the codeine with carbamazepine, because you're prescribed carbamazepine and it's the kind of drug you should take every day, I recommend you drink white grapefruit juice with it to help prevent a loss of codeine into norcodeine.

I actually find doxylamine to be great at potentiating all opiates and so do alot of friends of mine actually. Not as good as hydroxyzine but still good. I wish we got cyclizine up here because it is supposed to be a really great anti-histamine to mix with opiates. Ive heard the methadone+cyclizine combo is supposed to pack a punch and i know alot of UK adicts used that combo to replicate the high from Diconal which is Dipipanone mixed with cyclizine in one pill.

 

[N0 W4RN1NG]

^ Indeed, cyclizine is a very good one, I had only discovered recently it was OTC here. It's sold as an off-brand formula "Bonine for kids" exclusively, which makes little sense to me but I suppose in low doses it might have reduced side effects in children. Hydroxyzine is great too, being a derivative of cyclyzine, but it's Rx-only in most places.

Ok man, different stroked for different folks - I always disliked doxylamine because it seems to make me so damn tired for the first hour, and then I feel like it's not even there anymore, but if you enjoy it then don't let me stop you!

 

[paranoid android]

^ Indeed, cyclizine is a very good one, I had only discovered recently it was OTC here. It's sold as an off-brand formula "Bonine for kids" exclusively, which makes little sense to me but I suppose in low doses it might have reduced side effects in children. Hydroxyzine is great too, being a derivative of cyclyzine, but it's Rx-only in most places.

Ok man, different stroked for different folks - I always disliked doxylamine because it seems to make me so damn tired for the first hour, and then I feel like it's not even there anymore, but if you enjoy it then don't let me stop you!

Oh damn it's OTC in the US? Holy shit . For some stupid fucking reason it's not on the Canadian market at all. Promethazine is OTC in Canada but no goddamn pharmacy stocks it at all! It's not just my province either as Ive tried to get it in another one as well. How fucking stupid is that?

Doxylamine is pretty drowsy but i find it to have less of the anti-cholinergic side effects that diphenhydramine has. Hydroxyzine is my favorite one for potentiating opiates of all sorts. Interestingly enough unlike most first generation anti-histamines hydroxyzine has very minimal anticholinergic effects. The sedation comes from it's very potent H1 antagonism. I find it to have some anti-anxiety properties on it's own actually and unlike diphenhydramine and other strong anticholinergic drugs it does not cause any of the restless leg syndrome or general body restlessness that some people like me get from it. So it's a much better all around drug then diphenhydramine in my opinion atleast. But i will have to stick to the doxylamine until i can get a script for hydroxyzine.