Cannabis chemical keeps mice slim

LogicSoDeveloped

LogicSoDeveloped

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A natural cannabis-like chemical in the brain may hold the key to keeping couch potatoes slim, early research suggests.
Scientists in the US found that blocking the compound allowed mice to gorge on high fat food and take little exercise without putting on weight or becoming unhealthy.

The genetically modified animals produced limited amounts of the endocannabinoid 2-AG, a chemical related to the active ingredient in cannabis.
All mammalian brains, including those of humans, contain 2-AG, which is believed to control neural circuits involved in metabolism.
"We discovered that these mice were resistant to obesity because they burned fat calories much more efficiently than normal mice do," said study leader Professor Daniele Piomelli, from the University of California at Irvine.

"We had known that endocannabinoids play a critical role in cell energy regulation, but this is the first time we found a target where this occurs."
The mice stayed slim because they developed a hyperactive form of "brown fat" - a special type of fat that generates heat and keeps animals warm.
Not only did they not gain weight when fed a high-fat diet, but they failed to develop any of the expected signs of metabolic syndrome. This is a combination of problems such as obesity and high blood pressure which increase the risk of heart disease and diabetes.
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source: http://www.google.com/hostednews/uk...51qr-BCxHz9nVp76A?docId=N0939711331042168550A


I always wondered why I lost weight when I started heavily smoking cannabis and then gained weight when I had to quit.
 
That actually makes so much sense to why I can just eat so much food and hardly be healthy but still be relitavley ok. Haha, thats great awesome find dude
 
Uh, it says blocking endocannabinoids prevents weight gain, I guess for the similar reasons rimonabant causes weight loss by blocking the CB1 receptor. THC should have the opposite effect. Unless it (THC) binds to CB1 but lacks some particular signalling component that 2-AG has?
 
When I was a daily smoker/user I went from 150-160lbs to 125-30lbs. I could (and did) eat whatever I wanted and could not put on weight. Never did any other drugs except the occasional low dose of xanax.
 
ive been off cannabis totally for 2 and a half months and haven't noticed any weight gain as yet. My appetite is still just as huge. I hope i do gain weight tho, im skinny as! Fast metabolism tho.
 
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