I did 2 hits of acid, then 30 mins after the acid comeup dropped a pill of mdma, and then a second about 2 hours or so after. It is interesting, though I have to say I would take an equal or lesser dose of acid than mdma as the acid (if you don't know this already) is a pretty strong psych. I found that the effects of mdma weren't as 'in your face' as they are when you just drop e by itself. I found that I had to search around a bit for the mdma effects, though the second pill was a bit more apparent. It is a very nice mixture, and I know a personal favorite for ALOT of people. Definitely a good party/raving combo, though don't expect the heavy empathy of the mdma that you may normally expect. I say take one hit of acid, wait for the come-up and maybe an hour or hour and a half later take the e, as I found I didn't get the full effect of combining the two when I was at the initial part of my acid trip.