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  • BDD Moderators: Keif’ Richards

Can you deplete the Gaba in your brain?

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I have abused alcohol and Gaba drugs and ambien drugs for a while. Right now I am constantly dizzy after dosing klonopin/xanax and ambien/beer last night. But I also recently came off my anti deppresent and it may have been too quick. I did celexa for 3 months and steppeddown over a week and half. Anyone with any incite it would be gravely appreciated!

YES YES YES ! I was on celexa for 9 months, 40mg , and i stopped cold-turkey. You are supposed to ween yourself off.

Google the effects of SSRI discontinuation syndrome, and you will find many people get "vertigo/dizzy/brain-zaps" from discontinuing (ssri's) too abruptly.

I definitely had STRANGE feelings for about three weeks once i quit celexa.

The reason why it takes so long for the withdrawals to stop is because of the incredibly high half lifes of these SSRI drugs.

The half life of celexa is 35 hours... longer than methadone...



BUT !


You are taking QUITE a bit of downers .

The dizzyness you are experiencing is probably exasperated by these GABAergic drugs. And the alcohol (not only effects GABA, but 5-HT, and dopamine as well.)

Now, taking an anti-depressant that is supposed to boost serotonin, in combination with taking a drug that effects serotonin don't seem to be like such good ideas :/.
 
Jay I have to disagree and Im not here to argue with you, however, calling me misinformed here is far from accurate. Not to mention I am not saying that this accounts for everyone either.

Your saying that mixing uppers and downersw have no effect on your heart rate? Well I'm referring to the yo-yo effect, which is where you play the drugs against each other.. Take the stims to stay up and party, then take the downers to come down off the stim and visa versa, that is how these are most commonly mixed and how I was refering to them, when taken together at the same time the drug whos foot print in the bodies chemistry plus the variable of the person themselves will govern how the heart rate goes. It is a proven fact that Stims tend to create increased blood flow which induces high blood pressure and usually in accompanied by and increased heart rate, and on the flip side, downers tend to lower the blood pressure and unless in WD tend to lower the heart rate. These are not things I made up, this is how the drugs work, this is what we are taught as medics to help understand whats going on with a person of whom we know they have ingested something but don't know what. I have been a medic for alomst 20 years, so you can't tell me that for 20 years they have been training medics wrong with the effects that the drugs have on the body. So the only thing I was really wrong here is saying is that it plays a game on your heart rate, well games are fun and this is no fun!

You are also assuming that all people who do drugs of any type are in perfect health and should know better then to take meds / drugs when they have underlying conditions. There my friend is where we differ greatly. 90% of the people who are abusing drugs of any sort, are generally NOT healthy people. They are not your track stars and if they were, I would worry more, but thats a story for another day. Your assumptions that people are perfectly healthy who do these things is just unrealistic. I have rarely met a "perfectly healthy" addict as you are saying they are.

Again, Im not going to battle back and forth with you on this, but the facts are the facts, look it up in any medical literature of the effects of these meds on the body. And again, Im talking about the yo-yo effect and not just taking a mouthfull of both together as noone can predict how the body will react from that. But taken at different time and at high enough doses to where you feel an effect from the drug most definitely have the effects I mentioned for the most part, keep in mind that there are exceptions to every rule, and Im sorry to say but them being healthy is not one I usually add to the equation, not in almost 20 years up picking up people who are practically dead from their party.

I will agree with one of your statements however..

It is well known that anyone with circulatory diseases should not do most if any recreational drugs...

ABSOLUTELY it is well known that they shouldn't... Now you need to tell the addicts / users that because generally they really don't care as long as they get their high.

If its any consolation, I reread how I originally type that jay and it does seem I was suggesting that having both drugs in the body together cause an interal confusion of like a rapid give and take, but that wasnt how it was meant. I should have stated that the mix meaning taking the stims, then later taking the downers or visa vera over a "period of time" can cause this problem. By no means did I mean that while you were on both the drugs would be vollying for control, which is how I believe you read that to be. My apologies there. Sorry for that confusion.
 
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There is no proof of any "yo-yo" effect.

Of course the effects of the drugs are going to effect heart rate. But your brain is perfectly capable of keeping it in check if you don't overdose on one or the other.

Using two drugs with around the same duration of effect is easier to manage.

There is no proof of this yo yo concept and tons of myths.

Your heart isn't going to flip out on recreational doses. You will have trouble if you overdose on one or the other. <<< This is what leads to the heart failure.

I am in no way referring to addicts. Just plain-jane recreational users.

Of course if you're are a addict, 9 out of 10 you are somewhat malnourished. Of course some people are going to have health problems. This is accounted for in me saying "...if you are a healthy individual..."

I didn't say your heart rate wasn't going to go up or down. I said your heart rate isn't going to speed up and slow down wildly. (Yo-Yo)

We don't want to scare the fun out of people... Ya know?

If you have high or low blood pressure, don't do it. If you have any circulatory issues, don't do it. If you are sick, don't do it.

That's the truth.
 
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Again, Im not saying it is going to flip out wildly, I am refering too, and please read again what I am saying, when you switch between the two there can be and is a "yo-yo" effect, its not myth nor am I making it up, and to be honest if people are scared of what is said here then so beit... ITS A HARM REDUCTION SITE!. And I am not saying that this will occurr with EVERYONE, but it can and DOES happen to people all the time. You can not deny the fact that it doesn't happen because its this very thing that I am refering too that kills the most innocent of "recreational" users. And the person to whom this whole thread was started over is not just the occasional recreational users. You have to keep this in perspective to the person who posted and people who abuse drugs recreationally or not. If your concerned about scaring people then your in the wrong place. This forum is about doing things safely and mixing drug no matter how innocent you want it to be is just not safe. Call it what you like yo-yo effect or what ever. When you switch between drugs that are meant to have opposite reactions will and can cause the body to respond in opposite ways.

Seriously Jay, you seem more about defending the practice of using drugs the way they were not meant to be used and you are missing the bigger picture of this entire thread. People should think twice before they start mixing their meds, the effects I'm referring too are very very REAL and while they may not occur to everyone, they DO occur. I am not here to sit and condone anyone's usage nor am I here to tell them they can't. Personally if you want to get fucked up, then you will, but you should know that there can, have, and will be consequences for doing these things and they happen to people all the time. I'm calling it a yo-yo effect, you call it what you want, but the facts are the facts, you cycle between stims and downers, your body is going to change its state based on the meds your taking. There is no point in argueing the fact and to be honest, I don't want to sit and argue over semantics either. The effects are real, the dangers are real. If someone is scared by this then they shouldnt be doing it in the first place and if I am wrong by making sure people are informed that what they are doing on a site dedicated to harm reduction can potentially kill them, then I think we are all on the wrong site. Because last I knew, this site was dedicated to letting people know the dangers and the safer ways of doing things even if it is using and abusing their meds recreationaly or not.

To be honest at this, the only thing we are doing is airing our differences on how we feel about the subject and we are railroading the topic of the original poster. There doesn't need to be anymore discussion regarding this point. It's not my post but honestly I think we should set our differences aside, give the thread back to the person who started it and let it lie the way it is. Neither one of us is wrong here accept your view of worrying about "scaring people". Everything I have stated is backed up in fact and is taught to medics to identify people in a drug crisis. Peace...

And last point, you don't need to OD to have heart failure from recreational use of drugs / meds. It happens to weekend worrior college students all the time who are perfectly healthy by all other means.
 
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