Can Stomach Contents Determine How Long Before A Pill Takes Effect ?

[RoxisLover]

I take 30mgs of roxi every morning and normally feel it take effect within 30 minutes and last a few hours. I have been constipated for about a week now and I know that I need a cleansing but I was wondering if this has any effect ? Because the past 2 days I took my pills as usual but didn't feel them. Then about a few hrs later it seemed to feel like they were just kicking in. Is this all in my mind or can this actually happen ?

 

[grrr8Dane]

Stomach contents can absolutely influence rate of absorption. When taking opiates orally, I've found it best to take them on an empty stomach and to take sodium bicarbonate about 15 minutes prior to taking the opiates. An alkaline stomach helps opiates that are ingested orally to be absorbed a bit quicker, thus the reason for using sodium bicarbonate.

It's also possible that stomach contents have nothing to do with what you are experiencing. You may simply be developing a tolerance.

 

[1114]

I've found sodium bicarbonate also helps with dextroamphetamine absorption, so maybe having a relatively alkali stomach is a rule of thumb for ingestion?

I think it's intuitive that empty stomach equates to a more intense high.

 

[grrr8Dane]

^^I honestly don't know if an alkaline stomach is a rule of thumb for everything ingested orally, but as far as orally ingested opiates are concerned, most definitely. I've noticed the same thing with orally ingested amphetamines too, and I can say for sure that sodium bicarbonate causes some benzos, Diazepam for example, to be absorbed and excreted slower.

 

[J. G. Wentworth]

dosing after a meal delays onset. Eating on an empty stomach helps get it into your system sooner. even something as simple as drinking a carbonated beverage like a diet coke helps push some of it through the linings of the stomach faster.

It seems to me, and I have nothing but my own experience tpo back this up, but if I need my pain pills to last longer, they do so on a full stomach, but it can take 90 minutes for it to fully hit my system. The delayed onset is probably why I think that.