• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Misc can memantine reverse methylphenidate tolerance?

Yes I am aware that D2's are auto receptors, what're you saying?

And niceeee if it's not too close to bedtime go ahead and try a bit :) If you ordered from PeakNootropics they hopefully gave you a little measuring scoop. Did I mention I thought you eyeballing noopept was hilarious lol? But seriously be careful <3
 
Yes they did , and yes lol it was . I had no clue that you were a girl, usually males are into neuroscience. Interesting haha.. it's 2:51 pm here bedtime is hours away.
 
Hahahaha I'm a guy, just a girly guy I guess lol, how much are you trying? People take various doses, I'd try a little less than a gram for starters you can always take more.

Some people do get insomnia if they take it within 10 hours of bedtime, I think it's half life is 6-7 hours
 
Rofl girly guy , haha at least you love supporting people, keep it up :). Anyways, I took piracetam 5 minutes ago, and the instructions suggest 2 1 level cc scoops (2 grams) right now is 5:00 pm , I hope I will able to sleep lol. So are the effects basically stimulation and increase in visual acuity? I've also heard that the effects of piracetam builds over time. I am going to actually start the concerta tolerance break with exercise/cardio, piracetam and noopept over the summer break as I have college now. But I took piracetam today and I'll take tomorrow to get a feel for it.
 
Oh shit you might be in for a long night lol... Yeah it's stimulating but it will kind of clear your thoughts typically, and many people report "HD" vision at the start but that effect tends to diminish for some. Lemme know if you feel anything a couple hours in. But I have heard people like to let the effects build up too and sometimes only feel them a couple days in rarely. Piracetam tends to be fairly weak and sometimes needs a bit higher doses, people with tolerance often take a couple grams.
 
It doesn't make much sense taking a drug with probably more side effectd than methylphenidate in attempt to reverse a short lived tolerance that will fade by itself in a matter of weeks. methylphenidate doesn't cause neurotoxicity or long term tolerance like the amphetamines do.

Most people taking ritalin for years experience little to no tolerance. If you feel like you have noticed some though, take a week off and it should go back down.
 
I don't really notice much , I am just awake right now, I don't go to bed until 9 or 10. The thing is through out the day I had food. Since piracetam is water soluble, the effects won't be as pronounced as it should be, such as taking it on an empty stomach. So I'll see how the rest of this night goes lol, and tomorrow. But I'll make sure to take this before food. In addition to that, this coming summer when I take the break and do whatever was advised , now with the exercising/cardio aspect I am very interested in taking d-aspartic acid and dhea for improving testosterone production and muscle mass, I love experimenting and taking supplements to help with gains, the question is, will taking d-aspartic acid hinder any progress with removing tolerance and aiding any ltp. How about dhea? It helps producing adrenaline , will it hurt or help? I've heard people getting an adrenal fatigue with dhea , does it mean dhea is antagonizing adrenaline receptors? Let me know thanks :)
 
I would avoid DHEA, there has been no evidence for its usefulness in several good trials - it has shown no increase in testosterone or lean muscle mass. But aspartic acid is fine, not sure if it does much either but it won't hurt you, it's something you normally get through your diet anyways. You will see much more benefits from whey protein with branch chain amino acids if you're working out.

Yeah I'm curious if you'll notice anything with higher dosages on an empty stomach with the piracetam.. That's kinda strange..
 
Okay , tomorrow upon ingesting piracetam , how long should I wait before taking food?
 
It's 8:42 pm (est) just in case you are wondering, We'll see how the rest of my night goes.
 
Cotcha Yankinov said:
Slight caveat and explanation for why there might be synergy between cycling a DRI and DRA - Some dopamine reuptake transporter inhibitors (such as cocaine and bupropion) up regulate the DAT, this means that you could expect increased strength of amphetamines within the short period that DAT remains up regulated because there will be more transporters available to reverse. But those two I mentioned happen to be a dopamine releasing agent / DAT inverse agonist so the up regulation of DAT is probably a compensation for increased dopamine in the synapse. But ultimately this has nothing to do with actual tolerance because the receptors will still be downregulated with high dopamine transporter concentrations, you'll just get more bang for your buck in terms of dopamine release specifically if using a mechanism that utilizes reversal of the transporter - most importantly, "sensitivity" is still decreased and you could get more overall dopamine activity with up regulated receptors and non up regulated DAT rather than upregulated DAT and down regulated receptors.
Click to expand...


Tolerance is decreasing because NDRA propel reuptake of monoamines, while NDRI inhibit it. Tolerance is decreasing because NDRA propel reuptake of monoamines, while NDRI inhibit it. These are reverse mechanisms.
 
You should know that receptors are useing ion channels (especially sodium), so ions are utilizing. On stimulants we need much more minerals. Without sodium you won't fell anything. Without calcium you will fell only fucked stimulation.
Stimulants in first phase of their work throw minerals into the brain but in second block absorption minerals to the brain.
Additionally, they cause hypoglycemia. Hypoglycemia cause loss of sodium. Further, sodium deficits cause other deficits. Even if you eat sodium, you pee it.
I would have started eliminate hypoglycemia and mineral deficits and after that reverse tolerance. Because, methylphenidate may not work as it should during mineral and energy deficits.

http://download.springer.com/static...ceb0d1e1ec01a4b3e70689a48d2a5722b3374b96b955a

Low-carb, high-fat diet and cinnamon for the cure of hypoglycemia.
Supplementing minerals by drinking water with salt with reduced sodium (because it contain potassium) and poppy seeds (because it contain every other mineral except sodium).

~​





http://nutritiondata.self.com/facts/spices-and-herbs/203/2
 
Last edited:
So cotcha , I took piracetam 2 hours ago , the dosage was 2 grams. I guess visually , things are brighter? , maybe a little stimulation I guess. Is too early to tell , I took concerta with it just for experimentation. I didn't really feel the effects potentiate really . I know I am going to have to take a a month break and exercise , piracetam, noopept are going to to be done daily, for ltp and tolerance reduction/removal. But it's still to early to tell , what I am experiencing from piracetam. I took it 45 minutes before break fast. Then after 45 minutes I ingested 2 raw eggs (choline source) am I supposed to take eggs right away or wait after 45 minutes because piracetam is water soluble. And Bobby , so before I start the regime advised by cotcha for ltp and tolerance , you pointed out that it's vital to have sodium (I have himalyan salt ) potassium (bananas) and calcium (milk, vitamin d) thanks, I will also take this into consideration. Now for this summer when I start with the break , my calories are going to consist of high carbs , adequate amount of protein and low fat. I found this to be most helpful for hgh release and protein synthesis. It is also recommended for those who want to add size but barely any fat. So is this fine? Cotcha , sounds like a plan?
 
Inform about the progress necessarily. I am curious.


Milk isn't good source of calcium. Metabolism calcium from milk does not allow to use by us. Milk is for suckling. Not for adult. Eat 2 tablespoon poppy seeds twice daily after meal and add 1 teaspoon of ginger. Ginger increase absorption everything. Pour into a 0,5 liter bottle one teaspoon this salt and sip all day.
If you want to supplement GDA of potassium from bananas you must eat about 4 kilograms.

When you on stimulant you use much more energy, so you must eat more. High carb diet is good but you would have to eat for every three hours.
Protein intake should be at least 1g/kg body mass. Protein from animal sources. The other calories you eat from carbs.
 
Last edited:
Hmm I'm surprised you're not feeling much at 2 grams, a standard regimen is 1800mg 3 times a day though, piracetam is pretty weak all things considered. But I would keep at it and definitely try the noopept, you might see more benefit a couple months from now. Nootropics by definition aren't supposed to produce a high though, so there might not be much subjective difference. Aniracetam/Oxiracetam and other higher rated racetams will have more potent effects. Oxiracetam is supposed to be very strong.

Protein is very important, I really like whey proteins myself, they typically include amino acids like leucine that are important for muscle. You can take an electrolyte pill if you'd like. Make sure you get good sleep as well.
 
Hello Bobby , read above post, later on I mostly felt foggy headed and an increase in visual acuity
 
and bobby, I won't undertake this actual regimen til summer. So it will be a while
 
You must log in or register to reply here.
Top