manwithaplan
Bluelighter
Impramine has a lone half life and it has a major interaction so i dunno.. advice?
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BDD Moderators: Keif’ Richards
Can I take Methadone 15 hours after impramine?
- Thread starter manwithaplan
- Start date
jasonmp321
Bluelighter
This is from a popular website, saying Imipramine has a MAJOR interaction with Methadone.
Methadone may cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. High dosages of methadone alone have been associated with QT interval prolongation and torsade de pointes. In a retrospective study of 17 methadone-treated patients who developed torsade de pointes, the mean daily dose was approximately 400 mg (range 65 to 1000 mg) and the mean corrected QT (QTc) interval on presentation was 615 msec. The daily methadone dose correlated positively with the QTc interval. Fourteen patients had at least one predisposing risk factor for arrhythmia (hypokalemia, hypomagnesemia, concomitant use of a medication known to prolong the QT interval or inhibit the metabolism of methadone, and structural heart disease), but these were not predictive of QTc interval. It is not known if any of the patients had congenital long QT syndrome.
Imipramine has a half-life of 11 - 25 hours, which mean's you should wait at least 48 hours before taking any Methadone.
Do not take any methadone for at least 48 hours after you've taken Imipramine or you may die
Hope this answers your question.
Methadone may cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. High dosages of methadone alone have been associated with QT interval prolongation and torsade de pointes. In a retrospective study of 17 methadone-treated patients who developed torsade de pointes, the mean daily dose was approximately 400 mg (range 65 to 1000 mg) and the mean corrected QT (QTc) interval on presentation was 615 msec. The daily methadone dose correlated positively with the QTc interval. Fourteen patients had at least one predisposing risk factor for arrhythmia (hypokalemia, hypomagnesemia, concomitant use of a medication known to prolong the QT interval or inhibit the metabolism of methadone, and structural heart disease), but these were not predictive of QTc interval. It is not known if any of the patients had congenital long QT syndrome.
Imipramine has a half-life of 11 - 25 hours, which mean's you should wait at least 48 hours before taking any Methadone.
Do not take any methadone for at least 48 hours after you've taken Imipramine or you may die
Hope this answers your question.