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Heroin Can GABAPENTIN reset/fuck with heroin detox?

Nether Animal

Nether Animal

Bluelighter
Joined
Sep 5, 2015
Messages
193
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Where the dead rule the night
I need to give you guys a timeline so there is some background here, I'll try and keep it punctual:

I've basically been forced by circumstance to kick heroin, been off/on user for 7 years, I know the drill and this was a 4 month bender:

Let's go back six days to last Wednesday which was the day after I ran out of options to use:

Wednesday: Used gaba (nothing else) to get through the day 1-3 grams daily average
Thursday: Used gaba again
Friday: Copped a little bit of dope, maybe used $20 worth throughout the day and ended up wasting the rest (my water bottle leaked on the table and ruined the bit I had saved)
Saturday: Cold turkeyed it
Sunday: Cold turkey again, but I'm maybe 6/10, its manageable with some weed
Monday: Got more gaba, used about 1.5 grams throughout the day spaced out, last dose was around 5pm. Went to bed at 11 and woke up at 2:45 drenched in sweat and feeling super dopesick, like I totally regressed to a week earlier, it was awful. I took 900mg gaba and it slowly went away.

Now it's been nearly twelve hours since then and I haven't taken anything else, and I feel (relatively) fine. What is going on here? It was far too pronounced to be PAWS, plus I've only used once in the last week. It was definitely dopesickness. I know PAWS can be up and down day to day, but this was like I totally regressed to the worst of the detox period, and the day before I was clean and able to function. This has never happened to me before.
 
Dysregulation of your GABA B receptors (don't argue: it does affect the GABA B receptors - just because one study says it doesn't, doesn't mean it does not; one study says it does affect it, and all my GABA books don't deny its activity but merely state that it is a matter of debate) and your calcium channels - specifically the N type calcium channel - from such high dosage of the gabapentin consistently could be the cause. Also the Kir channels that gabapentin binds to.

These are all major channels of activity in your brain, and a reduction in activity in any of them - not to mention all of them - could lead to kindling and excitation - and a worsening of any withdrawal syndrome.
 
Are those related to how opiate withdrawal works? I know they play a role somewhere but I though the opiate receptors rebounding was what causes jonesing.

I'm trying to be careful and not throw my head out of whack using these, which is why I didn't take any before going to sleep.
 
Mu opioid receptors are linked to inward rectifying potassium channels just like the GABA B receptor. The Kir channel is an inward rectifying potassium channe as welll. So you have reduced activity at all three. And the mu opioid receptor works by inhibiting GABA. So upregulation of your mu receptors is inhibiting GABA release. And you have reduced GABAergic activity because of downregulation of your GABA B receptors.
 
I'm on the fence. I'll know for sure after I wake up tomorrow morning and assess my condition. All of today I felt 7/10, pretty much like I should after not using for 4 days and once in the last week. So it definitely didn't "Reset" my withdrawal or anything.
 
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many many people are prescribed grams of gabapentin daily for years, some while on/off opiates for periods of time, and never experience anything like this. what makes you so confident that it was the gaba? truly curious.
 
In my experience using small amounts of opiates 3 days into a detox will cause more WD the next day but many times the WD will take longer to kick in. So if you went 3 days again and then relapsed on a small amount it may take even longer for the WD to kick in. For some gaba can cause inter dose WD's which may exacerbate your detox. Try spacing out the gaba more taking it 3x/day when you use the medication.
 
In my experience, Gabapentinoids, specifically Pregabalin (Lyrica) and Gabapentin (Neurontin) don't share any kind of cross-tolerance with Opioids, which is part of what makes them a useful adjunct for Opioid withdrawal.
 
Keif' Richards said:
In my experience, Gabapentinoids, specifically Pregabalin (Lyrica) and Gabapentin (Neurontin) don't share any kind of cross-tolerance with Opioids, which is part of what makes them a useful adjunct for Opioid withdrawal.
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Exactly. I don't want to needlessly drag it out. I took around 1.2g today spaced out /w 300mg doses. Worked very well, and while I was feeling the high come it almost feels like adderall at first, and sometimes it feels like a nasty crack hit (you get kinda anxious and paranoid almost) and it rotates between those two. This was the impression I got at least.
 
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