Caltech Chemists Devise Chemical Reaction that Holds Promise for New Drug Development

Gaius

Gaius

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"Making carbon-carbon bonds is hard, but that's what we need to make the complicated structures we're after," Stoltz says. "We're taking that up another notch by making carbon-carbon bonds in really challenging scenarios. We're making carbon centers that have four other carbon groups around them, and that's very hard to do."

The vast majority of pharmaceuticals being made today do not include such congested carbon centers, Stoltz says—not so much because they would not be effective compounds, but because they have been so difficult to make. "But now," he says, "we've made it very easy to make those very hindered centers, even in compounds that contain nitrogen. And that should give pharmaceutical companies new possibilities that they previously couldn't consider."
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Full article.

Most intredasting.
 
Good find. I see a Nobel prize in their future. I guess this means no more enantiomer knock offs like Nexium/Prilosec (a very good thing in my opinion).
 
panic_the_digital said:
I guess this means no more enantiomer knock offs like Nexium/Prilosec (a very good thing in my opinion).
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How does this entail that? It's still going to be profitable to begin with the racemic version and progress to the enantiomer once the patent runs out. The technology to make Nexium existed when Prilosec was approved.

edit: never mind. I missed this sentence:

For this reason, the FDA has increasingly required that the molecules in a particular drug be present in just one form.
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Meh, the only difference I see from a pretty standard chem paper is that they used a robot to screen for optimum conditions for that particular reaction.
 
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