I've read about an interesting combo. Appearently they're extremely synergetic.
California rocket fuel (SNRI plus mirtazapine) is a combination that has a great degree of theoretical synergy, norepinephrine reuptake blockade plus aplha 2 blockade, serotonin reuptake plus 5HT2A and 5HT2C antagonism, and thus many 5HT actions plus norephinephrine actions.
Specifically, 5HT is quadruple-boosted (with reuptake blockade, alpha 2 antagonism, 5HT2A antagonism, and 5HT2C antagonism). Norepinephrine is quadruple-boosted (with reuptake blockade, aplha 2 antagonism, 5HT2A antagonism, and 5HT2C antagonism.) And there may even be a double boost of dopamine (with 5HT2A and 5HT2C antagonism.)
Now currently I'm taking Wellbutrin and remeron, I don't want to mess with my SERTs too much, so I'm avoiding SSRIs, due to my past MDMA (ab)use.
Remeron has some memory improving properties, and wellbutrin seems very goosfor motivation and focus. My goal is to obviously be happy, but also not impair my cognitive performance, which SSRIs tend to do. I also want to avoid emotional bluntness.
So comment on this CRF even though I highly doubt I'll start it, but "if" I did how do you think this would affect cognition/memory etc.. It sounds like this could cause some nasty downregulation long term as well?
California rocket fuel (SNRI plus mirtazapine) is a combination that has a great degree of theoretical synergy, norepinephrine reuptake blockade plus aplha 2 blockade, serotonin reuptake plus 5HT2A and 5HT2C antagonism, and thus many 5HT actions plus norephinephrine actions.
Specifically, 5HT is quadruple-boosted (with reuptake blockade, alpha 2 antagonism, 5HT2A antagonism, and 5HT2C antagonism). Norepinephrine is quadruple-boosted (with reuptake blockade, aplha 2 antagonism, 5HT2A antagonism, and 5HT2C antagonism.) And there may even be a double boost of dopamine (with 5HT2A and 5HT2C antagonism.)
Now currently I'm taking Wellbutrin and remeron, I don't want to mess with my SERTs too much, so I'm avoiding SSRIs, due to my past MDMA (ab)use.
Remeron has some memory improving properties, and wellbutrin seems very goosfor motivation and focus. My goal is to obviously be happy, but also not impair my cognitive performance, which SSRIs tend to do. I also want to avoid emotional bluntness.
So comment on this CRF even though I highly doubt I'll start it, but "if" I did how do you think this would affect cognition/memory etc.. It sounds like this could cause some nasty downregulation long term as well?