caffeine tolerance and 2cs

[gib65]

I've noticed a couple times that after taking 2c-c, my tolerance to caffeine goes way up. This makes sense since both are stimulants and probably work on similar receptors in the brain. But what I want to know, and hopeful others with experience can shed some light on this, is whether it works the other way around - that is, does becoming tolerant to caffeine affect the potency of 2c-c (or any other 2c)? In other words, if I want to trip on a 2c this weekend, would it be best to abstain from caffeine until then?


I try to abstain from caffeine generally and so the last two times trying 2c-c weren't good tests of this, but I will give myself caffeine days (usually Friday). But if I plan to trip on a 2c on Saturday, would my tolerance be shot by consuming caffeine on Friday?

 

[Mjäll]

I would think the main action of a 2C-x isn't its slight stimulating effect but rather its psychedelic serotonergic agonism. But I'll be happily corrected if so :D

 

[mr.mackey]

the 2C-X's primary mechanism of action is serotonergic while caffeine seems to be as an Adenosine antagonist, so I think cross tolerance may be more psychological than pharmacological if that makes sense.

So, No, I do not think that there should be any cross tolerance

 

[TheAzo]

The day after i trip, i'm always a bit out of it and tired, and caffine doesnt change that.

I don't think this is a case of tolerance, just of another condition (psych hangover, if you can call it that) preventing you from getting the desired effects from the caffeine.

I've noticed no effect on the trips from how much caffeine i'd been consuming in the days leading up to the trip, and my coffee consumption varies widely week to week.

 

[alantis360]

yeah i just think caffiene is not nearly strong enough no matter how much to wake you up like normal after tripping, your body and mind are tired.

 

[gib65]

Thanks for the info.