By what exact mechanism do anticholinergics cause delirium?

[WeirdCrazyShortGuy]

I know how drugs like atropine, scopolomine, and diphenhydramine work. But what exact changes do they cause in the brain to cause one to experience delirium? I know they don't agonize serotonin receptors like lsd or mushrooms.

 

[Cane2theLeft]

They antagonize muscarinic acetylcholine receptors. For more information, look into anticholinergic toxidrome or muscarinic antagonists.

 

[madog11]

OD > ADD

Think you should get some better responses here.

 

[Epsilon Alpha]

There are several mechanisms off the top of my head including pretty much shutting down ACh transmission in the hippocampus (give you the memory of a goldfish), but I need to stop procrastinating now