Bupropion mixed with stims/opiates

[bios]

Hi everybody! Im cuorious what possible effect could have mixing some substances with dopamine-norepinephrine reuptake inhibitor antidepressant Wellbutrin (bupropion). I have made some research by myself but wasnt able to find answers to some points. Want to be sure about certain things to lower adverse and possible long term negative effects.

1. Mixing with stimulants with dopamine-norepinephrine releasing (not reuptake) properties. Recently I got my hands on a research chemical called Pentedrone (Penta) which seems to act simillary as MDPV - DNReleasing (which I personally found unpleseant, bit shaky, no euphoria). So my question is If wellbutrin is blocking these receptors and one cant get high because of that? (similliar as buprenorphine and opiates) Does mixing different DNRIs and releasing agents increase the risk of potential seizure?

-I have to point that I was able to get high while using bupropion before with cocaine (which is according to wikipedia reuptake ihibitor too) or meth.

2. I have previously mixed Tramadol and Codeine with no noticable side effects others that are common to opiates. Heroin and other opiates and opioids use CYP2D6 or CYP2B6 to metabolize, same as bupropion. Is there a big threat because of interaction on the same enzyme?

And my last question is whether is safer to not take regular morning wellbutrin 150mg dose If one is planing to do drugs during the day? ..Or It has no effect because half life is 20 hours. Thanks. (and sry for my english)

 

[Oxide]

Mixing bupropion with anything else that reduces the seizure threshold is a risky endeavor.

I may have a slight bias toward bupropion due to the the seizure I accidentally had after taking my prescribed 150mg dosage of Wellbutrin SR in the morning, and then taking 150mg tramadol later that day, though.

 

[Jabberwocky]

Is there a big threat because of interaction on the same enzyme?

with what two substances? codeine and tramadol or other opiates/oids combined with bupropion? either will be fine. i double checked with an online drug interaction checker between bupropion and a few opioids for interactions and there were none. codeine and tramadol don't have any life threatening interactions though there will be minimal competition at p450 between theml. tramadol is metabolised via cytochrome p450 (isozyme CYP2B6, CYP2D6 and CYP3A4) while it's thought only around 5% of codeine is metabolised by p450, the main active thought to be codeine-6-glucuronide (C6G).

And my last question is whether is safer to not take regular morning wellbutrin 150mg dose If one is planing to do drugs during the day

what drugs?

 

[bios]

Thanks for the answers. Ive seen warnings tramadol/bupropion because of both lowering seizure threshold. Also online drug interaction checker say so. I have combined before 150mg SR morning dose and 200mg tramadol which I find very euphoric, while aware of the risks. The other time 180mg of codeine which was not as nearly as pleasant experience (nausea, itching and pain in back of my head).

with what two substances?

I meant opiates in general and bupropion.

what drugs?

Research chemical stimulants acting on the same receptors as bupropion does. (MDPV or Pentedrone)

 

[Jabberwocky]

sorry, for some reason your second post was flagged by the spam shield which is why it didn't show up.

Research chemical stimulants acting on the same receptors as bupropion does. (MDPV or Pentedrone)

i can't accurately answer that but i agree with oxide here especially when you're dealing with RC's. i'd avoid combining them.

there's a few good MDPV threads throughout OD as well as EADD . use the search function in each of them and you'll find some good information.

 

[bios]

There are many threads about MDPV and stuff.. also interactions with SSRIs but nothing about NDRIs like WELLBUTRIN. I have to find out if it blocks the receptors and prevents the drug to enter. And what is the "safe" time from last bupropion dose to do dopamine-norepinephrine based drugs to get the full effect. Any info would be appreciated!

 

[Jabberwocky]

And what is the "safe" time from last bupropion dose to do dopamine-norepinephrine based drugs to get the full effect. Any info would be appreciated!

that depends. enough time for it to have fully cleared from your system. if you've been on it for a decent time frame you're going to have a steady state plasma-concentration levels built up which need to reach zero to effectively be safe.

the half-life of bupropion is around 21hrs and takes 8 days to reach peak blood-plasma levels.

 

[sekio]

The general rule of thumb is that the washout period for most a/ds is 2 weeks. As far as I know buproprion is not a super strong NDRI in the same wasy that pentedrone is, though the two will potentiate each other.

 

[bios]

Does pentedrone also release dopamine like meth? (there is very little info on this compound). MDPV from my experience is very harsh shitty drug (no euphoria, slight stimulation, cravings to do more). Does this mean that all NDRI stimulants are in fact the same and will have similliar effect on me as MDPV?