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Bupropion inhibiting metabolism of tramadol/opioid withdrawal

FungousSneeze

Bluelighter
Joined
Nov 24, 2017
Messages
61
Im currently in acute opioid withdrawal and only have access to 50mg ultram tabs.

I take daily 200mg bupropion, 50mg trazadone and lastly 3200mg gabapentin.

I am aware of the seizure risk with bupropion interacting with tramadol. Im also aware that bupropion inhibits a liver enzyme prevents tramadol from converting to its more potent metabolite.

My question is has anyone been to able to get any relief from tramadol while on bupropion. Im fairly confident that the dose of gabapentin im taking will negate any seizure activity at therapeutic doses of both medications. Just mainly concerned about the metabolism of both medications.

I have searched everywhere and have not found anyone describing an experience of taking both medications concurrently with efficacious relief from tramadol. Mostly just warnings of harm reduction about seizures. Both doses i will be taking will remain in the therapeutic range. Not recreational. Again currently in withdrawal seeking relief
 
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