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Bupropion Analogue

Ham-milton

Ham-milton

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Does anyone know if a chlorine-free version of bupropion has been tested?

Was it a decent stimulant? Have there been any other 3-halophenyl amphetamines or cathinones either on the market or lab tested?

I would imagine that without the 3-chloro, bupropion would probably make for a decent DARI, probably less prone to the depersonalization and feeling like shit that it causes (in my experience- started off a week of horrible panic attacks from just 1 dose, never touched it again).

Hammilton
 
Hear you on the Bupropion.At least it can cure the sexual side effects of SSRI's quite good.

In my view its less the chlorine which is the culprit here but rather the bulky t-Butyl group.One might have to make the 3-Chloro-methcathinon,but some are avoiding the halogens like the plague.It might be a valid point on the amps but the cathinons are Another class of compounds.Ah yeah in fact Bupropion is not neurotoxic!
 
Yeah, it's not always possible to take 'rules' for amps and apply them to cathinones, but I don't know that they're so different that inferences can't be drawn.

I'm sure the butyl group is going to put a limit on what you could do to improve bupropion without removing it, but the 3-chloro can't possibly do anything but make it less euphoric and lower the potency, no?

Are we sure it's not neurotoxic? Since it doesn't have much recreational potential, it's never gonna get the sort of high-dose stunts that you see with truly euphoric drugs, like MDMA or meth. It seems likely that the only reason we haven't seen neurotoxicity is because nobody enjoys it enough to go that far with it.
 
Ham-milton said:
Have there been any other 3-halophenyl amphetamines or cathinones either on the market or lab tested?
Click to expand...

fenfluramine = 3-trifluoromethyl-n-ethyl-amphetamine.
 
In the old PDR, it mentions using fenfluarmine at 80-400mg dosages and it causing euphoria, hallucinations, etc. I wish I had it in front of me. I've never taken the drug, but I thought some study showed it substituted for MDMA at some level.
 
I realize that, but given that the PDR actually mentioned that people would abuse the drug at 80-400mg dosages for "euphoria and hallucinations" may (or may not) be an indicator of something interesting beyond being a simple stimulant (or appetite suppressant without stimulant effects as it was touted.)
 
15-30mg dexfenfluoramine produced only mild stimulation with no hints of an interesting effect when dosed higher. tried it three times at this dose, administered orally and sublingually.
then again one might say the same when taking 50mg mdma for the first time.
a friend also took 30mg dexfenflouramin and was reminded of some really bad pills he had some months before. in fact he was so disappointed that he never touched dexfen again. hearing that from a tweaker that normally eats everything that might resemble mdma or meth lead me to the above conclusion.
 
well considring why it was withdrawn would not think it is the best avenue to explore though one can at least argue N-methyl-1-[3-(trifluoromethyl)-
phenyl]propan-2-amine would be legal in the US
 
Wow, my memory isn't as bad as I thought.

Here is from the PDR...

Abuse of 80 to 400 milligrams of the drug has been reported to be associated with euphoria, derealization, and perceptual changes. Fenfluramine did not produce signs of dependence in animals and appears to produce sedation more often than CNS stimulation at therapeutic doses.
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I don't know any other drug (not even sansert) that reads like this. Well, except for ketamine.

That doesn't sound like belladonna 'hallucinations' to me. I think there might be something there.
 
And the cleaner serotonin releasers/entactogens are more sedative than stimulative,with some people finding it not pleasant.400mg is somewhat more than 30mg or what was the highest dose you tried izo?

The 4-Trifluoro-methamphetamin will tell you the final story!And I bet it will be liked by many.
 
yes, 30mg was the highest dose i went for and it'll probably stay that way.
besides you'll find high dose reports on almost every clinically approved amphetamine based anorectic that state effects like euphoria and perceptual changes.
just an uneducated guess but one might get better (read more euphoric and safer) results with 3-F or 4-F amphetamines when it comes to entactogens.
 
hugo24 said:
Hear you on the Bupropion.At least it can cure the sexual side effects of SSRI's quite good.

In my view its less the chlorine which is the culprit here but rather the bulky t-Butyl group.One might have to make the 3-Chloro-methcathinon,but some are avoiding the halogens like the plague.It might be a valid point on the amps but the cathinons are Another class of compounds.Ah yeah in fact Bupropion is not neurotoxic!
Click to expand...


Art thou sure that bupropion is not neurotoxic? I would agree with avoiding halogens like the plague - they would seem to lend to neurotoxicity. The tert-butyl group might be the saving grace of the compound.
 
Ham-milton said:
Does anyone know if a chlorine-free version of bupropion has been tested?

Was it a decent stimulant? Have there been any other 3-halophenyl amphetamines or cathinones either on the market or lab tested?

I would imagine that without the 3-chloro, bupropion would probably make for a decent DARI, probably less prone to the depersonalization and feeling like shit that it causes (in my experience- started off a week of horrible panic attacks from just 1 dose, never touched it again).

Hammilton
Click to expand...

im not that educated in pharmacology, just curious on how halogenated compunds affect recpetor sites. does attaching a halogen usually lead to decreased activation or different side effects? (or do halogens usually have their own inherent qualities as how they affect the compound they are attached to, pharmacology wise?)
 
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thunderwolf said:
Art thou sure that bupropion is not neurotoxic? I would agree with avoiding halogens like the plague - they would seem to lend to neurotoxicity. The tert-butyl group might be the saving grace of the compound.
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It's the t-butyl group that does away with most of the CNS stimulatiom. As you increase the size of an alkyl* group on the amine nitrogen of amphetamine, the potency drops off drasticallyN-ethyl amph is about 60-70% the potency ofmethamphet; N-propyl is about 40-50% that of methamphet, but N-(n)butyl is about 10% and as you bulk up the group, it gets rapidly worse.

N-isopropyl is also a group that tends to inpart beta adrenergic activity (drugs like isoprenaline, salbutamol etc) that'll make your heart pound out of your chest. as well as being a sight less potent as a psychomotor stim than the straight chain, N-substituted group

On a final point, people don't seem to be considering 3-halo substitution is the same as 4-halo sub, which is a bit of an error. One of the metabolic routes for amphetamines is para-hydroxylation to make it more poar & therefore easirer to remove. Tis is blocked by a 4 fluoro, but what a 3-fluoro group does to it's metabolism just isn't the same (as would a 2-halo group as well) - it does seem to make it more toxic though (fenfluramine & pulmonary hypertension, bupropion & convulsions)


alkyl* - the benzyl of benzphetamine and related drugs is very easily cleaved from the amine group so they 'don't count' other than being an amphetamine prodrug
 
rave23 said:
i think halogens are all about the electronegativity
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i understand that the halogens are electronegative and all that jazz, but im curious as to how they affect the body and/or receptors differently when attached to an already active compound.

and hey fastandb! does adding the t-butyl group drop the potency because of sterics, or is there another factor involved?
 
Deseryl's (trazodone's) active metabolite is mCPP which stands for meta-chlorophenylpiperazine. So take some trazodone and extrapolate your subjective findings from the phenyl piperazine class of drugs to the amphetamine class of drugs.

That being said (and done) by me already, I am willing to venture that
3-chloro(meth)amphetamine is no less than fantastic.
 
and hey fastandb! does adding the t-butyl group drop the potency because of sterics, or is there another factor involved?
Click to expand...

It's all about bulk. It doesn't fit into the receptor well, thus more is needed.
 
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